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Heterogeneous malignant non Hodgkin's lymphomas as a causative disorder in lethal midline granuloma (1989)

Laeng, R. Hubert ; Gerber, Heinz A. ; Schaffner, Thomas ; [et al.]

Springer

Virchows Archiv 415 (1989), S. 265-273

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ISSN: 1432-2307

Keywords: Midline granuloma ; Histochemistry ; B cell NHL ; T cell NHL ; Malignant histiocytosis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The present report describes the results of a combined morphological, enzyme- and immunohistochemical analysis of nine cases of malignant non Hodgkin's lymphomas (NHL) clinically presenting as lethal midline granuloma. In a previous report written before antibodies directed against B and T lymphocytes were available, a histiocytic origin of such neoplasms had been suggested. A panel of antibodies reactive with most B cells (L26, MB1, KiB3) and a majority of T cells (MT1, UCHL1) was applied on paraffin sections of formalin fixed tissues as well as antibodies directed against leukocyte common antigen (LCA), myeloid/histiocyte antigen (MAC 387), lysozyme, alpha-1-antitrypsin, alpha-1-antichymotrypsin, S-100 protein, prekeratin and immunoglobulin light chains. Enzyme histochemistry included tests for non-specific acid esterase, acid phosphatase, betaglucuronidase and chloroacetate esterase. As a result, five T, two B and two unclassified (malignant histiocytosis probable) NHL were identified, indicating distinct heterogeneity of NHL as causative disorders in lethal midline granuloma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00724914

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Application of 1H/13C inversely correlated NMR spectroscopy to the determination of the stereochemistry of a polysubstituted [2.2]paracyclophane (1988)

Fischer, Rüdiger E. ; Dabrowski, Janusz ; Ejchart, Andrzej ; [et al.]

Chichester : Wiley-Blackwell

Organic Magnetic Resonance 26 (1988), S. 834-838

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ISSN: 0749-1581

Keywords: 4,7-Dichloro-5,8,12,15-tetramethoxy-13,16-bis[4-(2-methoxycarbonylphenyl) butyl][2.2]paracyclophane ; Stereochemistry ; 1H/13C inversely correlated NMR ; Bridge proton coupling constants ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The relative orientation of substituents in the opposite rings of one of the isomeric 4,7-Dichloro-5,8,12,15-tetramethoxy-13,6-bis[4-(2-methoxycarbonylphenyl) butyl][2.2]paracyclophanes was determined by establishing by NOE their orientation relative to the bridge protons, which thus served as ‘space-spy nuclei’. The mutual orientation of these bridge protons was ascertained by the analysis of their coupling constants, obtained from a phasesensitive COSY spectrum. The 1H and 13C resonances were assigned with the aid of 1H COSY and 1H/13C inversely correlated spectra.

Additional Material: 4 Ill.