ISSN:
1432-1041
Keywords:
Hypertension
;
chlorthalidone
;
pindolol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The antihypertensive effect of a new beta-blocking agent, pindolol, has been compared with that of chlorthalidone (Hygroton) in a double-blind-cross-over-trial using fixed doses twice a day. 35 men, aged 40–59 years, were studied, 21 with grade I hypertension and 14 with grade II (WHO classification). — At rest, no difference was found between the two drugs in their effect of lowering the blood pressure. During exercise, pindolol decreased the systolic blood pressure more than chlorthalidone; no differences were found in the diastolic blood pressures. The blood pressure lowering effects after exercise were also the same. — The heart rate was significantly slowed by pindolol at rest and during and after exercise, whereas chlorthalidone caused an increased rate at rest but not during exercise. The pulse pressure product was decreased at rest, and during and after exercise on treatment with pindolol. It was not changed significantly at rest during chlorthalidone treatment, but fell during exercise, although not to the same extent as during pindolol treatment. — None of the drugs caused any serious side effects. No major differences were found in side effects or patient preferences. — It is concluded that both drugs are useful antihypertensive agents. At present there is no reason to prefer one or the other for general use.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00567005
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