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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of fenbufen in man (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 59-61 
    Details
    ISSN: 1432-1041
    Keywords: fenbufen ; antiinflammantory agents ; human pharmacokinetics ; metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of fenbufen (3.4-biphenylylcarbonyl propionic acid) a new antiinflammatory agent, and its metabolites, γ-hydroxy-4-biphenylbutyric acid and 4-biphenylacetic acid have been studied after oral administration to seven patients with rheumatoid arthritis. Fenbufen was administered as a single oral dose of 600 mg in hard gelatine capsules. A specific, sensitive gas chromatographic method was used to measure the concentration of the three compounds. A linear two-compartment open model appeared suitable to describe the course of the plasma level of fenbufen with time. This compound appeared in the blood after a lag time of 0.45 h and the peak plasma concentration of 5.97 µg/ml was observed after 1.19 h. The half-life of plasma disappearance was 10.26 h for fenbufen and 10.07 h and at 9.95 h for metabolites II and III, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644968
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chronopharmacokinetic study of a prolonged release form of indomethacin (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 667-670 
    Details
    ISSN: 1432-1041
    Keywords: indomethacin ; prolonged release form ; chrono-pharmacokinetics ; nocturnal dosing ; rheumatoid diseases ; reduced side-effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The chronopharmacokinetics of indomethacin was studied in patients with rheumatoid diseases after a single oral dose of a new prolonged-release form containing indomethacin 75 mg. The drug was given either at 8, 12 or 20 h and its plasma concentrations, as well as those of its main metabolite, O-desmethyl indomethacin, were followed using a new specific gas chromatographic assay. When given at 20 h plasma indomethacin concentrations did not exhibit a sharp peak and remained much more stable than when the drug was given at 8 or 12 h. In addition, plasma O-desmethyl indomethacin was significantly higher after administration of indomethacin at 20 h than at 8 or 12 h. It is concluded that the pharmacokinetics of the oral prolonged-release form of indomethacin exhibited chronobiological variation. The data are in accordance with clinical studies which suggest that it might be worthwhile to administer this formulation of indomethacin at 20 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542219
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Deformation of the adult rheumatoid rearfoot. A radiographic study (1987)
    Springer
    Clinical rheumatology 6 (1987), S. 539-544 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Foot ; Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three hundred ninety-seven adult rheumatoid feet were examined. Those in whom pain had been present since the onset of the disease were compared radiographically with the painless feet in standing position: examination of the talar angle and of the internal arch showed flattening on the affected feet. The calcaneal angle, on the other hand, showed no difference between the two groups, but this latter parameter is little affected by the valgus pronation deformity of the hindfoot most often seen in patients who had experienced foot pain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02330591
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The rheumatoid heel: Its relationship to other disorders in the rheumatoid foot (1989)
    Springer
    Clinical rheumatology 8 (1989), S. 208-214 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Foot ; Heel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fourhundred and eight rheumatoid feet are studied. The percentage of talalgia is 3.7%; for inferior exostosis it is 29.6%, and 30.8% for posterior exostosis. Posterior demineralisation is present in 12%, whereas for bony erosion it is 8.1%. Plantar spurs are very closely associated to flattened feet (p〈0.0001). Likewise a very noticeable statistical association is noted between postero-superior calcaneilis and tarsal arthritis (p〈0.0001), and calcaneitis was more frequent among marked valgus (p〈0.001). These results are compared with findings of other works. Therapeutic consequences are evoked.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030076
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Schwierigkeiten der Diagnose beruflicher Vergiftungen für den praktischen Arzt (1934)
    Springer
    International archives of occupational and environmental health 5 (1934), S. 274-285 
    Details
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Schluβ Eine rapid vorwärtsschreitende Technik hat die Lebensbedingungen unserer Generation tiefgreifendst umgestaltet und auch früher ungeahnte Gefahren für die Gesundheit unseres Volkes mit sich gebracht. Diese in ihren mannigfaltigen und stets wechselnden Formen zu erkennen und abzuwehren, ist eine der dringendsten Aufgaben, die die Gegenwart der Ärzteschaft stellt. Hier ein Weniges mitzuhelfen und aus der beschränkten Erfahrung einer Landarztpraxis auf die speziell den praktischen Arzt bedrängenden Unvollkommenheiten unseres Wissens und Denkens hinzuweisen, betrachtete ich als die Aufgabe dieser Arbeit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02122940
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Immunoelectrophoretic investigations in 55 patients with systemic amyloidosis (1984)
    Springer
    Annals of hematology 49 (1984), S. 91-94 
    Details
    ISSN: 1432-0584
    Keywords: Amyloidosis ; Monoclonal protein ; Immunoglobulins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among 55 amyloidoses, the detection of a monoclonal protein (MP) led to the selection of 15 primary and 3 myeloma-associated types of amyloidosis. Therefore the presence of a MP gives evidence for an immunocytic amyloidosis. The λ-light-chain nature of MP and the abundant production of free light-chains are two of the factors predisposing to the production of amyloid deposits (AL) in the course of immunocyte dyscrasias.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363699
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    Paper (German National Licenses)
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