ISSN:
1432-069X
Keywords:
New Zealand mice
;
MRL mice
;
BXSB mice
;
Lupus-band test
;
Anti-ssDNA antibodies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The skin of New Zealand, MRL and BXSB mice was immunohistopathologically examined in order to study the appearance of skin immunologublin (Ig) deposition and its correlation with the occurrence of anti-single-stranded (ss) DNA antibodies in sera. Our studies revealed Ig deposition at the dermoepidermal junction (DEJ) in non-lesional skin and a significant age-related correlation between skin Ig deposition and serum anti-ssDNA antibodies. However, immunofluorescent study of autoimmune mice using anti-ultraviolet-irradiated DNA antiserum failed to demonstrate DNA antigens at the DEJ.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00414101
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