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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 59 (1990), S. 435-442 
    ISSN: 1439-6327
    Keywords: Acute maximal exercise ; Chronic submaximal exercise ; Leucocyte populations ; Lymphocyte populations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Absolute (×103·mm−3) or relative (%) numbers of blood leucocyte types (monocytes, lymphocytes, neutrophils) and lymphocyte subsets (T11+, T4+, T8+, B1+, and NKH1+) reacting with specific monoclonal antibodies were determined at rest, immediately after maximal exercise on a treadmill, in six controls (C), and in six young cyclists before training (BT) and after 5 months of training (AT). Maximal exercise significantly increased the absolute number (mobilization) of virtually all the types of leucocytes and subsets of lymphocytes in C, BT and AT subjects. In these subjects mobilization of natural killer cells (NKH1+) and cytotoxic/suppressor T lymphocytes (T8+) was greater than mobilization of the other leucocyte types and lymphocyte subsets; however, maximal exercise induced no significant changes in the relative numbers of any leucocyte types and lymphocyte subsets, except in the case of T4+ lymphocytes in AT cyclists. Chronic submaximal exercise induced increased mobilization of neutrophils and decreased mobilization of lymphocytes during maximal exercise, except in the case of B lymphocytes (B1+) and NKH1+ cells, and decreases in the absolute and relative number of neutrophils at rest. It remains to be seen how these results can explain the modifications of leucocyte activities noted in vitro after isolated or chronic exercise.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 61 (1990), S. 223-229 
    ISSN: 1439-6327
    Keywords: Blood lactate ; Anaerobic threshold ; Previous supra-maximal exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twelve male and female subjects (eight trained, four untrained) exercised for 30 min on a treadmill at an intensity of maximal O2 consumption (% $$\dot V$$ O2max) 90.0%, SD 4.7 greater than the anaerobic threshold of 4 mmol ·1−1 (Than =83.6% $$\dot V$$ O2max, SD 8.9). Time-dependent changes in blood lactate concentration ([lab]) during exercise occurred in two phases: the oxygen uptake ( $$\dot V$$ O2) transient phase (from 0 to 4 min) and the $$\dot V$$ O2 steady-state phase (4–30 min). During the transient phase, [lab] increased markedly (l.30 mmol · l −1 · min −1, SD 0.13). During the steady-state phase, [lab] increased slightly (0.02 mmol · 1−1 · min−1, SD 0.06) and when individual values were considered, it was seen that there were no time-dependent increases in [lab] in half of the subjects. Following hyperlacticaemia (8.8 mmol -l−1, SD 2.0) induced by a previous 2 min of supramaximal exercise (120% $$\dot V$$ O2max), [lab] decreased during the $$\dot V$$ O2 transient (−0.118 mmol · 1−1 · min−1, SD 0.209) and steady-state (−0.088 mmol · 1−1 · min −1, SD 0.103) phases of 30 min exercise (91.4% $$\dot V$$ O2max, SD 4.8). In conclusion, it was not possible from the Than to determine the maximal [lab] steady state for each subject. In addition, lactate accumulated during previous supramaximal exercise was eliminated during the $$\dot V$$ O2 transient phase of exercise performed at an intensity above the Than. This effect is probably largely explained by the reduction in oxygen deficit during the transient phase. Under these conditions, the time-course of changes in [lab] during the $$\dot V$$ O2 steady state was also affected.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 62 (1991), S. 385-389 
    ISSN: 1439-6327
    Keywords: Energy cost of running ; Distance ; Fatigue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The net energy cost of running per unit of body mass and distance (Cr, ml O2·kg−1·km−1) was determined on ten amateur runners before and immediately after running 15, 32 or 42 km on an indoor track at a constant speed. The Cr was determined on a treadmill at the same speed and each run was performed twice. The average value of Cr, as determined before the runs, amounted to 174.9 ml O2·kg−1·km−1 SD 13.7. After 15 km, Cr was not significantly different, whereas it had increased significantly after 32 or 42 km, the increase ranging from 0.20 to 0.31 ml O2·kg−1·km−1 per km of distance (D). However, Cr before the runs decreased, albeit at a progressively smaller rate, with the number of trials (N), indicating an habituation effect (H) to treadmill running. The effects of D alone were determined assuming that Cr increased linearly with D, whereas H decreased exponentially with increasing N, i.e.C r =C r0+aD+He−bN. The Cro, the “true” energy cost of running in nonfatigued subjects accustomed to treadmill running, was assumed to be equal to the average value of Cr before the run for N equal to or greater than 7 (171.1 ml O2·kg−1·km−1, SD 12.7;n = 30). A multiple regression of Cr on N and D in the form of the above equation showed firstly that Cr increased with the D covered by 0.123%·km−1, SEM 0.006 (i.e. about 0.22 ml O2·kg−1·km−1 per km,P〈0.001); secondly, that in terms of energy consumption (obtained from oxygen consumption and the respiratory quotient), the increase of Cr with D was smaller, amounting on average to 0.08%·km−1 (0.0029 J·kg−1·m−1,P〈0.001) and thirdly that the effects of H amounted to about 16% of Cr0 for the first trial and became negligible after three to four trials.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 65 (1992), S. 464-468 
    ISSN: 1439-6327
    Keywords: Physical training ; Acute exercise ; Lymphocyte ; T-cell growth factor ; Thymus ; Stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was a detailed examination of the effects of moderate exercise on T-cells in adult male Wistar rats. The T-cell populations were compared in sedentary rats (C, n = 5) and in rats trained for 4 weeks on a treadmill (30–60 min·day−1, 6 days·week−1, 20–30 m·min−1) and sacrificed at rest (Trest, n=5). In the T-rest rats, there were higher percentages of CD4+CD8−, CD4− CD8 + and CD4 − CD8 −thymocytes (P〈0.05, P〈0.05 and P〈0.01 respectively) and of CD4−CD8 + splenocytes (P〈 0.01), and a lower percentage of CD4−CD8+ cells in the lymph nodes (P〈0.01). Compared with T-rest or C rats, trained rats (n = 5) or untrained rats (n = 5) sacrificed immediately after a running session (60 min, 30 m·min−1) had a higher percentage of mononucleated cells CD4 + CD8 -in the blood (P〈0.05 and P〈0.01). Lastly, compared with C rats, rats (n=5) sacrificed immediately after their 5th day of training (30–60 min·day−1) presented a higher total splenocyte population (P〈0.05) and greater in vitro production of T-cell growth factor (interleukin 2 + interleucin 4) by splenocytes in response to a mitogen (P〈0.01). These results would indicate that moderate endurance training modifies the cellular composition of lymphoid organs, without impairing the in vitro functions of T-cells.
    Type of Medium: Electronic Resource
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