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  • 1
    Electronic Resource
    Electronic Resource
    Über den Dehydrogenase- und Diaphorase-Nachweis im Kleinhirn (1962)
    Springer
    Acta neuropathologica 1 (1962), S. 335-342 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The localization of DPNH- and TPNH-diaphorase, of SD, MDH, LDH, IDH, GDH and ADH has been studied in the human cerebellum and in the cerebella of several mammalia. The results of the reactions are rather uniform. In the molecular layer, in the Purkinje cells, in the glial satellite cells, in the „glomeruli cerebellosi” and in the central nuclei of cerebellum the reactions are most strongly positive. The differences in the intensity of the reactions for the various enzymes present in these morphological structures are discussed.
    Notes: Zusammenfassung Untersucht wurde die Lokalisation der DPNH- und TPNH-Diaphorase, der SD, MDH, LDH, IDH, GDH und ADH im Kleinhirn des Menschen und einiger Säugetiere. Die Ergebnisse der Reaktionen für alle Fermente sind ziemlich einheitlich. In der Molekularschicht, den Purkinje-Zellen, den gliösen Trabantenzellen, den „Glomeruli cerebellosi” und den zentralen Kleinhirnkernen zeigte sich die stärkste positive Reaktion. Die Unterschiede in der Intensität der Reaktionen für die verschiedenen Enzyme in diesen morphologischen Strukturen werden besprochen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687730
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  • 2
    Electronic Resource
    Electronic Resource
    Histochemische Untersuchungen über die Cholinesterase in Hirngeschwülsten (1962)
    Springer
    Acta neuropathologica 2 (1962), S. 73-85 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685745
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  • 3
    Electronic Resource
    Electronic Resource
    Histochemical study of the oxidative activity in tumors of the nervous system (1965)
    Springer
    Acta neuropathologica 4 (1965), S. 538-558 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die vorliegende Arbeit behandelt das histochemische Verhalten der Dehydrogenasen verschiedener Zelltypen in Tumoren des Nervensystems. Die von uns beobachteten Unterschiede in den Reaktionsergebnissen wurden nach den folgenden Gesichtspunkten untersucht: a) Beschreibung der histochemischen Reaktionen in den verschiedenen Tumortypen. b) Reaktionsunterschiede im Zusammenhang mit dem Differenzierungsgrad der Zellelemente, der embryonalen Grundlinien folgt. c) Reaktionsunterschiede in Abhängigkeit von Proliferationszonen mit zahlreichen atypischen Mitosen und ungenügender Zellreife. d) Unterschiede im Zusammenhang mit reaktiven oder regressiven Vorgängen.
    Notes: Summary The present research has pointed out some histochemical aspects of the oxidative metabolism of the various types of cells present in tumors of the nervous system. The variations in the reactions we observed were examined from the following points of view: a) Description of histochemical reactions in the various oncotypes. b) Variations in relation to the stage of differentiation of cellular elements, the evolution of which follows embryogenetic lines. c) Variations in relation to arrangements showing rapid growth with numerous and atypical mitoses and a deficient maturation of the cell. d) Variations in relation to reactive or regressive processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688513
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  • 4
    Electronic Resource
    Electronic Resource
    Muscle basal lamina as a grafting material for elongation of axons from rat brain (1991)
    Springer
    Acta neurochirurgica 109 (1991), S. 122-125 
    Details
    ISSN: 0942-0940
    Keywords: Axonal elongation ; central sprouting ; basal lamina ; nerve graft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autografts of peripheral nerve or allografts of muscle basal lamina were inserted into the putamen-caudate complex of rats, with the outer end of the implant being sutured to the temporalis muscle. Elongation of central axons within the grafts, as revealed by the horseradish peroxidase retrograde labelling technique, did occur in the presence of basal lamina implants. With both types of grafting materials stained neurones exhibited a comparable distribution, being mainly found in the proximity of the central tip of the grafts. However, labelled cells in the presence of basal lamina were limited in number, compared with peripheral nerve autografts. Therefore, the usefulness of implants of muscle basal lamina into the central nervous system, in order to direct regenerating central axons toward distant target regions, is limited. This material might be suitable, as an alternative grafting material, in experimental models where avoidance of neurological impairment or size and length of the graft are crucial factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403006
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  • 5
    Electronic Resource
    Electronic Resource
    Histochemische Untersuchungen über die Phosphorylasen in Hirngeschwülsten (1964)
    Springer
    Acta neurochirurgica 12 (1964), S. 475-485 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The G-l-P phosphorylase activity in different oncotypes of the nervous system has been studied using histochemical techniques. An increase of the activity is related to the degree of differentiation in an embryogenetic sense; whereas a decrease of the activity has been noticed in the atypical cellular forms. Further-more in all the oncotypes examined, the enzymatic activity is remarkable high in the reactive-hypertrophic cells.
    Abstract: Résumé Par des techniques histochimiques, nous avons étudié l'activité G-l-P phosphorylasique dans différents oncotypes du système nerveux central. Cette activité augmente parallèlement au processus de différentiation cellulaire dans le sens embryogénétique, et diminue parallèlement au processus de déviation vers des formes atypiques. De mÊme, dans tous les oncotypes examinés, l'activité enzymatique apparaÎt considérable dans les éléments cellulaires réactivo-hypertrophiques.
    Notes: Zusammenfassung Es wurde die G-l-P-Phosphorylase in den verschiedenen Hirngeschwülsten mit Hilfe histochemischer Methoden untersucht. Eine Vermehrung der AktivitÄt steht mit dem Differenzierungsgrad, im ontogenetischen Sinn, deutlich im Zusammenhang; dagegen veranla\t die maligne Entwicklung ein Abnehmen des Enzyms. Au\erdem ist stets eine Vermehrung der AktivitÄt im Zusammenhang mit reaktiven Prozessen der Zellen festzustellen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407223
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  • 6
    Electronic Resource
    Electronic Resource
    Cortical blood flow recorded during early or delayed surgery for ruptured intracranial aneurysms (1994)
    Springer
    Acta neurochirurgica 131 (1994), S. 1-5 
    Details
    ISSN: 0942-0940
    Keywords: Cortical blood flow ; autoregulation index ; intracranial aneurysm ; subarachnoid haemorrhage ; timing of surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-three patients were operated on for ruptured intracranial aneurysms during a 12-month-period. Intraoperative evaluation of cortical blood flow by means of a thermal diffusion probe was performed in 23 out of the 41 patients who were operated on for aneurysms of the anterior circulation. The autoregulation index was determined at the time of raising the systemic blood pressure after clipping of the aneurysm(s). No statistically significant difference was found between the averages of the autoregulation indexes calculated in the subgroups of patients submitted respectively to early or delayed surgery. There was no correlation of both cortical blood flow and autoregulation with either age of the patients, or preoperative neurological grade. On the contrary, the autoregulation index showed a statistically significant correlation with outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401447
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  • 7
    Electronic Resource
    Electronic Resource
    Tenascin distribution in human brain tumours (1995)
    Springer
    Acta neurochirurgica 136 (1995), S. 44-50 
    Details
    ISSN: 0942-0940
    Keywords: Brain tumours ; immunohistochemistry ; monoclonal antibody (mAb) ; tenascin (TN)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a monoclonal antibody specific for human tenascin (TN), 180 intracranial growths were immunohistochemically studied. In 69 cases of meningioma, neoplastic cells were negative, with some positivity being observed only in the perivascular and the supporting stroma, especially in anaplastic meningiomas. In 57 cases of glioma different degrees of reactivity occurred in both the cellular conglomerates and the stromal components of the tumours. A higher variability in reactivity was observed in anaplastic astrocytomas and glioblastomas. The most constant finding of the study was the staining of the stroma, which was observed in all types of growths, including metastasis, abscess and tuberculoma. The results are consistent with the hypothesis that tenascin is a stromal marker rather than a true marker of malignant tumours. The heterogeneous distribution of TN in anaplastic gliomas may be a factor in the variable response to treatment with radiolabelled anti-TN monoclonal antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411434
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  • 8
    Electronic Resource
    Electronic Resource
    A chemical approach to the problem of cellular malignancy in tumours of the nervous system (1966)
    Springer
    Acta neurochirurgica 15 (1966), S. 33-39 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Auf Grund verschiedener histocheruischer und mikrochemischer Untersuchungen an intrakraniellen Tumoren beschreiben die Autoren einige besondere metabolische Charakteristika und setzen sie in Beziehung zum Zelltyp, zu der Wachstumsgeschwindigkeit, zum Grad der Entdifferenzierung und zum Grad der Atypie. Die undifferenzierten neuroektodermalen Zellen zeigen ein metabolisches Verhalten, das in mehrerer Hinsicht von dem von atypischen Zellen abweicht. Man kann somit zwei verschiedene metabolische Schemata unterscheiden, eines der Atypie und das andere der Undifferenziertheit zugehörend. Die mögliche Bedeutung dieser Befunde in Beziehung zum Problem der Zellmalignität wird diskutiert.
    Abstract: Résumé A partir de plusieurs études histochimiques et microchimiques des tumeurs intracraniennes, les auteurs décrivent quelques caractères métaboliques particuliers relatifs à la lignée cellulaire, à la vitesse de croissance, au degré d'indifférenciation, et au degré d'atypie. Les cellules neuroectodermiques indifférenciées présentent plusieurs aspects métaboliques différents de ceux des cellules atypiques. Il est donc possible de reconnaÎtre deux schémas métaboliques différents: un relatif à l'atypie, et l'autre à l'indifférenciation. La signification de ces dècouvertes concernant le problème de la malignité cellulaire est discutée.
    Notes: Summary On the basis of several istochemical and microchemical researches on the intraoranial tumours, the A. A. describe some peculiar metabolic characters related to the cellular lineage, to the speed of growth, to the degree of undifferentiation and to the degree of atypia. The undifferentiated neuroectodermic cells show a metabolic pattern differing in several respects from that of the atypical cells. It is thus possible to recognize two different metabolic schemata: one related to atypia, the other one to undifferentiation. The possible meaning of these findings in relation to the problem of cellular malignancy is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405067
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  • 9
    Electronic Resource
    Electronic Resource
    Cerebral water and electrolytes in experimental ischaemia following omental transposition to the brain (1980)
    Springer
    Acta neurochirurgica 54 (1980), S. 213-218 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Occlusion of the middle cerebral artery induces a local decrease in percentage of tissue dry weight in rabbit brain, associated with flux of sodium and potassium in reciprocal directions. Cortical swelling occurs also in remote non-ischaemic areas. Previous transposition of the omentum majus to the brain minimizes the onset of oedema consequent on occlusion of a major cerebral artery. Increasing experimental evidence points to the role of omental transposition in providing an effective source of collateral circulation, thus strongly affecting the threshold for infarction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407088
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  • 10
    Electronic Resource
    Electronic Resource
    Further remarks on the surgical treatment of carotid-choroidal aneurysms (1971)
    Springer
    Acta neurochirurgica 24 (1971), S. 253-262 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Riassunto L'ulteriore personale esperienza sugli aneurismi della giunzione carotidecorioidea anteriore permette di prospettare la possibilità che la salvaguardia dell'arteria corioidea anteriore, benchè importante, non costituisca un problema di assoluta necessità. Nella serie degli Autori, infatti, solo un caso sui quattro con occlusione chirurgica dell'arteria corioidea ha presentato transitori disturbi post-operatori attribuibili all'occlusione stessa; d'altra parte, analoghi transitori disturbi — attribuibili ad uno spasmo dell'arteria — sono comparsi anche in un caso dei sei con la corioidea intatta. Gli Autori, quindi, pur riconoscendo l'opportunità di evitare l'occlusione chirurgica della corioidea anteriore, sono del parere che ove ciò non sia possibile, i risultati possono essere egualmente buoni.
    Notes: Summary Further experience with carotid-choroidal aneurysms leads the authors to believe that whilst it is desirable to safeguard the anterior choroidal artery it is not always essential. In this series, only one out of four patients with a surgical occlusion of the choroidal artery had transient post-operative troubles. Of six patients with an intact choroidal artery, one showed transitory post-operative troubles, which were ascribed to spasm of the vessel. It is concluded that although care should be taken to avoid choroidal artery occlusion, when it must be occluded in order to treat the associated aneurysm, a neurological deficit does not inevitably occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405411
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