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  • 1985-1989  (2)
  • 1970-1974
  • Bis-β-diketonato metal complexes of titanium, zirconium, and hafnium  (1)
  • MNU  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Efficacy of β-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 446-450 
    Details
    ISSN: 1432-1335
    Keywords: Bis-β-diketonato metal complexes of titanium, zirconium, and hafnium ; Budotitane ; Acetoxymethylmethylnitrosamine-induced autochthonous colorectal tumors ; Antitumor activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bis-β-diketonato complexes of titanium, zirconium, and hafnium were tested against autochthonous colorectal tumors in rats. The model was found to reflect the clinical situation most closely. of the compounds tested, budotitane was the most effective in terms of decrease in tumor weight and number and in increasing the lifespan of the treated animals. The therapeutic efficiency was superior to that of 5-fluorouracil, which so far has been the drug with the best activity in patients suffering from colon cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390038
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Therapeutic ratio of mono or combination bacterial lipopolysaccharide therapy in methylnitrosourea — induced rat mammary carcinoma (1987)
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 437-445 
    Details
    ISSN: 1432-1335
    Keywords: MNU ; induced mammary carcinoma ; Bacterial lipopolysaccharide ; Mono and combination therapy ; toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four experiments investigating the antitumor activity of bacterial lipopolysaccharide (LPS) against the autochthonous methylnitrosourea — induced mammary carcinoma are summarized. Administration of LPS alone i.v. caused distinct regression of small tumors following its first injection. This therapeutic effect, however, was short-lived and could not be maintained by administering a second dose. The observed antineoplastic activity of LPS was dose-related, whereas no dose-response relationship was observed with respect to its toxicity. A series of experiments in which LPS was combined with other compounds to possibly exploit its activity while reducing the toxicity were performed. Neither the combination with cytotoxic drugs such as 4′-(9-acridinylamino.)-methansulfone-m-aniside or cyclophosphamide nor that will 1-octadecyl-2-methoxy-rac-glycero-3-phosphocholine or hexadecylphosphocholine showed sufficient anticancer activity at acceptable toxicity. In all experiments promising efficacy was observed at high dosages but also high toxicity. When the dosages were reduced, diminished antineoplastic activity was found together with overproportionally high mortality. It might therefore be concluded that the active dose range of LPS cannot be reached clinically because of its inherent toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390037
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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