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  • 1985-1989  (2)
  • 1960-1964
  • D-2 agonist  (1)
  • Lauren classification  (1)
  • 1
    ISSN: 1420-9071
    Keywords: CQP 201-403 ; 8α-amino-ergolines ; ergot pharmacology ; D-2 agonist ; endocrine ; CNS ; cardiovascular actions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-2451
    Keywords: Stomach Cancer ; Lauren classification ; Prognosis ; Recurrence ; Magencarcinom ; Lauren-Klassifikation ; Prognose ; Rezidiv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Beim Intestinalzelltyp unterscheidet sich die Rezidivrate bei einem Sicherheitsabstand von unter 20 mm (20,5%) nicht von einer Distanz über 20 mm (13,0%). Beim diffusen Typ kann eine Vergrösserung des Abstandes auf über 40 mm, die Rate von 26,5 auf 15,8% senken (n = 700, 1969–1985/31.12.86, RO). Bei Beachtung der Abstände nach oral und aboral beträgt für beide Typen die Rate eines lokalen Rezidivs 10%, die Prognose ist identisch (5-Jahresüberlebensrate bei diffusem/Intestinalzelltyp, pathologisches Stadium I 84,7/69,2%, II 62,6/65,9%, III 36,2/34,7%). Die Sicherheitsabstände sind besonders wichtig im Bereich von Oesophagus und Duodenum.
    Notes: Summary For the intestinal cell type of stomach cancer according to Lauren's classification, the local recurrence rate does not vary with a safety margin above or below 20 mm. However, enlargement over 40 mm can reduce the rate of local recurrence from 26.5% to 15.8% for the diffuse type (n = 700). With respect to the safety margin in oral and aboral resection lines, the rate is the same for both types (10%) as is the prognosis.
    Type of Medium: Electronic Resource
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