Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    A clinical and pharmacodynamic evaluation of sulpiride (1981)
    Springer
    Psychopharmacology 73 (1981), S. 77-80 
    Details
    ISSN: 1432-2072
    Keywords: Double-blind ; Sulpiride ; Haloperidol ; Chronic schizophrenia ; Drug concentration ; Prolactin level ; Clinical effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a double-blind study the therapeutic efficacy of sulpiride was compared to that of haloperidol — an established neuroleptic agent. A total of 30 female patients with a diagnosis of chronic schizophrenia were initially stabilised on the dosage of haloperidol which produced optimum therapeutic response when given once or twice daily. The patients were then randomly allocated to receive either sulpiride or haloperidol over a period of 12 weeks. Plasma drug concentrations and prolactin levels were determined. Clinical effects were evaluated by Brief Psychiatric Rating Scale (BPRS), Wing Rating Scale, and Extrapyramidal Symptoms Rating Scale (EPS). A standardised side-effects checklist was used. Treatment with sulpiride was associated with a significant rise in plasma prolactin level, but paradoxically these patients had significantly reduced extrapyramidal symptoms. No significant correlation was found between plasma sulpiride concentration and prolactin level or any of the clinical variables. The study confirms the antipsychotic activity of sulpiride.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431106
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A source of variance in IQ unique to the lower-scoring monozygotic (MZ) cotwin (1986)
    Springer
    Behavior genetics 16 (1986), S. 509-516 
    Details
    ISSN: 1573-3297
    Keywords: twins ; heritability ; environment ; intelligence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Environmental factors more common in twins than singletons appear to be disadvantageous with respect to intelligence. If these factors contribute to within-pair differences in IQ, the effect should be found more in the cotwin lower in IQ (the low twin) than in the cotwin higher in IQ (the high twin). In this case, the variance of the low twins should exceed that of the high twins. This hypothesis was tested for five samples of monozygotic (MZ) twins and three samples of dizygotic (DZ) twins but was confirmed only for the MZ samples. These results suggest that there are disadvantageous environmental factors unique to MZ twins which contribute to within-pair variability. Such factors will cause heritability coefficients obtained using MZ twins to be underestimated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066337
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Estimating true scores in kinship data (1987)
    Springer
    Behavior genetics 17 (1987), S. 487-491 
    Details
    ISSN: 1573-3297
    Keywords: true scores ; measurement error ; kinship data ; twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Estimated true scores are occasionally used to provide an estimate of scores which would be obtained if measurement error could be removed from fallible measures. When one knows only a test's relibility and an observed score for each subject, true scores are estimated by regressing observed scores toward the group mean. When relatives' observed scores are also available, estimates of true scores can be improved by using the additional information. Observed scores of subjects and relatives can be used as predictors of subjects' true scores in a multiple regression. The resulting formula is presented for the case in which only one relative's score per subject is known. Estimation of true scores for the general case ofN relatives per subject is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01073115
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...