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  • 1
    Electronic Resource
    Electronic Resource
    Structure of wye (Yt base) and wyosine (Yt) from Torulopsis utilis phenylalanine transfer ribonucleic acid (1976)
    s.l. : American Chemical Society
    Biochemistry 15 (1976), S. 898-904 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00649a027
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of interleukin 2 on basophil histamine release (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 42 (1987), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Accumulating evidence suggests a link between immediate hypersensitivity and cellular immunity. In this study, we examined the effect of interleukin 2 (IL-2) on basophil histamine release. Histamine-releasing activity of IL-2 was very weak with % histamine release of 2.9 ± 1.3 (mean ± SEM, n= 9) at 1:12 dilution. IL-2 at 1:1200 dilution slightly inhibited anti-IgE-induced histamine release by 22.4 ± 18.6% (P 〉 0.05). There was a significant potentiation of release at 1:12 dilution of IL-2 with % enhancement of 78.7 ± 42.2 (P 〈 0.05). IL-2 enhanced the calcium ionophore A23187-induced histamine release in a dose-dependent fashion. IL-2 at 1:12 dilution significantly potentiated release by 28.8 ± 6.3% (P 〈 0.05). There was a slight suppression of formyl-methionyl-leucyl-phenylalanine (FMLP)-induced histamine release at 1:1200 dilution with % inhibition of 23.4 ± 7 4 (P 〉 0.05). At 1:12 dilution, IL-2 significantly potentiated FMLP-induced release by 73.7 ± 41.6% (P 〈 0.05). Recombinant IL-2 (RIL-2) augmented anti-IgE-induced histamine release with a significant enhancement at 200 units/ml. Conventional IL-2 was more potent than RIL-2 in enhancing release. These results indicate that IL-2 enhances basophil histamine release and some part of the effect of IL-2 on basophils is derived from other factors contained in conventional IL-2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1987.tb02367.x
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  • 3
    Electronic Resource
    Electronic Resource
    Structure of 1-(1-naphthyl)-1H-1,2,3-triazole (1987)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 43 (1987), S. 147-149 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270187096689
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  • 4
    Electronic Resource
    Electronic Resource
    New layered structure of Bi2W2O9 determined by 1 MV high-resolution electron microscopy (1979)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 35 (1979), S. 142-145 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The crystal structure of bismuth tungstate, Bi2W2O9, has been examined by 1 MV high-resolution electron microscopy. The symmetry is orthorhombic with lattice parameters a = 5.43, b = 5.41 and c = 23.7 Å and space group Pna21. The point group is determined directly from the images in which each cation site is resolved. The structure is similar to that of conventional layered Bi compounds with respect to the Bi2O2 sheets normal to the c axis; however, the layer between the sheets is of a deformed ReO3 type. The strong chemical bonds between the Bi ions and the apex O atoms cause the rotation of the WO6 octahedron about the c axis. W ions are displaced antiparallel in the WO3 layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567739479000255
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  • 5
    Electronic Resource
    Electronic Resource
    Dislocations in solids. Vol 6. Applications and recent advances edited by F. R. N. Nabarro (1985)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 41 (1985), S. 623-623 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767385001416
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  • 6
    Electronic Resource
    Electronic Resource
    Structure of 1,8-bis(1'H-1',2',3'-triazolyl)napthalene (1986)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 42 (1986), S. 478-480 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270186095732
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  • 7
    Electronic Resource
    Electronic Resource
    Structure determination of a mixed-layer bismuth titanate, Bi7Ti4NbO21, by super-high-resolution electron microscopy (1977)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 33 (1977), S. 701-703 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The crystal structure of a bismuth titanate, Bi7Ti4NbO21, was determined on the basis of super-high- resolution images, taken by a recently constructed 1000 kV electron microscope, in which each cation site was approximately defined. It was found that the crystal has a mixed-layer structure, i.e. Bi4Ti3O12 and Bi3TiNbO9-like layers are alternately intergrown. The symmetry is orthorhombic with space group I2cm. The lattice parameters are a = 5.45, b = 5.42 and c = 58.1 Å. That the periodicity along c is twice that expected from a simple intergrowth can be accounted for by the rotation of octahedra. The lattice defects found are discussed in terms of twinning of the crystal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567739477001806
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  • 8
    Electronic Resource
    Electronic Resource
    Inhibitory effects of E-5110 on interleukin-1 generation from human monocytes (1989)
    Springer
    Inflammation research 27 (1989), S. 322-324 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of E-5110, a novel non-steroidal antiinflammatory drug, on interleukin-1 (IL-1) generation from human monocytes were studiedin vitro. E-5110 reduced the amounts of extra- and intracellular IL-1 activity induced by lipopolysaccharide (LPS, 1 μg/ml) in a dose-dependent manner (1–10μM). E-5110 also inhibited the IL-1 generation induced by antigen-antibody complexes, opsonized zymosan and silica particles. It was suggested that the inhibition of IL-1 generation by E-5110 was independent of the inhibitory effects on arachidonate cyclooxygenase and/or lipoxygenase because indomethacin, piroxicam, BW755C and AA861 had no effects on IL-1 generation. Hydrocortisone (IC50:0.084 μM), aurothioglucose (11.5 μM) and lobenzarit (75.0 μM), which are clinically effective antirheumatic drugs, also inhibited IL-1 generation, like E-5110 (1.21 μM). It is expected that E-5110 will be superior to classical non-steroidal antiinflammatory drugs in medical treatment of rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972811
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  • 9
    Electronic Resource
    Electronic Resource
    Ultrastructural immunocytochemistry of glia cells (1987)
    Springer
    Histochemistry and cell biology 87 (1987), S. 201-207 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The introduction of acrylate resins (Lowicryl K 4M, LR White) into electronmicroscopic immunocytochemistry applied to embedded tissue (post-embedding method) has improved the localization of antigens because of a satisfactory preservation of both ultrastructure and antigenicity of tissues. Here we describe a method that allows double staining of intracellular and membranous determinants in ultrathin sections of nervous tissue and cultures of peripheral nervous system cells. Ultrathin sections of the rat central nervous system fixed on uncoated grids were stained first for MBP selectively on the one face, then the opposite face was stained for GFAP using monoclonal antibodies and indirect immunogold staining method (IGS). Cultured Schwann cells induced to express major histocompatibility complex (MHC) class II antigens were stained for class. H antigens by pre-embedding method then followed by post-embedding IGS for the other intracytopasmic antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492410
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  • 10
    Electronic Resource
    Electronic Resource
    Plasma free fatty acids and protein binding of disopyramide during haemodialysis (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 327-329 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; protein binding ; intraindividual variability ; haemodialysis ; free fatty acids ; drug monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding of disopyramide (DSP) to plasma (or serum) proteins was determined using an ultrafiltration technique in three patients undergoing haemodialysis. An increase in the free fraction (FF) of DSP during dialysis occurred together with elevation of the free fatty acid (FFA) level in plasma. The effect of FFA on protein binding in vitro was examined using DSP- and FFA-spiked solutions containing human α1-acid glycoprotein and serum albumin. The FF of DSP rose in proportion to increasing FFA levels, supporting the in vivo observations. The findings suggest that the free concentration of DSP should be routinely monitored, especially in haemodialysis patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637572
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