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  • 1
    Electronic Resource
    Electronic Resource
    Structure of lantadene A, the major triterpenoid of Lantana camara, red variety (1991)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 47 (1991), S. 810-812 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270190008897
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  • 2
    Electronic Resource
    Electronic Resource
    Molecular structure of Lantadene-B&C, triterpenoids ofantana camara, red variety: Lantadene-B, 22β-angeloyloxy-3-oxoolean-12-en-28-oic acid; Lantadene-C, 22 β-(S)-2′-methyl butanoyloxy-3-oxoolean-12-en-28-oic acid (1993)
    Springer
    Journal of chemical crystallography 23 (1993), S. 469-472 
    Details
    ISSN: 1572-8854
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract (I)Lantadene-B: C35H52O5,M r =552.80, MonoclinicC2,a=25.65(1),b=6.819(9),c=18.75(1) Å,β=100.61(9),V=3223(5) Å3,Z=4,D x =1.14 g cm−3 CuKα (λ=1.5418A),μ=5.5 cm−1,F(000)=1208,R=0.118,wR=0.132 for 1527 observed reflections withF o ≥2σ(F o ). (II)Lantadene-C: C35H54O5·CH3OH,Mr=586.85, Monoclinic,P21,a=9.822(3),b=10.909(3),c=16.120(8)Å,β=99.82(4),V=1702(1)Å3,Z=2,D x =1.145 g cm−3, MoKα (λ=0.7107Å), μ=0.708 cm−1 F(000)=644,R=0.098, wR=0.094 for 1073 observed reflections. The rings A, B, C, D, and E aretrans, trans, trans, cis fused and are in chair, chair, sofa, half-chair, chair conformations, respectively, in both the structures. In the unit cell the molecules are stabilized by O-H⋯O hydrogen bonds in both the structures, however an additional C-H⋯O interaction is observed in the case of Lantadene-C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01182520
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  • 3
    Electronic Resource
    Electronic Resource
    The gonadotropin-releasing hormone (GnRH) agonist-induced initial rise of bioactive LH and testosterone can be blunted in a dose-dependent manner by GnRH antagonist in the non-human primate (1992)
    Springer
    Urological research 20 (1992), S. 317-321 
    Details
    ISSN: 1434-0879
    Keywords: GnRH agonist ; GnRH antagonist ; Luteinizing hormone ; Testosterone ; Monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gonadotropin-releasing hormone (GnRH) agonists induce a clinically undesirable, transitory but very pronounced initial rise of gonadotropin and gonadal steroid secretion. We investigated, in a non-human primate model, whether the initial stimulatory effects of GnRH agonists can be avoided by a short period of pretreatment and simultaneous treatment with a GnRH antagonist. Three groups of five adult male cynomolgus monkeys (Macaca fascicularis) received a single s.c. biodegradable implant loaded with the GnRH agonist, buserelin ([D-Ser(TBu)6-desGly-NH2]-GnRH), releasing approximately 50 μg buserelin daily. From 1 week before to 1 week after inception of administration of GnRH agonist, group 1 received the GnRH antagonist vehicle, and groups 2 and 3 were given s.c. injections of the GnRH antagonist Nal-Glu ([Ac-D-Nal(2)1,D-4-Cl-Phe2, D-Pal3, D-Arg5,D-Glu6(AA),D-Ala10]-GnRH) at a dose of 450 or 2250 μg/kg daily. In the absence of GnRH antagonist, the GnRH agonist induced a marked elevation of serum luteinizing hormone (LH) and testosterone lasting for 2 and 5 days, respectively. In group 2, Nal-Glu reduced basal hormone secretion and delayed the peak of GnRH-agonist-induced hormone secretion by 1 day. In group 3, the GnRH-agonist-induced rise of LH and testosterone was prevented in three animals and did not exceed baseline hormone levels in the other two animals. Areas under the LH and testosterone curves were significantly reduced in group 3 compared to group 1. After withdrawal of the GnRH antagonist, a second transient rise of hormone secretion was observed. Except for testosterone in group 2, this rise did not exceed the baseline range of hormone concentrations. The study demonstrates that high doses of GnRH antagonist can prevent the GnRH agonist-induced initial rise of LH and testosterone secretion, while after withdrawal of the GnRH antagonist a second rise of hormone secretion occurs, which is less pronounced than with GnRH agoniit alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00922743
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  • 4
    Electronic Resource
    Electronic Resource
    The enzymatic profile of urine and plasma in bovine urinary bladder cancer (enzootic bovine haematuria) (1991)
    Springer
    Veterinary research communications 15 (1991), S. 421-426 
    Details
    ISSN: 1573-7446
    Keywords: acid phosphatase ; bladder ; cancer ; cattle ; haematuria ; lactate dehydrogenase ; urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The enzymatic profile of urine and plasma in field cases of bovine bladder cancer was studied. Urinary lactate dehydrogenase activity was significantly altered along with the isoenzyme pattern. Activity of alkaline phosphatase and β-glucuronidase was decreased in the affected animals. No significant changes were observed in acid phosphatase, or arylsulphatase A and B activity. In plasma, lactate dehydrogenase activity was elevated without any change in the isoenzyme pattern. No significant changes were observed in the other plasma enzymes studied or in the sialic acid concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346537
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    Paper (German National Licenses)
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