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  • 1985-1989  (5)
  • 1980-1984  (5)
  • 1970-1974  (1)
Materialart
Erscheinungszeitraum
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 511 (1987), S. 0 
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Notizen: The glycosylated and the non-glycosylated recombinant human granulocyte-macrophage colony-stimulating factor (rh GM-CSF) expressed in Chinese hamster ovary cells and E. coli, respectively, were administered in rhesus monkeys either by the subcutaneous (three times daily) or intravenous route (6-hr infusions) for seven consecutive days. Within 24 hr peripheral white blood cells (WBC) increased 2-3-fold over normal values. Thereafter, the WBC increased steadily in a dose-dependent manner to reach maximum levels on the last day of or one day after the treatment period. The differential counts showed that neutrophils contributed to 50-80%, eosinophils to 10-20%, monocytes to 2-7%, and lymphocytes to 15–30% of the WBC rise. No effect was found on platelets and erythrocytes. After termination of treatment, WBC counts returned to normal levels within one week. Subcutaneously administered CSF was more effective in inducing leukocytosis than that injected intravenously. In addition to the rise in WBC, the administered rh GM-CSF also enhanced the oxidative metabolism and bactericidal activity of the circulating mature granulocytes isolated from the blood of monkeys treated with rh GM-CSF. These results show that glycosylated or non-glycosylated rh GM-CSF is both an effective stimulator of leukocytosis and a potent activator of the functional activity of mature granulocytes in vivo.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 18 (1982), S. 0 
    ISSN: 1752-1688
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Notizen: : A new computation method is developed for the bottom withdrawal tube particle size analysis. A transformation on time scale is introduced so that the cumulative percentage of a selected particle size can be determined from a single continuous Oden cum.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 24 (1984), S. 0 
    ISSN: 1574-6968
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Abstract Twelve enteric bacterial strains were recovered by differential centrifugation of urines which were collected from clinically diagnosed and microbiologically confirmed cases of urinary tract infection. The outer membrane protein (OMP) profiles of the clinical isolates were then analysed by sodiumdodecylsulphate-polyacrylamide gel electrophoresis (SDS-PAGE). It was found that 5 of the 12 isolates (3 Escherichia coli strains, 1 Klebsiella pneumoniae and 1 Proteus mirabilis strain) expressed 2 or more high Mr proteins in the range of 66000 to 85000. These high Mr proteins were expressed by the same organisms during growth in vitro in iron-restricted conditions but not in iron-sufficient media.In addition, it was found that the major outer membrane proteins expressed by the clinical isolates varied considerably and that, in many cases, fresh isolates expressed fewer porin proteins than the same bacterial strains after growth in vitro in trypticase soy broth. This is thus the first evidence the E. coli, K. pneumoniae and P. mirabilis grow under iron-restricted conditions in the urinary tract of humans and that the outer membrane protein profile of clinical isolates differ from in vitro grown bacteria.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    BIT 21 (1981), S. 294-304 
    ISSN: 1572-9125
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract In this paper, a quadratic programming model is developed to take into consideration a number of factors that can influence the process of optimal allocation of data among the nodes in a distributed database. The factors include communication costs, translation costs, congestion costs and storage costs. Beale's method is used to solve the resulting quadratic program. Some numerical examples are presented and the potentials of such an approach in the design and analysis of distributed databases are discussed.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Il nuovo cimento della Società Italiana di Fisica 10 (1988), S. 247-276 
    ISSN: 0392-6737
    Schlagwort(e): Boson degeneracy and superfluidity of helium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Beschreibung / Inhaltsverzeichnis: Riassunto Impiegando la teoria della matriceU nella forma presente, abbiamo presentato una teoria microscopica di un sistema interagente diN bosoni a temperatura non nulla. L'hamiltoniana include un termine che descrive l'influenza esterna, un termine per un'interazione a 2 particelle e une che riguarda l'interazione di tipo dipolare. Per studiare lo stato fondamentale dell'4He liquido s'include solo l'interazione a 2 particelle. Basandoci su dati di scattering, abbiamo dedotto la funzione potenziale a 2 particelle. Con quella, calcoliamo numericamente la distribuzione dell'impulso aT=1.1K per diversi gruppi di parametri. Si mostra che le curve teoriche sono in buon accordo con i risultati osservati. Le corrispondenti curve del fattore di struttura del liquido si adattano benissimo ai dati misurati e il risultato migliore per l'energia dello stato fondamentale è − 7.12K.
    Kurzfassung: Резюме Используь теориюU-матрицы, мы предлагаем микроскопическую теорию взаимодеюствующейN-бозонной системы при ненулевых температурах. Гамильтониан включает член, описывающий внешнее влияние, член двух-частичного взаимодействия и член, относящийся к дипольному типу взаимодействия. При исследовании основного состояния шидкого4He учитяватся только двух-частичное взаимодействие. Основываясь на данных по рассеянию, мы выводим двух-частичную потенциальную функцию. Мы численно определяем распределение по импульсам приT=1.1K для некоторых систем параметров. Показывается, что теоретические кривые согласуются с наблюденными результатами. Соответст вующий структурный фактор зидкости хорошо согласуется с экспериментальными данными. Полученная величина энергии основного состояния составляет −7.12 K.
    Notizen: Summary Employing theU-matrix theory in the present form we have presented a microscopic theory of an interactingN-boson system at nonzero temperature. The Hamiltonian includes a term describing the external influence, a term for a two-particle interaction and one pertaining to the dipole-type interaction. To study the ground state of liquid4He, only the two-particle interaction is included. Based on scattering data, we have deduced the two-particle potential function. With that we calculate numerically the momentum atT=1.1 K for several sets of parameters. It is shown that the theoretical curves agree well with the observed results. The corresponding liquid-structure-factor curves fit the measured data very well and the best result for the ground-state energy is −7.12K.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Il nuovo cimento della Società Italiana di Fisica 10 (1988), S. 915-932 
    ISSN: 0392-6737
    Schlagwort(e): Quantum effects on the structure and dynamics of nondegenerate fluids
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Beschreibung / Inhaltsverzeichnis: Riassunto In questo lavoro si applica la teoria della matriceU per dedurre un'espressione esplicita per lo spettro d'energia di eccitazione dell'4He liquido. Usando un modello per il potenziale chimico efficace per l'4He si è in grado di produrre uno spettro di eccitazione molto simile a quello osservato. L'inverso della massa efficace, cioè 1/m *, è ottenuto in funzione del momentok. Si trova che il rapporto tra massa efficace e la massa dell'atomo di elio ak=2.0 Å−1, cioè vicino alla profondità del rotore, èm * (k=2.0 Å−1)/m He= =0.18298, mentre quello ak=1.0 Å−1 èm * (k=1.0 Å−1)/m he=−0.17103. Il risultato teorico dello spettro di eccitazione è coerente con i dati sperimentali.
    Kurzfassung: Резюме В этой статье мы применяем теориюU-матрицы для вывода явного выражения для энергетического спектра возбуждений Зидкого4He. Используя модель для эффективного химического потенциала для4He, мы воспроизводим спектр возбуждений который оказывается очень близким к зкспериментально наблюдаемому. Вычисляется обратная величина эффективной массы, т.е. 1/m *, как функция импульсаk. Получено отношение эффективной массы к массе атома гелия приk=2.0 Å−1, которое составляетm * (k=2.0 Å−1)/m He=0.18298, тогда как это отношение приk=1.0 Å−1 равноm * (k=1.0 Å−1)/m He=−0.17103. Теоретический результат для спектра возбужений согласуется с имеющимися экспериментальными данными.
    Notizen: Summary In this paper, we apply theU-matrix theory to derive an explicit expression for the excitation energy spectrum of liquid4He. Using a model for the effective chemical potential for4He, we are able to produce an excitation spectrum which is very close to the observed one. The inverse of the effective mass,i.e. 1/m *, is obtained as a function of momentumk. The ratio between the effective mass and the mass of helium atom atk=2.0 Å−1,i.e. near the roton depth, is found to bem *(k=2.0 Å−1)/m He=0.18298, while the ratio atk=1.0 Å−1 ism *(k=1.0 Å−1)/m He=−0.17103. The theoretical result of the excitation spectrum is consistent with observational data.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 246 (1973), S. 419-421 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Fig. 1 a, The structure found for homogeneous yCD proteins; b, that of human IgG. IgG consists of two y chains and two light chains, joined by interchain bonds . .. ., and cleaved by papain into one Fey and two Faby fragments as depicted. The heavy lines show the sequences represented in yCD ...
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Journal of low temperature physics 44 (1981), S. 259-264 
    ISSN: 1573-7357
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Two new internal friction peaks have been observed in single-crystal silicon in the temperature range from 100 to 270 K of the Arrhenius-type relaxation at kilohertz frequencies. The activation energies of the two peaks are 0.14 and 0.20 eV. We attribute them to vibration of trapped interstital oxygen and the oxygen-vacancy complex, respectively.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    ISSN: 1439-0973
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die komplementbedingte Opsonierungsaktivität (CMOA) in Intraabdominalexsudaten, gewonnen während der Laparotomie von Peritonitispatienten, wurdein vitro an einem Phagozytosemodell untersucht. Es zeigte sich, daß infektiöse Intraabdominalexsudate die Abtötung vonEscherichia coli O1 durch polymorphkernige Leukozyten kaum fördern. Bakterien, mittels Differentialzentrifugation aus infizierten Exsudaten gewonnen, wiesen nur zu einem geringen Teil C3 auf ihrer Oberfläche auf. Diese Organismen wurdenin vivo nicht optimal opsoniert, während siein vitro nach kurzer Inkubationszeit in normalem Humanserum mit C3 vollständig beladen werden konnten. Der geringe Gehalt an C3 im Peritoneum kommt einer Verringerung von Komplement im Blut gleich. Dementsprechend war die CMOA bei Septikämien, bedingt durch gramnegative Organismen, extrem niedrig. Die Ergebnisse lassen vermuten, daß die hohe Anfälligkeit des Peritoneums für Infektionen durch Keime der Darmflora zum Teil mit dem niedrigen Gehalt an Komplement erklärt werden kann, der eine ausreichende Opsonierung der Bakterien nicht gewährleistet.
    Notizen: Summary The complement-mediated opsonic activity (CMOA) in intra-abdominal exudates collected during laparotomy from peritonitis patients was examined by anin vitro phagocytic bactericidal assay. It was found that infected intra-abdominal exudates barely promoted detectable killing ofEscherichia coli 01 by polymorphonuclear leukocytes. Only the minority of bacteria recovered by differential centrifugation from the infected exudates had C3 on their surfaces. Such bacteria were not optimally opsonizedin vivo, whereas they became fully coated with C3 during a brief incubationin vitro in normal human serum. The low level of CMOA in the peritoneal fluid paralleled a depletion of complement in the peripheral blood. Thus, in cases complicated by sepsis with gram-negative bacteria, the CMOA in the blood was extremely low. These data suggest that the high susceptibility of the peritoneum to infection by gut flora, despite the normal phagocytic response, may be partly explained by the low local level of functional complement which is inadequate for optimal opsonization of the bacteria.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical microbiology & infectious diseases 4 (1985), S. 279-281 
    ISSN: 1435-4373
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In an attempt to inhibit the biosynthesis of the type-specific M protein usually expressed on surface fimbriae group AStreptococcus pyogenes Δ 2305 was cultivated in Todd-Hewitt broth containing 10 % human serum and subinhibitory concentrations of either josamycin, erythromycin or clindamycin. Electron microscopy revealed that the antibiotic-pretreatment had little visible effect on the surface structures of the streptococci. However, josamycin and clindamycin-pretreated bacteria adhered less to hydrophobic gels than erythromycinpretreated or untreated control cultures. Due to the decrease in surface hydrophobicity, the drug-pretreated bacteria also activated complement more readily and fixed more C3 on their surface. Consequently the killing of josamycin and clindamycin-pretreated bacteria by polymorphonuclear leucocytes was significantly enhanced. Similar findings were obtained when the M protein was removed from the bacteria by digestion with trypsin. These results suggest that josamycin, like clindamycin, reverses the capacity of group A streptococci to resist opsonization by normal human serum and interferes with the adhesion of the organisms to host epithelial cell surfaces.
    Materialart: Digitale Medien
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