ISSN:
1432-0584
Keywords:
Blast foci
;
Clonal cytogenetic abnormalities
;
Clonal evolution
;
Karyotype shift
;
“Myeloblasts”
;
Myelodysplastic syndromes
;
Survival
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Two independent observers performed a double review of cytological and histological bone marrow material obtained at diagnosis and during follow up in 34 patients with the myelodysplastic syndrome (MDS), subtypes refractory anaemia (RA) and RA with ringed sideroblasts (RA-S) (26 and 8 patients, respectively). Average values were used for the analyses. Data obtained at diagnosis confirmed earlier observations that a worse prognosis was indicated by high blast cell counts (P〈0.01), presence of blast foci and clonal cytogenetic abnormalities (P=0.08). Data obtained during follow up, in addition, showed that an increased probability of progression to FAB-subtype RA with an excess of blasts was related to both the occurrence of blast foci (P〈0.05) and the occurrence of new or additional clonal abnormalities (karyotype shift) (P〈0.01). The relationship between parameters investigated at diagnosis, during follow up, and in the pooled material, points to RA-S being a separate entity having a better prognosis than RA, and further substantiates an earlier observed relationship between blast cell accumulation and the frequency of cytogenetically abnormal metaphases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00594199
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