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  • 1985-1989  (2)
  • 1970-1974
  • Monoamine oxidase  (1)
  • Parkinson's disease  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil (1987)
    Springer
    Journal of neural transmission 70 (1987), S. 369-376 
    Details
    ISSN: 1435-1463
    Keywords: Monoamine oxidase ; locus coeruleus ; histochemistry ; Mongolian gerbil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A coupled peroxidation technique for localization of monoamine oxidase (MAO-A and MAO-B), applied to post-mortem fixed tissue of the locus coeruleus of the Mongolian gerbil is demonstrated. Tyramine hydrochloride,Β-phenylethylamine and 5-hydroxytryptamine creatinine sulphate were used as substrates, l-deprenyl and clorgyline served as specific inhibitors. All three substrates stained the neurons of locus coeruleus in the absence of inhibitor. In the presence of 1-deprenyl, tyramine hydrochloride and 5-hydroxytryptamine creatinine sulphate were metabolized, whereas in the presence of clorgyline no reaction with either substrate could be observed. Immunocytochemical staining of tyrosine hydroxylase (TH) was employed as comparison.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253611
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Homospecific activity (activity per enzyme protein) of tyrosine hydroxylase increases in parkinsonian brain (1988)
    Springer
    Journal of neural transmission 72 (1988), S. 77-82 
    Details
    ISSN: 1435-1463
    Keywords: Parkinson's disease ; tyrosine hydroxylase ; homospecific activity ; compensatory mechanisms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tyrosine hydroxylase (TH) contents in the caudate nucleus, putamen, and substantia nigra from control and parkinsonism brains were measured for the first time by a sandwich enzyme immunoassay. Both the TH protein content and TH activity (Vmax) were decreased in parallel in the parkinsonian brains as compared with those of the control brains. In contrast, TH “homospecific activity” (activity per enzyme protein) was significantly increased in the parkinsonian brains. The results indicate that the decrease of TH activity in parkinsonian brains is due to the decrease of TH protein content as a result of cell death. The increase in the “homospecific activity” of residual TH in parkinsonian brain suggests such molecular changes in TH molecules as result in a compensatory increase in TH activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244634
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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