ISSN:
1399-3038
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
To study the roles of eosinophils and catecholamines in the pathophysiology of exercise-induced asthma [EIA], an exercise challenge test was performed in 22 asthmatic children, using a bicycle ergometer, and the changes in lung function, plasma norepinephrine (NE), epinephrine (E) and eosinophil cationic protein (ECP) levels with exercise were evaluated. Subjects were classified into three groups from the results of lung function test, respectively: EIA-negative group. EIA-positivc groups with good recovery and poor recovery. Eosinophil counts before exercise in the EIA-positive groups were significantly higher than those in the EIA-negative group. The ECP levels rose with exercise in all groups. Five minutes after exercise, ECP values fell to the pre-cxercise level in the EIA-negative group, hut rose to higher levels in EIA-positive groups. Plasma E levels rose with exercise and showed 4-fold increase in the EIA-negative group, whereas only 1. 5-fold increase of plasma E levels was observed in the EIA-positive group with poor recovery. From these findings, a possible contribution of sympathoadrenal hypofunction and a probable involvement of eosinophils in the pathophysiology of EIA have been suggested.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1399-3038.1993.tb00096.x
Permalink
