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  • 1
    Electronic Resource
    Electronic Resource
    Electron-impact dissociation of H3O+ (1986)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 85 (1986), S. 3386-3394 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Fragment cross sections for electron impact dissociation of H3O+ into OH+ and O+, and for dissociation of D3O+ into D2O+ have been measured in a crossed beam appartus for electron energies from threshold to 1000 eV. The cross sections for O+ and OH+ rise abruptly at threshold indicating that the mechanism for dissociation is via production of an electronically excited state of H3O+ and direct dissociation into O+ and OH+. At high energy the cross section has a falloff σ∝ln(E)/E expected in the Bethe-Born approximation. At 200 eV electron energy the cross sections for fragments are: D2O+, σ=6.7±1.8×10−17 cm2; OH+, σ=3.0±0.6×10−17 cm2; O+, σ=7.9±1.6×10−18 cm2. The observed threshold energies for OH+ and O+ production are 14±3 and 19±3 eV, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.450960
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrahigh resolution spectroscopy of C2−: The A 2Πu state characterized by deperturbation methods (1985)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 82 (1985), S. 1723-1731 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Spectra of the C2− B 2Σu+–X 2Σg+ transition have been obtained using a merged laser-ion beam spectrometer with sub-Doppler resolution. Strong perturbations of the B state by the previously unobserved A 2Πu state are analyzed to obtain the characteristics of the new state. The A state spectroscopic constants in wave numbers (with estimated standard errors) are found to be Te=4060±180, ωe=1656±20, ωexe=10.80±0.50, Be=1.630±0.005, and A=−24±1. All nine perturbations observed in this work and the five observed in the work of Herzberg and Lagerqvist are explained by the interaction of the A 2Πu state with the B state. These results, as well as the perturbation matrix elements, are compared with theoretical estimates and results for isoelectronic 13-electron species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.448960
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  • 3
    Electronic Resource
    Electronic Resource
    Charge exchange of N2+2 with Ar (1985)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 83 (1985), S. 5673-5676 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The charge exchange of N2+2 is distinguished from charge exchange of N+ in the measurement of the differential cross section. N2+2 charge exchanges with argon to produce predominantly Ar+ in its ground state and N+2 in its C 2Σ+u and D 2Π states. A vibrational progression is observed corresponding to the vibrational frequency in the C state. Also observed is the charge exchange of N+2(A 2Πu). A simple model is used to explain the data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.449641
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  • 4
    Electronic Resource
    Electronic Resource
    Two-step barrier diodes (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 52 (1988), S. 960-962 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Transmission probabilities and current densities of a two-step barrier heterostructure are calculated within the effective-mass approximation as a function of electron energy and applied bias. This system shows negative differential resistance under forward bias, because of a quasibound state in a triangular well, and no resonance under reverse bias, in the current density. The two-step barrier diode may show negative resistance in an ac field in the absence of a dc bias.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.99241
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 211-214 
    Details
    ISSN: 1432-1041
    Keywords: heparin ; protein binding ; phenytoin ; prazosin ; lipases ; plasma triglycerides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of low doses of heparin on the binding of phenytoin and prazosin to plasma proteins was evaluated in four normal subjects. Heparin activates the hydrolysis of triglycerides in plasma. The ensuing increase in non-esterified fatty acids (NEFA) was more marked in vitro than in vivo and increased the free fraction (FF) of phenytoin and prazosin in plasma. The higher FF caused a change in the plasma to whole blood ratio (P/B ratio) of both drugs. The changes in FF and P/B ratio after heparin were small, but could be of significance in pharmacokinetic studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543793
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of the time of administration of dexamethasone 0.25 MG on cortisol secretion in normal humans (1986)
    Springer
    Psychopharmacology 89 (1986), S. 293-295 
    Details
    ISSN: 1432-2072
    Keywords: Dexamethasone suppression test ; Chronobiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Single low doses (0.25 mg) of dexamethasone were given at 11 p.m., 2, 5 and 8 a.m. on separate days to five normal subjects. The concentrations of cortisol in plasma on the next day were significantly decreased compared to results after placebo administration, and cortisol suppression was maximal after dexamethasone had been given at 8 a.m. Our findings suggests that the postulated phase-advance of circadian rhythms is not a major cause of cortisol non-suppression in depressives given dexamethasone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174362
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Der Einfluß von Fremdgasen auf die hohen Hauptserienlinien des Natriums (1935)
    Springer
    The European physical journal 97 (1935), S. 699-707 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Es wird dieVerbreiterung der Linien des Natriumserienendes durch Helium, Neon, Argon, Wasserstoff und Stickstoff gemessen. Bei allen Gasen sinkt die Breite mit der Seriengliedzahl und nimmt schließlich einen konstanten Grenzwert an. Der Endwert ist als unabhängig vom absorbierenden Alkali anzusehen und hängt nur vom Fremdgas ab. Vom Helium abgesehen wachsen die Endbreiten der Edelgase wie die Grenzverschiebungen mit der Ordnungszahl. Die Wirkung der Gase ist am Serienende eine ganz andere als am Serienanfang. Die vorhandenenUnsymmetrien gehen nach Rot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01342423
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  • 8
    Electronic Resource
    Electronic Resource
    Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 232 (1982), S. 215-222 
    Details
    ISSN: 1433-8491
    Keywords: Amitriptyline ; Nortriptyline ; Hydroxylated metabolites ; Oxidation polymorphism ; Hydroxylation polymorphism ; Pharmacogenetics ; Interindividual differences ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have measured the metabolites (demethylated and hydroxylated) of amitriptyline in a group of seven normal volunteers. They were phenotyped as extensive or poor metabolizers using debrisoquine and bufuralol. The results demonstrate that the oxidative metabolism (aliphatic hydroxylation) of amitriptyline is under the same genetic control as that of debrisoquine and bufuralol. However, phenotypic polymorphism cannot be used to predict amitriptyline blood concentration after a single oral dose, since the principal metabolic pathway of amitriptyline is demethylation and not aliphatic hydroxylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02141782
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  • 9
    Electronic Resource
    Electronic Resource
    Elimination and pharmacological effects following single oral doses of 50 and 75 mg of amitriptyline in man (1983)
    Springer
    European archives of psychiatry and clinical neuroscience 233 (1983), S. 449-455 
    Details
    ISSN: 1433-8491
    Keywords: Amitriptyline ; Nortriptyline ; Hydroxylated metabolites ; Linear disposition ; Interindividual differences ; Pharmacological effects ; Psychomotor tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a companion paper we described the disposition of a 75 mg single dose of amitriptyline in normal volunteers who were phenotyped as extensive or poor metabolizers of debrisoquine and bufuralol, and had a four-fold range in the oral clearance of the antidepressant, 50 mg of amitriptyline was also administered to the same volunteers. This paper compares the results after both doses and suggests that the disposition of amitriptyline is linear even in subjects with a low oral clearance. There was no relation between the pharmacokinetic data and the intensity of sedation or of psychomotor impairment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342785
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  • 10
    Electronic Resource
    Electronic Resource
    Prescribing patterns in an outpatient psychiatric clinic (1984)
    Springer
    European archives of psychiatry and clinical neuroscience 234 (1984), S. 220-223 
    Details
    ISSN: 1433-8491
    Keywords: Psychotropic drugs ; Prescribing patterns ; Drug utilization ; Psychiatric outpatients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prescribing patterns were studied in a psychiatric outpatient clinic. Psychiatrists tended to prescribe large quantities of antidepressants or other drugs. In contrast, the daily doses for antidepressants and neuroleptics were often too low. Significant variations were noted between three outpatient clinics in the choices among a various psychotropic drugs from a given therapeutic group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381352
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