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  • 1
    Electronic Resource
    Electronic Resource
    Signals from the future (1972)
    Springer
    International journal of theoretical physics 6 (1972), S. 377-382 
    Details
    ISSN: 1572-9575
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Advanced interactions do not lead to dynamical inconsistencies in closed systems. They are, however, incompatible with the existence of truly random processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01258732
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A voltage-dependent K+ channel controlling the membrane potential in frog oocytes (1985)
    Springer
    Pflügers Archiv 403 (1985), S. 41-46 
    Details
    ISSN: 1432-2013
    Keywords: Rana esculenta ; Ovarian oocytes ; Potassium channels ; Membrane potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Full-grown frog ovarian oocytes (Rana esculenta), were voltage clamped with a conventional two-microelectrode system. Depolarizations from a holding potential of −60 mV produced slowly developing outward currents. Two-step clamp experiments showed that, in Ringer's solution, this current has a reversal potential at about −84 mV. Substitution of either sodium or chloride with impermeant ions in the external solution did not alter significantly the activation of the current nor its reversal potential. Increasing the potassium ions concentration caused a shift on the reversal potential in the positive direction with a slope of about 48 mV per decade. The presence of TEA ions (50 mM) in the external solution partially reduced the current. It is concluded that the membrane of full-grown frog ovarian oocytes possesses voltage-dependent ionic channels permeated mainly by potassium. They appear to play an important role in the control of membrane potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583279
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A voltage-dependent calcium current in mouse Swiss 3T3 fibroblasts (1988)
    Springer
    Pflügers Archiv 411 (1988), S. 554-557 
    Details
    ISSN: 1432-2013
    Keywords: Fibroblast ; Ca2+ current ; Whole-cell patchclamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patch-clamp experimens in the whole-cell mode have been performed in Swiss 3T3 mouse fibroblasts. Depolarizations from negative holding potential (V h〈−60mV) gave rise to a rapidly activating, fully inactivating, inward current of few tenths of nA in physiological saline at 35°C. The current persisted when external Na+ was replaced by impermeant TMA+ and disappeared in O Ca2+, 1 mM EGTA. The current was reversible blocked by Co2+ and it was slightly reduced when external Ca2+ was substituted by Ba2+. Finally its reversal potential changed with Nernstian slope with increasing external Ca2+ concentrations. It is concluded that these cells possess a voltagedependent Ca2+ channel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582377
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Computer reconstruction of the spread of excitation in nerve terminals with inhomogeneous channel distribution (1986)
    Springer
    European biophysics journal 13 (1986), S. 235-243 
    Details
    ISSN: 1432-1017
    Keywords: Nerve endings ; action potential ; computer simulation ; membrane heterogeneity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract A direct numerical integration method, as modified by Du Fort and Frankel (1953), has been used to solve the partial differential equation system which describes the spread of action potential in a mammalian nerve terminal. Branching of the terminal as well as inhomogeneous distributions of Na+ and K+ voltage-dependent channels (Brigant and Mallart 1982) have been incorporated in the model. Using the channel densities and the kinetic parameters measured in the node of Ranvier, the depolarization in the terminal branches has an amplitude of only 60% of the action potential in the node. Furthermore, the time courses of the calculated membrane currents differ considerably from the ones measured by Brigant and Mallart (1982) and by Konishi and Sears (1984). Increasing the Na+ and K+ channel densities may considerably increase the terminal depolarization and also reproduce qualitatively the current waveforms observed experimentally. The model can also reproduce some of the effects of pharmacological channel blocks. The simulation allows a new interpretation of the different components of membrane current along the terminal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00260370
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    Paper (German National Licenses)
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