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  • 1985-1989  (1)
  • 1965-1969  (1)
  • Catecholamines  (1)
  • MCA  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Mucin-like cancer-associated antigen (MCA) compared with CA 15-3 in advanced breast cancer (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 813-817 
    Details
    ISSN: 1432-1440
    Keywords: Tumor marker ; MCA ; CA 15-3 ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mucin-like cancer-associated antigen (MCA), a new tumor marker using the mouse monoclonal antibody b-12 is thought to be of value in the management of patients with breast cancer. In this study sera from 191 female patients with breast cancer (112 with progressive disease [PD] and 79 with no evidence of disease [NED]) were analyzed for MCA levels and compared with those of cancer antigen 15-3 (CA 15-3) in single determination and in combination with carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA). A cut-off level of 14 U/ml for MCA seems to be more appropriate than the recommended 11 U/ml to distinguish between PD and NED in patients with breast cancer. Although there was a fairly good correlation of MCA to CA 15-3, MCA was inferior in sensitivity and specificity to CA 15-3. Patients with osseous metastases and those with more than one metastatic site showed higher MCA levels than patients with visceral or soft tissue metastases, a fact which was comparable to CA 15-3. Combining MCA and CA 15-3 resulted in a gain in specificity but marked loss of sensitivity. The combination of MCA and CEA results also in a loss of sensitivity whereas the combination of CA 15-3 and CEA showed an increased specificity and only a negligible loss of sensitivity. The combination of MCA with TPA is of little value in the follow-up of breast cancer, as is the combination of CA 15-3 with TPA. The combination of CA 15-3 with CEA can be still recommended for follow-up for early detection of metastases in breast cancer. Further investigations with MCA to determine the lead time of this new marker as well as its role as a possible monitor of the response to therapy are recommended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725197
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Beeinflussung des Myokardstoffwechsels durch Oxyfedrin (1969)
    Springer
    Clinical and experimental medicine 151 (1969), S. 163-174 
    Details
    ISSN: 1591-9528
    Keywords: Myocardial metabolism ; Oxyfedrin ; Catecholamines ; Myokardstoffwechsel ; Oxyfedrin ; Katecholamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß von Oxyfedrininfusionen auf die arteriellen Konzentrationen von Glucose, Lactat, Pyruvat, Freien Fettsäuren, Acetacetat, 3-Hydroxybutyrat, Neutralfetten und Glycerin sowie die Aufnahme dieser Substrate in das Myokard wurde an Hunden mittels Sinus coronarius-Katheterisierung untersucht. Während die Freien Fettsäuren und die Ketonkörper einen starken arteriellen Anstieg sowie auch eine vermehrte Extraktion durch das Myokard zeigten, kam es zu einem arteriellen Abfall und verminderter myokardialer Aufnahme von Lactat und Pyruvat. Die unterschiedliche Wirkung von Oxyfedrin und Katecholaminen auf den Myokardstoffwechsel wird diskutiert.
    Notes: Summary The influence of Oxyfedrin on the arterial levels and the myocardial extraction of glucose, lactate, pyruvate, free fatty acids, acetoacetate, 3-hydroxybutyrate, esterified fatty acids and glycerol has been studied by coronary sinus catheterization on dogs. The arterial levels and myocardial extraction of free fatty acids and ketone-bodies were markedly increased, the arterial concentration and myocardial uptake of pyruvate and lactate were found to be decreased. The different effect of Oxyfedrin and catecholamines on myocardial metabolism has been discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02044669
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    Paper (German National Licenses)
    Fulltext
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