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  • 1
    Electronic Resource
    Electronic Resource
    Bail-Out Stenting With Medtronic Wiktor™: Results from the European Stent Study Group (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of interventional cardiology 7 (1994), S. 0 
    Details
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8183.1994.tb00495.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immune thrombocytopenia associated with hemorrhagic diathesis due to ibuprofen administration (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 413-415 
    Details
    ISSN: 1432-1440
    Keywords: Ibuprofen thrombocytopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute thrombocytopenic purpura temporally related to the oral administration of ibuprofen developed in a patient with ankylosing spondylitis. Clinical manifestations, with sudden onset occurring within t2 h of drug ingestion and rapid increase of platelet counts following discontinuation of the drug, were characteristic of an antibody-mediated immune pathomechanism. Immunological studies demonstrated IgM and IgG antibodies in the patient's serum that were capable of binding to allogenic platelets in the presence of a metabolite preparation. This finding suggested that an ibuprofen metabolite, rather then the drug itself, was the antigenic agent responsible for the immune reaction. Despite its widespread therapeutic use, ibuprofen has not been described previously as causing immune-mediated thrombocytopenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186632
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Severe granulomatous giant cell myocarditis in Wegener's granulomatosis (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 880-885 
    Details
    ISSN: 1432-1440
    Keywords: Wegener's granulomatosis ; Granulomatous giant cell myocarditis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 28-year-old male patient suffering from Wegener's granulomatosis died suddenly with signs of cardiac failure after clinical symptoms had basically subsided under chemotherapy. Autopsy revealed pulmonary granulomata, necrotizing vasculitis of the lungs and kidneys, focal and segmental necrotizing glomerulonephritis, and diffuse granulomatous and necrotizing giant cell myocarditis. Histological confirmation of inflammation of the heart in Wegener's disease has rarely been reported. Although cardiac involvement in Wegener's granulomatosis sometimes is suspected, it is usually thought to have no major impact on the course of the disease. By its dramatic clinical and morphologic presentation this case illustrates that the heart, in addition to the lungs and kidneys, may determine the outcome of the idiopathic granulomatous vasculitis of Wegener.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01662788
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Enteroviral infection in end stage dilated cardiomyopathy (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 914-920 
    Details
    ISSN: 1432-1440
    Keywords: Dilated cardiomyopathy ; Enteroviruses ; Nucleic acid hybridization ; Heart transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to evaluate the role of enteroviral infections in end stage dilated cardiomyopathy, RNA was isolated from left ventricular myocardium of patients with dilated cardiomyopathy explanted during heart transplantation (n=6) and from control hearts (n=8), then probed using a dot blot procedure with two well-defined enteroviral cloned cDNA probes. One of the cardiomyopathic heart samples hybridized with the enteroviral probes, while RNA samples from the other diseased heart and the control heart demonstrated no hybridization. To verify further the enteroviral infection, a cDNA prepared from the positive heart RNA hybridized with Southern blotted coxsackievirus B3 and poliovirus 1 nucleotide sequences, while a control sample, which gave negative results in the dot blot, showed no hybridization to the enteroviral sequence. These results provide evidence for an enteroviral infection in certain patients with end stage dilated cardiomyopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649038
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Antiproliferative effects of a c-myc antisense oligonucleotide on human arterial smooth muscle cells (1992)
    Springer
    Basic research in cardiology 87 (1992), S. 585-591 
    Details
    ISSN: 1435-1803
    Keywords: Humanarterial smooth musclecells ; proliferation ; antisenseoligonucleotides ; c-myc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of a c-myc antisense phosphorothioate DNA oligonucleotide were assessed on the proliferation rate of human arterial smooth muscle cells (HSMCs). Compared to a control oligonucleotide the antisense oligonucleotide suppressed the proliferation of HSMCs in a concentration-dependent manner without a major cytotoxic effect. Outgrowth of HSMCs from media explants was significantly inhibited as well. Induction of c-myc expression by serum stimulation of cells was blunted by the antisense oligonucleotide, as shown by immunoblotting. These results demonstrate that c-myc expression is an essential factor for proliferation of HSMCs after growth stimulation, and they show the potential of antisense technology for modulating gene expression of HSMCs in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788668
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    Paper (German National Licenses)
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