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  • 1985-1989  (2)
  • 1975-1979  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of fenbufen in man (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 59-61 
    Details
    ISSN: 1432-1041
    Keywords: fenbufen ; antiinflammantory agents ; human pharmacokinetics ; metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of fenbufen (3.4-biphenylylcarbonyl propionic acid) a new antiinflammatory agent, and its metabolites, γ-hydroxy-4-biphenylbutyric acid and 4-biphenylacetic acid have been studied after oral administration to seven patients with rheumatoid arthritis. Fenbufen was administered as a single oral dose of 600 mg in hard gelatine capsules. A specific, sensitive gas chromatographic method was used to measure the concentration of the three compounds. A linear two-compartment open model appeared suitable to describe the course of the plasma level of fenbufen with time. This compound appeared in the blood after a lag time of 0.45 h and the peak plasma concentration of 5.97 µg/ml was observed after 1.19 h. The half-life of plasma disappearance was 10.26 h for fenbufen and 10.07 h and at 9.95 h for metabolites II and III, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644968
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The rheumatoid heel: Its relationship to other disorders in the rheumatoid foot (1989)
    Springer
    Clinical rheumatology 8 (1989), S. 208-214 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Foot ; Heel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fourhundred and eight rheumatoid feet are studied. The percentage of talalgia is 3.7%; for inferior exostosis it is 29.6%, and 30.8% for posterior exostosis. Posterior demineralisation is present in 12%, whereas for bony erosion it is 8.1%. Plantar spurs are very closely associated to flattened feet (p〈0.0001). Likewise a very noticeable statistical association is noted between postero-superior calcaneilis and tarsal arthritis (p〈0.0001), and calcaneitis was more frequent among marked valgus (p〈0.001). These results are compared with findings of other works. Therapeutic consequences are evoked.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030076
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Deformation of the adult rheumatoid rearfoot. A radiographic study (1987)
    Springer
    Clinical rheumatology 6 (1987), S. 539-544 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Foot ; Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three hundred ninety-seven adult rheumatoid feet were examined. Those in whom pain had been present since the onset of the disease were compared radiographically with the painless feet in standing position: examination of the talar angle and of the internal arch showed flattening on the affected feet. The calcaneal angle, on the other hand, showed no difference between the two groups, but this latter parameter is little affected by the valgus pronation deformity of the hindfoot most often seen in patients who had experienced foot pain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02330591
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    Paper (German National Licenses)
    Fulltext
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