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  • 1
    Electronic Resource
    Electronic Resource
    Abstracts of posters (1993)
    Springer
    Pharmacy world & science 15 (1993), S. H5 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872875
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  • 2
    Electronic Resource
    Electronic Resource
    The use of ultrasonography and Doppler in the prediction of fetal haemolytic anaemia: a multivariate analysis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess the value of ultrasonography and Doppler to predict the severity of fetal haemolytic anaemia.Design Ultrasonographic measurements of the fetal liver, spleen, umbilical vein and placenta, and Doppler measurements of umbilical venous and fetal aorta flow velocities were performed before the first intrauterine blood transfusion. Multivariate regression models for the prediction of the fetal haemoglobin level were derived from the measurements.Setting National referral centre for management of alloimmunised pregnancies.Subjects Forty fetuses in 39 severe red cell alloimmunised pregnancies.Results A logistic regression model, incorporating the two Doppler parameters only, predicted the presence or absence of severe anaemia in nonhydropic fetuses with an accuracy of 90 %. Positive predictive value was 89% and negative predictive value was 100%.Conclusion In severe red cell alloimmunised pregnancies, Doppler blood flow velocity studies can be used to predict the severity of fetal anaemia. This may lead to a reduction of invasive diagnostic tests, to more accurate timing of intrauterine transfusions, and thus to a higher survival rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13184.x
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  • 3
    Electronic Resource
    Electronic Resource
    Prenatal Diagnosis of Homozygous αº-Thalassemia by an Immunological Method (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 731 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb55769.x
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  • 4
    Electronic Resource
    Electronic Resource
    The contribution of DNA analysis to carrier detection and prenatal diagnosis of hemophilia A and B (1992)
    Springer
    Annals of hematology 64 (1992), S. 2-11 
    Details
    ISSN: 1432-0584
    Keywords: Hemophilia ; Genetic counseling ; Carrier detection ; Prenatal diagnosis ; DNA ; RFLP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Developments in DNA technology have provided a novel means of carrier detection and prenatal diagnosis of hemophilia A and B. The collection of a large set of data has enabled us to evaluate the present feasibility and reliability of a diagnosis at the gene level and its contribution to methods already available. Since 1984, 533 potential and obligate carriers belonging to 170 families with hemophilia have been referred to us. By the combined use of pedigree analysis, coagulation assays, and DNA (RFLP) analysis, certainty about the carrier status has been markedly increased for the potential carriers. Although RFLP analysis revealed the possible origin of the mutation in many families with an isolated patient, uncertainty remained for quite a number of their female relatives because of the possible occurrence of germline mosaicism. Forty-one women requested prenatal diagnosis during one or more pregnancies. The short time interval between pregnancies, even after abortion of an affected fetus, proved that first-trimester prenatal diagnosis has become an acceptable option for women at risk. Recently, efficient methods for direct identification of mutations have been developed, and they may allow a definite diagnosis for all families with hemophilia in the near future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01811464
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  • 5
    Electronic Resource
    Electronic Resource
    The extravascular contractile system in the human placenta (1994)
    Springer
    Anatomy and embryology 190 (1994), S. 541-548 
    Details
    ISSN: 1432-0568
    Keywords: Human placenta ; Smooth muscle-like cells ; Perivascular contractile sheath ; Nitric oxide synthase type I ; Dipeptidyl peptidase IV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the human placenta, besides the fetal blood vessel system a second extravascular contractile system exists. It is localized in the chorionic plate and runs in a longitudinal direction and adjacent to fetal blood vessels into the stem villi, where it forms perivascular contractile sheaths. Characteristically, cells of the extravascular contractile system are extremely long and spindle-shaped and give rise to fine cell processes, by which they obviously contact each other or insert into the basement membrane of the trophoblast. They show immunoreactivity with desmin, vimentin, α-actin, myosin, nitric oxide synthase type I (brain form) and dipeptidyl peptidase IV. The ultrastructure suggests that cells of the extravascular contractile system are related to smooth muscle cells, including subpopulations with myofibroblastic features. In stem villi a few cells are nitric oxide synthase type I immunoreactive. These cells are thought to be specialized smooth-muscle-like cells of the extravascular contractile system or cells of the extravascular contractile system related to paraneurons that generate nitric oxide, which, in turn, may modulate the tone of perivascular contractile sheaths. The high dipeptidyl peptidase IV activity suggests that modulation of the extravascular contractile system may also occur by substance P.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190104
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  • 6
    Electronic Resource
    Electronic Resource
    Separation, enrichment, and characterization of human hematopoietic progenitor cells from umbilical cord blood (1993)
    Springer
    Annals of hematology 67 (1993), S. 231-236 
    Details
    ISSN: 1432-0584
    Keywords: Human hematopoietic progenitor cells ; Umbilical cord blood ; Cell separations ; FACS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human umbilical cord blood (UCB) may be used as an alternative source of bone marrow repopulating cells in allogeneic bone marrow transplantation in children. It has been reported that high numbers of hematopoietic progenitor cells (HPC) from umbilical cord blood may be lost during simple cell-separation techniques. This may seriously hamper the use of UCB as an alternative source of bone marrow repopulating cells. In this study we demonstrate that UCB can be separated into various cell fractions using several cell-separation methods including red blood cell lysis, methylcellulose sedimentation, and density gradients without significant loss of HPC, when cell separations are initiated within 8 h. We demonstrate that UCB contains a high concentration of immature HPC as compared with bone marrow grafts. Using FACS analysis of cells harvested from single colonies derived from single cell- single well-sorted CD34++ CD33− UCB cells, the high frequency of multipotential HPC was illustrated. These results suggest that UCB may contain sufficient HPC for hematopoietic stem cell transplantation in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715053
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  • 7
    Electronic Resource
    Electronic Resource
    Anti-inflammatory pharmacology and mechanism of the orally active capsaicin analogs, NE-19550 and NE-28345 (1990)
    Springer
    Inflammation research 31 (1990), S. 329-340 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have evaluated the properties of a new class of anti-inflammatory agents derived from capsaicin, using the analogs NE-19550 (N-vanillyloleamide) and NE-28345 (N-oleyl-homovanillamide) as examples. This class displayed an atypical profile in the assays utilized, including 1) anti-edema and antileukocyte migration activity in the rat carrageenan pleurisy assay without suppression of pleural prostanoid synthesis, 2) blockade of human platelet aggregation induced by arachidonate or PAF but not that induced by the PGH2 analog U-46619, without equivalent inhibitionin vitro of mammalian cyclooxygenase or thromboxane synthetase preparations, 3) greater potency and efficacy in the rat implanted sponge assay than in the adjuvant arthritis assay, without inhibition of LTB4 or 15-HETE synthesisin vitro, 4) stronger topical activity in the mouse croton oil inflamed ear assay than the guinea pig UV erythema assay, and 5) oral activity in the rat carrageenan paw edema assay and mouse phenylquinone abdominal constriction rest combined with failure to induce gastric erosion in rats at therapeutic doses. We conclude that NE-19550 and NE-28345 do not act like conventional NSAIDs via suppression of arachidonic acid metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997628
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  • 8
    Electronic Resource
    Electronic Resource
    Collagenolytic activity in experimental intestinal anastomoses (1992)
    Springer
    International journal of colorectal disease 7 (1992), S. 95-101 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On pense que la dégradation du collagène joue un rôle important dans la séquence de cicatrisation des anastomoses intestinales, mais on ne connait presque rien des activités enzymatiques concernées. Nous avons étudié les activités collagénolytiques extraites d'anastomoses intestinales d'un jour chez le rat. Utilisant soit un collagène soluble type I ou fibrillaire Type I ou un collagène type III comme substrat. Les activités mesurées dans les extraits provenant des segments anastomotiques ont été comparées à celles des extraits provenant d'un intestin non traumatisé enlevé au cours d'une intervention: dans tous les cas l'activité collagénolytique des extraits anastomotiques est significativement plus élevée. Cette augmentation était significativement plus prononcée au niveau du colon que de l'intestin grèle. Les activités étaient considérablement inhibées par le serum ou par des composés métallo-chélateurs. Les analyses, au moyen d'une électrophorèse de gel SDS-polyacrylamide, des réactions produites par les extraits de la dégradation de collagène fibrillaire type I révélaient la présence d'une multitude de fragments, parmi lesquels des fragments TA caractéristiques d'une activité de collagénase de mammifère. Ainsi la capacité de dégradation envers divers substrats de collagène est renforcée dans la zone anastomotique durant la première pérìode postopératoire et une véritable collagénase de mammifère est un des enzymes présents.
    Notes: Abstract Collagen degradation is thought to be an integral part of the healing sequence of intestinal anastomoses, but almost nothing is known about the enzyme activities involved. We have studied collagenolytic activities, extracted from 1 day-old intestinal anastomoses in the rat. Using either soluble type I collagen or fibrillar type I or type III collagen as a substrate, activities measured in extracts from anastomotic segments were compared to those in extracts from uninjured intestine, removed at operation: in all cases, the collagenolytic activity in anastomotic extracts was significantly higher. This increase was significantly more pronounced in large bowel than in small bowel. The activities were strongly inhibited by serum and metallo-chelating compounds. Analysis, by means of SDS-polyacrylamide gel electrophoresis, of the reaction products of the degradation of fibrillar type I collagen by the extracts revealed the presence of a multitude of fragments, amongst them TcA fragments characteristic for the activity of mammalian collagenase. Thus, the degradative capacity towards various collagen substrates is enhanced in the anastomotic area during the first postoperative period and a true mammalian collagenase is one of the enzymes present.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341294
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  • 9
    Electronic Resource
    Electronic Resource
    Metabolites of the plasticizer di (2-ethylhexyl) phthalate in urine samples of workers in polyvinylchloride processing industries (1993)
    Springer
    International archives of occupational and environmental health 64 (1993), S. 549-554 
    Details
    ISSN: 1432-1246
    Keywords: Di(2-ethylhexyl) phthalate ; Polyvinylchloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Little is known about occupational exposure to the plasticizer di(2-ethylhexyl)phthalate (CAS number 117-81-7), a compound widely used in polyvinylchloride (PVC) plastics. We have studied the uptake of DEHP in workers by determining the concentrations of four metabolites of DEHP in urine samples, i.e., mono(2-ethylhexyl)phthalate (MEHP), mono (5-carboxy-2-ethylpentyl)phthalate, mono(2-ethyl-5-oxohexyl)phthalate, and mono(2-ethyl-5-hydroxyhexyl)phthalate. In addition DEHP concentrations in the air were determined by personal air sampling. Nine workers in a PVC boot factory exposed to a maximum of 1.2 mg/m3 DEHP showed an increase in the urinary concentrations of all four metabolites over the workshift. These results were obtained on both the first and the last day of the workweek. With the exception of MEHP, the increases in the concentrations of the metabolites during a workday were statistically significant. Six workers from a PVC cable factory exposed to a maximum of 1.2 mg/m3 DEHP showed a one-to fourfold increase in the concentrations of the four metabolites over the workshift, but these increases were not statistically significant. These results indicate that measurement of DEHP metabolites in urine samples may be of use for monitoring the occupational exposure to DEHP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517699
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  • 10
    Electronic Resource
    Electronic Resource
    Liquorpheresis (CSF-filtration): An effective treatment in acute and chronic severe autoimmune polyradiculoneuritis (Guillain-Barré syndrome) (1991)
    Springer
    European archives of psychiatry and clinical neuroscience 241 (1991), S. 73-76 
    Details
    ISSN: 1433-8491
    Keywords: Liquorpheresis ; CSF-pheresis ; CSF-filtration ; CSF-immunoadsorption ; Acute Guillain-Barré syndrome ; Chronic polyradiculoneuritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In recent years, plasmapheresis has become a well established treatment of acute and chronic polyradiculoneuritis (Guillain-Barré syndrome, GBS). Nervertheless, there are still non-responders and there are particular risks associated with this treatment. Despite all efforts, the duration of severe forms of Guillain-Barré syndrome is still considerable. Inflammation and demyelination start intrathecally. We therefore used liquorpheresis (cerebrospinal fluid filtration) as a new effective therapeutic approach. Our first patient, severely disabled with acute GBS, artificially ventilated, had undergone plasma exchange without effect. Plasma immunoadsorption led only to transient improvement. After several liquorphereses, the patient recovered completely. In three additional patients with acute and two with chronic GBS an improvement of clinical signs in close temporal relation to liquorpheresis was observed. Twice, liquorpheresis was combined with immunoadsorption of cerebrospinal fluid. Liquorpheresis was well tolerated in all cases. This procedure may be effective by eliminating humoral or cell-bound factors responsible for the onset or/and maintenance of inflammation. Further controlled studies are necessary and are in progress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02191143
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