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  • 1985-1989  (4)
  • 1980-1984  (2)
  • 1925-1929  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 28 (1989), S. 9508-9514 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 23 (1984), S. 4409-4416 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 49 (1927), S. 1284-1289 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 85 (1986), S. 4195-4197 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A tunable infrared diode laser was used to study the nascent rotationa distribution of CO2 molecules produced directly in the 0001 excited state as a result of collisions with hot hydrogen atoms formed in the UV photolysis of H2S.(AIP)
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les résultats de l'anastomose iléo-terminale en aval d'un réservoir iléal sont variables, les selles pouvant Être fréquentes, rares ou absentes. Pour déterminer les facteurs physiologiques (extensibilité du réservoir et motilité) et anatomiques (forme du réservoir et proximité de l'anus) susceptibles d'expliquer ces variations, les auteurs ont créé chez le chien à l'aide de l'iléon un réservoir en forme de S ou en double cylindre, la continuité avec l'anus étant rétablie soit directement soit par l'intermédiaire d'un conduit iléal de 2 cm ou d'un conduit plus long de 6 cm. La réalisation de l'un ou de l'autre de ces réservoirs se traduit par l'emmagasinement du bol fécal, le prolongement du temps de transit intestinal et la réduction du temps de fréquence des selles par rapport à l'anastomose iléale anale directe sans réservoir. L'électromyographie et la manométrie révèlent que la répétition des contractions péristaltiques simultanées des deux ou trois branches d'iléon formant les 2 types de réservoir est indispensable pour engendrer les vagues de pression intra-luminales nécessaires au déclenchement de l'évacuation complète du réservoir. Ces contractions simultanées se manifestent moins souvent au niveau du réservoir en forme de S qu'au niveau du réservoir en double cylindre. En six mois, le réservoir en forme de S devient un élément inerte, obstructif. Par ailleurs, l'interposition du conduit iléal entre les réservoirs et l'anus facilite la réalisation de l'opération, mais lorsque sa longueur est supérieure à 2 cm, l'évacuation du bol fécal est gÊnée. En conclusion, le réservoir à double cylindre est supérieur au réservoir en forme de S, ses caractères physiologiques (extensibilité et contractibilité) se rapprochant de ceux du rectum normal, à condition qu'il soit situé près de l'anus (2 cm).
    Abstract: Abstracto Los resultados finales después de anastomosis íleoanal con un reservorio ileal proximal varían desde frecuencia defecatoria hasta obstrucción. Con el objeto de definir los determinantes fisiológicos (capacitancia funcional del reservorio, motilidad) y anatómicos (diseño del reservorio, proximidad anal) del variable resultado clínico, construímos en perros reservorios en forma de S (SS-R) o de doble luz (DB-R) en continuidad con el ano, directamente o vía conductos ileales de 2 cm y 6 cm. En virtud de una mayor capacitancia funcional cualquiera de los dos reservorios los mismos permiten almacenamiento fecal, prolongan el tiempo de trámite intestinal y mejoran la frecuencia defecatoria que se observa después de anastomosis íleoanales. La electromiografía y la manometría revelan que se requieren contracciones peristálticas simultáneas, repetitivas, de 2 y 3 asas ileales que forman el DB-R y SS-R, respectivamente para generar las ondas de presión intraluminal necesarias para promover la evacuación completa del reservorio. Tales contracciones simultáneas ocurren con menor frecuencia en el SS-R que en el DB-R. Por consiguiente, el SS-R se convierte en un viscus inerte, que produce obstrucción en el curso de 6 meses, lo cual no se observa con el DB-R, el cual es más fuerte desde el punto de vista peristáltico. Los conductos ileales facilitan la colocación del reservorio, pero cuando son de una longitud mayor de 2 cm, éstos impiden la evacuación del reservorio y predisponen a la obstrucción. Hemos concluído que, en contraste con el SS-R, el DB-R posee características fisiológicas (capacitación funcional y contractilidad) que permiten hábitos intestinales normales, pero sólo si es colocado en proximidad anatómica del ano.
    Notes: Abstract End results after ileoanal anastomosis with a proximal ileal reservoir range from defecatory frequency to obstruction. To define the physiological (reservoir compliance, motility) and anatomical (reservoir design, anal proximity) determinants of the varying clinical outcome, we placed an S-shaped (SS-R) or double-barreled (DB-R) reservoir in comtinuity with the anus in dogs, either directly or via 2-cm or 6-cm ileal conduits. Because of increased compliance, either reservoir provides for fecal storage, prolongs intestinal transit time, and alleviates the defecatory frequency seen after direct ileoanal anastomosis. Electromyography and manometry revealed that repetitive, simultaneous peristaltic contractions of the 2 and 3 ileal limbs forming the DB-R and SS-R, respectively, are required to generate the intraluminal pressure waves necesssary to promote complete reservoir evacuation. Such simultaneous contractions occur less often in the SS-R than in the DB-R. Therefore, the SS-R develops into an inert, obstructing viscus within 6 months, which is not seen with the peristaltically stronger DB-R. Ileal conduits facilitate reservoir placement; but, when longer than 2 cm, they impede reservoir evacuation and predispose to obstruction. We conclude that, in contrast to the SS-R, the DB-R has physiological characteristics (compliance yet contractility) that allow normal bowel habits, but only if it is placed in anatomical proximity to the anus.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Recombinant hemopoietic colony-stimulating factors (CSFs), including GM-CSF, G-CSF and IL-3, have been shown to be effective stimulators of both self-renewal and terminal differentiation of blast stem cells in acute myeloblastic leukemia (AML). We have examined the activity of a fourth growth factor, recombinant CSF-1 (or M-CSF), on the growth of leukemic blasts in culture. CSF-1 was found to be active on some, but not all, blast populations. In sensitive cells, CSF-1 often stimulated the production of adherent blast cells incapable of division. This observation leads us to suggest that CSF-1 may be useful in the treatment of selected cases of AML.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Myelopoietic growth factors are known to influence the growth in culture of malignant blast cells from human Acute Myeloblastic Leukemia (AML). We have used cDNA clones for the factor CSF-1 and its receptor fms to study DNA and RNA from the blasts of 25 AML patients. The CSF-1 gene was always in the germline configuration. CSF-1 mRNA was found in about half the blast populations. The cells were also studied for their growth properties in culture. A highly significant association was found between CSF-1 expression and poor growth in suspension culture. Most blast populations expressed fms; the number of fms expression negative samples was too small to permit the detection of any association between fms expression and growth or any interaction between the effects of the expression of the growth factor and its receptor. We propose that CSF-1 may be an important part of the mechanism determining the balance between self-renewal and determination in AML blast clones.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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