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  • 1
    Electronic Resource
    Electronic Resource
    Idiotypic Replica of an Anti-Human Tumour-Associated Antigen Monoclonal Antibody DNA Sequence Comparison between Ab1 and Ab3 (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 34 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 2G-3 is an anti-anti-idiotypic MoAb (Ab3) obtained upon immunization wiih a monoclonal Ab2 (A3B10), which behaves as the “internal image” of CaMBrl. a saccharidic epitope defined by MoAb MBrl (Abl), CaMBrI is expressed on glycoconjugates of the human mammary carcinoma cell line MCF-7 und on normal and neoplastic mammary gland epithelial cells, Abl and Ab3. although exhibiting, in many respects, superimposable paratopic and idiotopic specificities, show a non-identical fine immunoreactivity, since 2G-3 has a preferential reactivity with the saccharidic epitope mounted on glycoproteins. while MBrl reacts with both glycoproteins and glycolipids, V-region sequence analysis has shown that: (i) the VK genes employed belong to different families(VK 1 and VK 10); (ii) the J K2 segment is shared by the two L chains(thus a high degree of homology is observed between VK CDR3s): (iii) the VH genes employed derive from the same family VHIIBJ55K (but show CDR homology only in CDR2): (iv) different JM region genes are employed. These data together with the comparison of deduced secondary structure parameters give further evidence fur the possible production of similar combining sites using different VH and VL germ-line genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb01559.x
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  • 2
    Electronic Resource
    Electronic Resource
    Choroid plexus papillomas (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 17 (1990), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1990.tb00701.x
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  • 3
    Electronic Resource
    Electronic Resource
    Malignant rhabdoid tumour of the uterus: an immunohistochemical and ultrastructural study (1992)
    Springer
    Virchows Archiv 420 (1992), S. 459-462 
    Details
    ISSN: 1432-2307
    Keywords: Malignant rhabdoid tumour ; Uterus ; Immunohistochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Malignant rhabdoid tumours (MRTs) are highly aggressive neoplasms which most frequently occur in the kidney of young children. Several cases of primary MRT occurring in extra-renal sites have been reported, particularly in the soft tissues. We report a case of primary MRT of the uterus, a very rare site for this neoplasm, with morphological, immunohistochemical and ultrastructural features corresponding to restrictive morphological criteria for MRT. The possible differential diagnoses were considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600519
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  • 4
    Electronic Resource
    Electronic Resource
    Rhabdoid tumours of the central nervous system (1993)
    Springer
    Virchows Archiv 422 (1993), S. 81-85 
    Details
    ISSN: 1432-2307
    Keywords: Rhabdoid tumour ; Central nervous system ; Immunocytochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three cases of rhabdoid tumour of the central nervous system arising in a supratentorial location are reported. The patients were 18, 14, and 7 years old. All three tumours showed a common morphology. The neoplastic cells were usually globoid with round nuclei and prominent nucleoli and large acidophilic, cytoplasmic inclusions were present in many of them. These inclusions showed strong immunoreactivity for vimentin, weak immunoreactivity for epithelial membrane antigen and focal immunoreactivity for cytokeratins. Ultrastructurally they were made up of whorls of intermediate filaments, 8–10 nm in thickness. Rhabdoid tumours of the central nervous system, whatever the cell of origin, appear to be an independent entity with identifiable histology and aggressive behaviour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605137
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  • 5
    Electronic Resource
    Electronic Resource
    The prevalence of BCL-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status (1994)
    Springer
    Virchows Archiv 424 (1994), S. 47-51 
    Details
    ISSN: 1432-2307
    Keywords: BCL-2 immunoreactivity ; Breast carcinoma ; Oestrogen receptors ; Progesterone receptors ; p53 accumulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract BCL-2 protein plays a pivotal role in overriding programmed cell death (apoptosis), thus favouring a prolonged survival of normal and neoplastic cells. Expression of the bcl-2 gene has been documented in some human tumours (non-Hodgkin's lymphomas and prostatic adenocarcinomas), but findings in breast carcinomas have not been reported. We have used the monoclonal antibody 124 to investigate BCL-2 expression in 212 breast carcinomas, and to correlate it with the oestrogen (ER), progesterone (PR) and epidermal growth factor receptor (EGFR) status, and with other clinicopathological variables including tumour type, grade, stage, growth fraction (as evaluated by Ki-67 immunostaining), and p53 accumulation. Of the 212 carcinomas, 173 (81.6%) exhibited BCL-2 immunoreactivity in more than 25% of the neoplastic cells. BCL-2 immunoreactivity was strongly correlated with ER and PR expression (P〈0.00001), with the lobular type (P=0.012) and with better differentiated neoplasms (P=0.00003), whereas it was inversely correlated with EGFR (P〈0.00001), p53 (P=0.0004) and Ki-67 (P=0.0002) immunoreactivities. No association was found with tumour stage (T and N categories). We conclude that bcl-2 expression in breast cancers is related to the oestrogen-dependent transcription pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197392
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  • 6
    Electronic Resource
    Electronic Resource
    Common acute lymphoblastic leukaemia-lymphoma expressing cytokeratin: a case report (1994)
    Springer
    Virchows Archiv 425 (1994), S. 83-87 
    Details
    ISSN: 1432-2307
    Keywords: Cytokeratin Acute lymphoblastic leukaemia ; lymphoma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report presents a case of common acute lymphoblastic leukaemia-lymphoma expressing low molecular weight cytokeratin but no leukocyte common antigen (CD45) in a 57-year-old man. The unusual morphology and clinical course together with the aberrant immunohistochemical results suggested a diagnosis of undifferentiated carcinoma. A detailed immunohistochemistry study on frozen and paraffin sections and molecular analysis prevented a diagnostic mistake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193954
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  • 7
    Electronic Resource
    Electronic Resource
    Infratentorial ischaemia following experimental cerebellar haemorrhage in the rat (1994)
    Springer
    Acta neurochirurgica 131 (1994), S. 146-150 
    Details
    ISSN: 0942-0940
    Keywords: Experimental cerebellar haemorrhage ; enzyme histochemistry ; blood flow ; hydrogen clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Early changes of cerebellar and cerebral blood flow, as well as subsequent infratentorial ischaemia, were evaluated in an experimental model of cerebellar haemorrhage. Eight anaesthetized male adult Sprague-Dawley rats received an injection of autologous arterial blood (50 μl) into the right cerebellar hemisphere. Eight animals were sham-operated and served as controls. Cerebellar blood flow, measured at regular time intervals in the hemispheric cortex ipsilateral to the lesion by the hydrogen clearance method, was significantly depressed in the experimental group as compared with the control animals. This drop in cerebellar blood flow was evident 5, 30, 60, 90, and 120 min postoperatively, with a return to pre-injection values recorded 180 min after surgery. No significant difference in supratentorial blood flow was detected over the entire period examined between the two groups of animals. Enzyme histochemistry demonstrated areas of ischaemia around the clot and within the brain stem in animals with an intracerebellar haemorrhage at the end of the experiment. These results provided evidence of ischaemic damage within the infratentorial compartment after the induction of experimental cerebellar haemorrhage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401465
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  • 8
    Electronic Resource
    Electronic Resource
    Muscle basal lamina as a grafting material for elongation of axons from rat brain (1991)
    Springer
    Acta neurochirurgica 109 (1991), S. 122-125 
    Details
    ISSN: 0942-0940
    Keywords: Axonal elongation ; central sprouting ; basal lamina ; nerve graft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autografts of peripheral nerve or allografts of muscle basal lamina were inserted into the putamen-caudate complex of rats, with the outer end of the implant being sutured to the temporalis muscle. Elongation of central axons within the grafts, as revealed by the horseradish peroxidase retrograde labelling technique, did occur in the presence of basal lamina implants. With both types of grafting materials stained neurones exhibited a comparable distribution, being mainly found in the proximity of the central tip of the grafts. However, labelled cells in the presence of basal lamina were limited in number, compared with peripheral nerve autografts. Therefore, the usefulness of implants of muscle basal lamina into the central nervous system, in order to direct regenerating central axons toward distant target regions, is limited. This material might be suitable, as an alternative grafting material, in experimental models where avoidance of neurological impairment or size and length of the graft are crucial factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403006
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  • 9
    Electronic Resource
    Electronic Resource
    Cortical blood flow recorded during early or delayed surgery for ruptured intracranial aneurysms (1994)
    Springer
    Acta neurochirurgica 131 (1994), S. 1-5 
    Details
    ISSN: 0942-0940
    Keywords: Cortical blood flow ; autoregulation index ; intracranial aneurysm ; subarachnoid haemorrhage ; timing of surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-three patients were operated on for ruptured intracranial aneurysms during a 12-month-period. Intraoperative evaluation of cortical blood flow by means of a thermal diffusion probe was performed in 23 out of the 41 patients who were operated on for aneurysms of the anterior circulation. The autoregulation index was determined at the time of raising the systemic blood pressure after clipping of the aneurysm(s). No statistically significant difference was found between the averages of the autoregulation indexes calculated in the subgroups of patients submitted respectively to early or delayed surgery. There was no correlation of both cortical blood flow and autoregulation with either age of the patients, or preoperative neurological grade. On the contrary, the autoregulation index showed a statistically significant correlation with outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401447
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  • 10
    Electronic Resource
    Electronic Resource
    Longitudinal study of cerebral blood flow following early or delayed surgery for ruptured intracranial aneurysms (1994)
    Springer
    Acta neurochirurgica 131 (1994), S. 6-11 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial aneurysm ; subarachnoid haemorrhage ; timing of surgery ; cerebral blood flow ; xenon133 inhalation technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Out of a series of 43 cases operated on for ruptured intracranial aneurysms over a 12-month-period, 32 patients were followed up to 12 months postoperatively with repeated evaluations of cerebral blood flow, using the Xenon133 inhalation technique. No statistically significant differences in cerebral perfusion were detected between the subgroups of good-grade patients, who were submitted respectively to early, or delayed surgery. Depression of flow in the affected hemisphere of poor-grade patients was principally related to the preoperative occurrence of an intracerebral haematoma. The overall results were not consistent with the hypothesis that early surgical intervention results in long-lasting effects on the cerebral circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401448
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