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  • 1990-1994  (8)
  • 1
    Electronic Resource
    Electronic Resource
    Ambidextrous RNA (1990)
    [s.l.] : Nature Publishing Group
    Nature 348 (1990), S. 491-492 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-John Galloway, in his discussion in News and Views' of Brown and Wolpert's paper2 on asymmetry in development, states that molecular determinants are unlikely to be involved. He points out that the structure of individual proteins is either right- or left-handed and that gene mutation could not ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/348491b0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Of mice and men (1992)
    [s.l.] : Nature Publishing Group
    Nature 360 (1992), S. 305-305 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Increasing numbers of transgenic mice are now being generated which have heterozygous or homozygous nonfunctional genes known to be important in humans. There is also a strong expectation in the current literature that mice and men should have essentially the same molecular and cellular ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/360305b0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gene silencing in mammalian cells by uptake of 5-methyl deoxycytidine-5′-triphosphate (1991)
    Springer
    Somatic cell and molecular genetics 17 (1991), S. 537-542 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Chinese hamster ovary (CHO) cells were subjected to electroporation in the presence of 5-methyl deoxycytidine-triphosphate. This treatment increases by 10 to 100-fold the frequency of cells lacking thymidine kinase, hypoxanthine-guanine phosphoribosyltransferase, or adenine phosphoribosyltransferase. The inactivation of the genes coding for these enzymes is thought to occur following the direct incorporation of the methylated nucleotide triphosphate into DNA. The enzyme-deficient clones were stable, but almost all were reactivated at high frequency by the demethylating agent 5-azacytidine, to produce derivatives with enzyme activity. The results indicate that there is a direct relationship between DNA methylation and gene silencing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01233618
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Is DNA methylation of X chromosome genes stable during aging? (1991)
    Springer
    Somatic cell and molecular genetics 17 (1991), S. 101-103 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01233210
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Correspondence (1994)
    New York, NY : Wiley-Blackwell
    BioEssays 16 (1994), S. 591-595 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950160815
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Roots: The history of the DNA heteroduplex (1990)
    New York, NY : Wiley-Blackwell
    BioEssays 12 (1990), S. 133-142 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950120309
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Specificity in splicing (1994)
    New York, NY : Wiley-Blackwell
    BioEssays 16 (1994), S. 771-774 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Considerable information about the process of premRNA splicing has accmulated, but the mechanism by which highly accurate splicing is achieved is unresolved. Fifteen years ago we proposed that accuracy in splicing might depend on small RNA molecules (splicer RNAs) which hybridise across adjacent exon termini, or intron termini. Gene expression, including alternative splicing, could be controlled by the transcription of specific splicer RNA genes. We re-assess our model here, in the light of subsequent developments.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950161013
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Epigenetics: An overview (1994)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 15 (1994), S. 453-457 
    Details
    ISSN: 0192-253X
    Keywords: Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020150602
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    Paper (German National Licenses)
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