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  • 1
    Electronic Resource
    Electronic Resource
    Canine distemper virus-immune complexes induce bystander degeneration of oligodendrocytes (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 402-407 
    Details
    ISSN: 1432-0533
    Keywords: Brain cell cultures ; Bystander demyelination ; Canine distemper virus ; Oligodendrocytes ; Immune complexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Demyelination in chronic canine distemper encephalitis may be the result of a bystander effect in which the antiviral immune response is involved. In the present report we demonstrate that canine distemper virus-antiviral antibody immune complexes induce oligodendroglial degeneration in mixed brain cell cultures, particularly at the level of the cell processes. The involvement of macrophages as effector cells in this process was confirmed by depletion of these cells from the cultures which prevented the immune complex-mediated oligodendroglial degeneration. Canine distemper virus-immune complex-induced oligodendroglial pathology is thought to be mediated by toxic factors released from stimulated macrophages. this bystander effect demonstrated here in vitro may be relevant to the mechanisms of demyelination in vivo, in which virus persistence plays an important role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713532
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Peripheral and central distal axonopathy of suspected inherited origin in Birman cats (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 143-146 
    Details
    ISSN: 1432-0533
    Keywords: Cat ; Distal axonopathy ; Dying-back neuropathy ; Heredodegeneration ; Neurological disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three female cats, littermates born from clinically normal parents, were examined at 8 to 10 weeks of age because of a slowly progressive posterior ataxia. Another cat from a previous litter from the same parents suffered from similar neurological symptoms. Histopathological examination of the nervous tissues of these animals revealed degeneration of axons and myelinopathy in a distal distribution pattern. Both peripheral nerves and central nervous system were involved. The central nervous system lesions were most prominent in the lateral pyramidal tracts of the spinal cord, the fasciculi gracili of the dorsal column in the cervical spinal cord and the cerebellar vermian white matter. In the PNS numerous degenerating nerve fibers were found in the sciatic nerves but not in the spinal nerve roots. Our findings show that these cats were suffering from a hereditary multisystem degeneration with a distribution pattern of the lesions suggestive of a distal axonopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293957
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural and biochemical findings in brain cell cultures infected with canine distemper virus (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 59-67 
    Details
    ISSN: 1432-0533
    Keywords: Brain cell culture ; Canine distemper virus ; Cerebroside sulfotransferase ; Electron microscopy ; Oligodendrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To study the pathomechanism of demyelination in canine distemper (CD), dog brain cell cultures were infected with virulent A75/17-CD virus (CDV) and examined ultrastructurally. Special attention was paid to the oligodendrocytes, which were specifically immunolabelled. In addition, cerebroside sulfotransferase (CST), an enzyme specific for oligodendrocyte activity was assayed during the course of the infection. Infection and maturation as well as CDV-induced changes were found in astrocytes and brain macrophages. Infection of oligodendrocytes was rarely seen, although CST activity of the culture markedly decreased and vacuolar degeneration of these cells occurred, resulting in their complete disappearance. We concluded that the degeneration of oligodendrocytes and demyelination is not due to direct virus-oligodendrocyte interaction, but due to CDV-induced events in other glial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294222
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Loss of virulence of canine distemper virus is associated with a structural change recognized by a monoclonal antibody (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 842-845 
    Details
    ISSN: 1420-9071
    Keywords: Avirulence ; canine distemper virus ; monoclonal antibody ; virulence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The monoclonal antibody (mAB) L1, which binds to the nucleocapsid protein of canine distemper virus (CDV), was shown to bind to avirulent CDV obtained after serial passages in Vero cells, but not to two different virulent demyelinating CDV-strains propagated in dog glial cell cultures. However, when both virulent CDV-strains were passaged through Vero cells they expressed, after a number of passages, an epitope recognized by mAB L1. The occurrence of the L1 epitope appeared to coincide with loss of virulence in animal inoculation experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922469
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    Paper (German National Licenses)
    Fulltext
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