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  • 1
    Electronic Resource
    Electronic Resource
    Dermatopathological studies on skin lesions of MRL mice (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 186-194 
    Details
    ISSN: 1432-069X
    Keywords: MRL/l mouse ; New Zealand mouse ; Lupus band test ; Anti-DNA antibodies ; Proteinuria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The MRL-lpr/lpr(MRL/l) mouse is a new animal model for human systemic lupus erythematosus (SLE) and skin lesions with hair loss and scab formation are one of the characteristic manifestations in this mouse. We investigated the histopathology of the skin lesions in MRL/l mice and studied the related autoimmune phenomenon. Light microscopical observations revealed hyperkeratosis, acanthosis, hypergranulosis, liquefaction, vasodilation in the dermis and T-cell infiltration into the dermis at the age of 5 months (mo). Immunohistological studies showed the presence of immunoglobulins and/or complement depositions at the dermal-epidermal junction (DEJ). In some mice there was deposition of immunoglobulin at the DEJ at 2 mo and in 90%–100% of MRL/l mice at over 5 mo. Temporal relationship was present among cutaneous immunoglobulin depositions, the occurrence of anti-DNA antibodies and proteinuria. These findings suggest that MRL/l mice might provide a new aid for studying the biological mechanisms of the development of skin lesions in human SLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414018
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  • 2
    Electronic Resource
    Electronic Resource
    Anti-hapten antibodies and autoantibodies in Japanese patients with lepromatous leprosy (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 195-198 
    Details
    ISSN: 1432-069X
    Keywords: Lepromatous leprosy ; Anti-hapten antibody ; Polyclonal B-cell activation ; Circulating immune complexes ; antinuclear antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the sera of patients with lepromatous leprosy anti-DNP antibodies were detected in order to determine the mode of ployclonal B-cell activation. Anti-DNP antibodies were found in 30% of the patients with active lepromatous leprosy and in 8% of those with inactive lepromatous leprosy. The level of anti-DNP antibodies in active patients was significantly higher than the level in inactive patients and control. However, the presence of anti-DNP antibodies was unrelated to the production of circulating immune complexes and antinuclear antibodies. These results suggest that polyclonal B-cell activation might occur but that the B-cell clones stimulated by M. leprae are different from patient to patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414019
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural observations of skin lesions in MRL mice —dermoepidermal junction (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 229-234 
    Details
    ISSN: 1432-069X
    Keywords: MRL mouse ; Dermoepidermal junction ; Ultrastructural changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The MRL-lpr/lpr (MRL/1) mouse, a new animal model for the study of human systemic lupus erythematosus (SLE), shows characteristic skin manifestations in addition to several systemic autoimmune phenomena. The ultrastructural changes observed in the dermoepidermal junction (DEJ) and in the uppermost dermis were: (1) infolding of the DEJ; (2) deformities of the basal lamina, — partial disappearance, thickening, hanging down, duplication, and separation from the basal cell membrane; (3) basal laminalike dense material in the uppermost dermis and increased anchoring fibrils; (4) particles composed of circulated half-desmosomes between the basal cells and the basal lamina, and in the uppermost dermis with or without an enclosing basal lamina; (5) cell processes of the basal cells; and (6) invagination of the basal lamina in the basal cells. Most of these findings were similar to the ultrastructural changes observed in the skin lesions of human SLE. The skin eruptions of MRL/l mice might be a new aid in the investigation of the pathogenesis of the skin lesions of human SLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414233
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of single-stranded DNA on circulating immune complexes in SLE sera detected by C1q solid-phase assay (1984)
    Springer
    Archives of dermatological research 277 (1984), S. 71-74 
    Details
    ISSN: 1432-069X
    Keywords: Circulating immune complexes ; Systemic lupus erythematosus ; Single-stranded DNA ; Inhibition assay ; C1q solid-phase assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406484
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  • 5
    Electronic Resource
    Electronic Resource
    Pathogenesis of lupus dermatoses in autoimmune mice (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 79-83 
    Details
    ISSN: 1432-069X
    Keywords: New Zealand mice ; MRL mice ; BXSB mice ; Lupus-band test ; Anti-ssDNA antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The skin of New Zealand, MRL and BXSB mice was immunohistopathologically examined in order to study the appearance of skin immunologublin (Ig) deposition and its correlation with the occurrence of anti-single-stranded (ss) DNA antibodies in sera. Our studies revealed Ig deposition at the dermoepidermal junction (DEJ) in non-lesional skin and a significant age-related correlation between skin Ig deposition and serum anti-ssDNA antibodies. However, immunofluorescent study of autoimmune mice using anti-ultraviolet-irradiated DNA antiserum failed to demonstrate DNA antigens at the DEJ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414101
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of colchicine and cytochalasin B on distribution of concanavalin A receptors in isolated and cultured guinea pig epidermal cells (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 392-397 
    Details
    ISSN: 1432-069X
    Keywords: Colchicine ; Concanavalin A receptors ; Cytochalasin B ; Epidermal cells, isolated and cultured
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Regulation of the distribution of concanavalin A (Con A)/receptor complexes by the cytoskeletal contracture system was studied in guinea pig epidermal cells in suspension and culture using the fluorescence double staining method. After treatment with 100 μg/ml of Con A at 37°C for 30 min lectin/receptor complexes were endocytosed by the less-differentiated cells in suspension and by the adherent cells in 1- and 3-day cultures that represent a growing cell fraction. The same treatment resulted in diffuse surface distribution of the complexes in the well-differentiated cells in suspension. Colchicine (10-3 and 10-6 M) inhibited internalization of the complexes with resultant diffuse distribution in 60% of the adherent cells in culture. Cytochalasin B (5 and 10 μg/ml) not only inhibited endocytosis but promoted formation of surface patchy clumps of the complexes in suspended, less-differentiated cells and cultured adherent cells. The distribution profile was not influenced by these drug treatments in the well-differentiated cells. SDS polyacrylamide gel electrophoresis and autoradiography of 125I-labelled epidermal membranes revealed several Con A-reactive polypeptides common to the cells at various differentiation steps. The progressive decrease in endocytosis and mobility of Con A/receptor complexes was suggested to occur with differentiation. In the germinative cells the distribution of lectin/receptor complexes seemed to be regulated by microfilaments and microtubules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412625
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  • 7
    Electronic Resource
    Electronic Resource
    Possible polyclonal B cell activation in mucocutaneous lymph node syndrome (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 104-108 
    Details
    ISSN: 1432-1076
    Keywords: Mucocutaneous lymph node syndrome ; Polyclonal B cell activation ; Anti-DNP antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunoserological studies on polyclonal B cell activation were carried out on 39 patients with mucocutaneous lymph node syndrome (MCLS) and in age-matched healthy individuals. The incidence of anti-mite, P. acnes (Kato) and EB virus antibodies, recently proposed as aetiological agents by some investigators, was increased in the patient group. Serum immunoglobulin (Ig) M level and IgM-anti-dinitrophenyl (DNP) antibodies, which are considered to be parameters of polyclonal B cell activation, were determined in MCLS cases. The level of serum IgM in MCLS was significantly elevated (0.02〈P〈0.05). Levels of anti-DNP antibodies in seven cases of MCLS (18%) were significantly higher than those of the controls (P〈0.01). Nine of the ten pair sera in MCLS showed a stage-dependent decrease in anti-DNP antibodies. These results suggest that polyclonal B cell activation occurs in MCLS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441867
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  • 8
    Electronic Resource
    Electronic Resource
    An immunohistochemical study of intracranial germ cell tumours (1987)
    Springer
    Acta neurochirurgica 86 (1987), S. 33-41 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial germ cell tumour ; alpha fetoprotein ; human chorionic gonadotropin ; glial fibrillary acidic protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histologically verified intracranial tumours, mainly germ cell tumours of the pineal and suprasellar regions, were studied immunohistochemically using anti-serum of alpha fetoprotein (AFP), human chorionic gonadotropin (HCG), carcinoembryonic antigen (CEA), human placental lactogen (HPL), pregnancy specific β-1 glycoprotein (SP-1), glial fibrillary acidic protein (GFAP), S-100 and neuron specific enolase (NSE). In germinomas, HCG positive cells were occasionally demonstrated in cells presenting as syncytiotrophoblastic giant cells (STGC), and GFAP and S-100 positive cells were found in the surrounding gliotic lesions. Teratomas were positive for CEA in their epithelial components. Endodermal sinus tumours were positive for AFP, choriocarcinomas for HCG and SP-1, and embryonal carcinomas for AFP, HCG and SP-1. HCG and SP-1 positive cells were demonstrated in STGC. As for the relationship between serum AFP level and tissue localization, many cases presenting a serum AFP level exceeding 220 ng/ml were positive for AFP in tumour tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419502
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  • 9
    Electronic Resource
    Electronic Resource
    Phase Boundary Migration Due to Interdiffusion (1996)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 204-206 (Mar. 1996), p. 215-220 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/01/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.204-206.215.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    E- and P-cadherin expression during murine hair follicle morphogenesis and cycling (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 8 (1999), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of adhesion molecules in the control of hair follicle (HF) morphogenesis, regression and cycling is still rather enigmatic. Since the adhesion molecules E- and P-cadherin (Ecad and Pcad) are functionally important, e.g. during embryonic pattern formation, we have studied their expression patterns during neonatal HF morphogenesis and cycling in C57/BL6 mice by immunohistology and semi-quantitative RT-PCR. The expression of both cadherins was strikingly hair cycle-dependent and restricted to distinct anatomical HF compartments. During HF morphogenesis, hair bud keratinocytes displayed strong Ecad and Pcad immunoreactivity (IR). While neonatal epidermis showed Ecad IR in all epidermal layers, Pcad IR was restricted to the basal layer. During later stages of HF morphogenesis and during anagen IV-VI of the adolescent murine hair cycle, the outer root sheath showed strong E- and Pcad IR. Instead, the outermost portion of the hair matrix and the inner root sheath displayed isolated Ecad IR, while the innermost portion of the hair matrix exhibited isolated Pcad IR. During telogen, all epidermal and follicular keratinocytes showed strong Ecad IR. This is in contrast to Pcad, whose IR was stringently restricted to matrix and secondary hair germ keratinocytes which are in closest proximity to the dermal papilla. These findings suggest that isolated or combined E- and/or Pcad expression is involved in follicular pattern formation by segregating HF keratinocytes into functionally distinct subpopulations; most notably, isolated Pcad expression may segregate those hair matrix keratinocytes into one functional epithelial tissue unit, which is particularly susceptible to growth control by dermal papilla-derived morphogens. The next challenge is to define which secreted agents implicated in hair growth control modulate these follicular cadherin expression patterns, and to define how these basic parameters of HF topobiology are altered during common hair growth disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1999.tb00377.x
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