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  • 1
    Electronic Resource
    Electronic Resource
    Pulsatile immunoreactive and bioactive luteinizing hormone secretion in adolescents with chronic renal failure (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 566-571 
    Details
    ISSN: 1432-198X
    Keywords: Puberty ; Dialysis ; Transplantation ; Chronic renal failure ; Hormones ; Bioassay ; Hypothalamo-pituitary axis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Delayed or arrested pubertal development is common in children with chronic renal failure (CRF). Normal puberty is initiated by the onset of episodic nocturnal secretion of luteinizing hormone (LH) containing an increasing proportion of bioactive hormone. To test the functional integrity of the hypothalamo-pituitary axis in CRF we measured immunoreactive (i-LH) and bioactive (bio-LH) plasma LH concentrations at 15-min intervals from 2000 to 0700 hours in 65 pubertal patients aged 10–23 years [46 boys/19 girls; 20 on conservative treatment (CT), 13 on dialysis (D), 32 with transplants (TP)]. i-LH was determined by radio-immunoassay and bio-LH by a mouse Leydig cell assay. Peak detection was performed by the cluster analysis computer programme. The mean (±SD) number of i-LH (in both sexes) and bio-LH pulses (in boys) per profile, and the mean peak area of i-LH (in both sexes) and bio-LH (in girls) were higher in TP than in CT or D patients. The ratio of bio-LH to i-LH increased during puberty in CT (G1 vs G4/5, 0.3±0.5 vs 1.8±0.,4) and TP (0.6±0.7 vs 1.8±0.7) but remained low in male D patients (0.4±0.7 vs 1.1±0.8). The ratios were subnormal, however, even in mature TP patients compared with healthy adults. The bio-LH/i-LH ratio and the bio-LH peak area best predicted integrated nocturnal testosterone concentrations in TP but not in uraemic male patients. The data demonstrate that in adolescents with CRF, secretion of LH is tonic rather than pulsatile and bioactivity of the hormone is reduced. Both phenomena may contribute to the delay of sexual maturation. In TP patients the pulsatile pattern of LH secretion is restored and bioactivity increases. Corticosteroid treatment may be responsible for the incomplete normalization of the bio-LH/i-LH ratio in CRF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01453703
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Body growth in urinary tract malformations (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 151-155 
    Details
    ISSN: 1432-198X
    Keywords: Body growth ; Urinary tract malformations ; Hydronephrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Body height and height velocity were analysed in 54 children with obstructive urinary tract malformations over a mean period of 8.7 years, using new auxological methods. At the time of diagnosis, 9% of patients had a height of more than 2 standard deviations below the normal mean. Mean relative height changed significantly from the first to the last observation, the standard deviation score (SDS) increasing from −0.16 to +0.36 in patients with hydronephrosis compared with normal children (P〈0.05) and from −0.63 to +0.02 SDS in those without hydronephrosis (P〈0.005). The pathogenesis of the described growth disturbance is not clear. Stepwise multiple regression analysis pointed to a possible link between the duration of antibiotic treatment and the recovery of growth capacity, but improved growth could not clearly be attributed to any medical or surgical treatment. The synchronized average growth velocity curve was similar to that of healthy children and showed a normal pubertal spurt. Final height and target height calculated from parents' height differed only slightly from that of the normal population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00864383
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of human immunodeficiency virus-1 (HIV-1) rev by (time-resolved) fluorescence spectroscopy (1994)
    Springer
    Journal of fluorescence 4 (1994), S. 299-302 
    Details
    ISSN: 1573-4994
    Keywords: Protein fluorescence ; distributional analysis ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Fluorescence spectroscopy has been applied to the single tryptophan-containing regulatory protein Rev of human immunodeficiency virus (HIV-1). The fluorescence emission was found to have a maximum at 336 nm which refers to a surrounding of the chromophore of intermediate polarity. Fluorescence transients recorded at the maximum of fluorescence were found to decay nonexponentially. A bimodal lifetime distribution is obtained from exponential series analysis (ESM) with centers at 1.7 and 4.5 ns. Two microenvironments for tryptophan are suggested to be responsible for the two lifetime distributions. No innerfilter effect occurred in a Rev solution up to a concentration of 40 μM. A data quality study of ESM analysis as function of collected counts in the peak channel maximum (CIM) showed that, for reliable reconvolution, at least 15,000 CIM are necessary. The widths of the two distributions are shown to be temperature dependent. The broadening of the lifetime distributions when the temperature is raised to 50°C is interpreted as extension of the number of conformational substates which do not interconvert on the fluorescence time scale. The thermal deactivation (temperature quenching) is reflected in a constant decrease in the center of the short-lived lifetime distribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01881444
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    Paper (German National Licenses)
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