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  • 1985-1989  (2)
  • 1970-1974
  • 1900-1904
  • Blood-brain barrier  (1)
  • CSF-Cytologie  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Complement-derived polypeptide C3adesArg as a mediator of inflammation at the blood-brain barrier in a new experimental cat model (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 307-313 
    Details
    ISSN: 1432-0533
    Keywords: Complement system ; Inflammation ; Blood-brain barrier ; Meningitis ; Cat model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the complement-derived polypeptide C3adesArg as a mediator of inflammation in the central nervous system was examined. Twenty-five anesthetized cats received 4 mg of this polypeptide by intraventricular injection, 20 cats who served as controls received saline. Cerebrospinal fluid (CSF) was sampled 3 h after intraventricular injection and the brains were removed. For assessment of the permeability of the blood-brain barrier the CSF penetration of four antibiotics, which were given intravenously, was measured. Five control animals were employed for each antibiotic (tobramycin, ampicillin, imipenem, fosfomycin), whereas six C3adesArg-treated animals were used for each antibiotic and seven for tobramycin. Besides CSF levels of glucose, the prostanoids 6-keto-prostaglandin F1α, thromboxane B2 and prostaglandin E2 were measured. The morphological examinations in the CSF sediments and histological brain sections in the C3adesArg-treated animals disclosed a distinct inflammation with leptomeningeal and perivascular infiltration of polymorphonuclear granulocytes compared to normal findings in the controls. The CSF/serum ratios of all of the antibiotics were markedly elevated compared to controls, indicating a blood-brain barrier disruption. The levels of all prostanoids were significantly higher in the treatment group than in the control group, whereas the glucose levels were lower. These findings are in accordance with a granulocytic meningitis as seen in some infections at the acute stage. It is concluded that C3adesArg acts as a mediator of inflammation in the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687583
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Fatale eosinophile meningoencephalitis nach lackintoxikation (1986)
    Springer
    European archives of psychiatry and clinical neuroscience 235 (1986), S. 378-381 
    Details
    ISSN: 1433-8491
    Keywords: Eosinophilic meningoencephalitis ; CSF-cytology ; Helminthic infections ; Allergic-toxic encephalitis ; Eosinophile Meningoencephalitis ; CSF-Cytologie ; Wurmerkrankungen ; Allergisch-toxische Enzephalitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Berichtet wird über eine akute toxische Schädigung des Gehirns bei einem 43-jährigen Patienten, der 12 Tage vor seinem Tode, nach dem Versiegeln seines Bodens an starken Kopfschmerzen ohne Fieber erkrankte und eine extreme Eosinophilie im Liquor cerebrospinalis zeigte. Eine Übersicht über die mannigfaltige Ätiologie der Liquoreosinophilie wird gegeben.
    Notes: Summary The authors report about a 43-year-old male patient, who suffered from an acute toxic brain injury. Twelve days prior to death, after sealing his floor, he experienced progressively increasing headache without fever; the CSF examination disclosed marked eosinophilia. The clinical and pathomorphological features of his illness are discussed and together with the various possible etiologies of eosinophilia in the CSF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381008
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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