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  • 1990-1994  (3)
  • 1
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Three new saponins, alatoside A-C (4a, 5, and 6a, resp.), with a 18,19-secours-12-ene skeleton were isolated from the aerial parts of Sesamum alatum THONN. (Pedaliaceae) by preparative liquid chromatography. Their structures were elucidated by spectroscopic methods, including X-ray diffraction analysis, and by chemical degradation (acidic and enzymatic hydrolyses). In addition, verbascoside (1) and two cyclohexylethanol derivatives, rengyol (2a) and isorengyol (3a), were isolated and identified.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two new phenylpentadienamides isolated from the culture filtrate of Streptomyces sp. were assigned the structures 5-(4-aminophenyl)penta-2,4-dienamide (2) and N2-[5-(4-aminophenyl)penta-2,4-dienoyl]-L-glutamine (3). In addition, 5-(4-aminophenyl)penta-2,4-dienoic acid (1) has been isolated, and its spectroscopic characteristics are reported for the first time. Compounds 1-3 exist in both the (2E,4E)- and (2E,4Z)-configurations. Electrospray and tandem MS, and HPLC/MS proved to be particularly suitable for the characterization of these metabolites.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0170-2041
    Keywords: Aborycin ; Peptides ; Antibiotics ; Streptomyces griseoflavus TÜ 4072 ; HIV ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The screening for growth inhibitors against Bacillus subtilis revealed a peptide antibiotic produced by Streptomyces griseoflavus TÜ 4072. Very high yields of the antibiotic named aborycin were obtained by cultivation in a medium containing soybean meal and sucrose. Isolation from the mycelium was carried out by a combination of extraction and gel chromatography. Preparative HPLC yielded the uniform antibiotic. The structure elucidation was based on GC amino acid analysis on a chiral phase, automated Edman degradation, electrospray tandem mass spectrometry and two-dimensional NMR (TOCSY, ROESY, HSQC, HMBC). Aborycin represents a 21-peptide that is cyclized from the side chain of Asp9 to the N-terminus of Cys1. Two disulfide bonds Cys1 to Cys13 and Cys7 to Cys19 form a tricyclic structure consisting exclusively of protein amino acids. The peptide antibiotic aborycin was found to be identical with a HIV protease inhibitor isolated recently from Streptomyces SP 9440.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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