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  • 1985-1989  (5)
  • 1935-1939
  • Organic Chemistry  (4)
  • Interstitielles Lungenödem  (1)
  • 1
    Electronic Resource
    Electronic Resource
    378. Kinine-Mediatoren der akuten respiratorischen Insuffizienz bei der akuten nekrotisierenden Pankreatitis (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 873-873 
    Details
    ISSN: 1435-2451
    Keywords: Kinins ; Interstitial lung edema ; Acute necrotizing pancreatitis ; Kinine ; Interstitielles Lungenödem ; Akute nekrotisierende Pankreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Während der akuten nekrotisierenden Pankreatitis (ANP) werden hohe Kininmengen aus Kininogen freigesetzt. In 5 Hausschweine wurde Bradykinin (BK) (4–16 μg/kg x h) intravenös infundiert. Nach 2 bzw. 4 h BK-Infusion war der PaO2 signifikant erniedrigt. Die Lungenbiopsien zeigten Hyperämie, perivasculäres und interstitielles Lungenödem. Elektronenmikroskopisch sah man stark geschwollene Endothelzellen mit verbreiterten Basalmembranen und zahlreichen Flüssigkeit transportierenden Vacuolen. Kinine sind als ein weiterer Mediator für den Pathomechanismus des interstitiellen Lungenödems im Verlauf der ANP anzusehen.
    Notes: Summary High quantities of kinins are released in acute necrotizing pancreatitis (ANP). Bradykinin (BK) was intravenously infused (4–16 μg/kg per h) in five healthy pigs. After 2 or 4 h of BK infusion, PaO2 was significantly reduced. Lung biopsies showed hyperemia, and perivascular and interstitial edema. Electron microscopy revealed an enlarged basement membrane and swollen endothelial cells with a lot of vesicles, representing a highly intensified fluid exchange. Kinins are another mediator for the development of interstitial lung edema in ANP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274698
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  • 2
    Electronic Resource
    Electronic Resource
    Strained Ketenes from α-Bromoacyl Phosphates. (Tricyclo[4.4.1.01,6]undeca-3,8-dien-11-ylidene)methanone and its Heptacyclic Dimer: a Dispirobridged Dipropellane (1,1″,4,4″,5,5″,8,8″-Octahydrodispiro[[4a, 8a]methanonaphthalene-9,1′-cyClobutane-3′,9″-[4a, 8a]methanonaphthalene]-2′, 4′-dione) (1988)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 71 (1988), S. 1930-1936 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dehalogenation of the mixed anhydride 6 of 11-bromotricyclo[4.4.1.01,6] undeca-3,8-diene-11-carboxylic acid (4) and of diethyl hydrogen phosphate with Zn-Ag couple in THF gave the dispiro-fused dipropellane 8(1,1″,4,4″,5,5″,8,8″-octahydrodispiro[[4a, 8a]methanonaphthalene-9,1′-cyclobutane-3′,9″-[4a, 8a]methanonaphthalene]-2′,4′-dione) in 58% yield. Unlike other dispiro[2.1.2.1]octane-4, 8-diones (see 2a-e), the new cyclodimer 8 is an O2-sensitive compound. The 11-bromobicyclo[4.4.1] undeca-1,3,5,7,9-pentaene-11-carboxylic acid (13) was prepared and converted into the acyl phosphate 14, which in turn was reduced with Zn-Ag couple in THF/MeOD to give the deuterated ester 16. Other cyclopropylidenemethanones could be generated and dimerized advantageously by the Zn-induced reduction of the mixed anhydride of the 1-bromocyclopropanecarboxylic acid and diethyl hydrogen phosphonate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19880710812
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  • 3
    Electronic Resource
    Electronic Resource
    Terpenes and Terpenoid Compounds, 14. Synthesis of Oxygenated Derivatives in the Tetramethyllimonene Series. New Odorants of the Wood-ambergris Type (1985)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1985 (1985), S. 396-402 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Terpene und terpenoide Verbindungen, 141).  -  Synthese oxygenierter Derivate in der Tetramethyllimonen-Reihe.  -  Neue Geruchsstoffe des Holz-Ambra-TypsEine einfache Darstellung von TM-α-Terpineol (4), cis-TM-β-terpineol (6c), trans-TM-β-Terpineol (6t), TM-Δ1,7,Δ8-Menthadien (7) und seinem spirocyclischen Epoxid (5) sowie von TM-Isokrypton (8) wird beschrieben (TM = Tetramethyl). Anders als die einfachen C10-Monoterpene zeigen einige der neuen tetramethylierten Derivate Holz-Ambra-Geruch.
    Notes: A practical preparation of TM-α-terpineol (4), cis-TM-β-terpineol (6c), trans-TM-β-terpineol (6t), TM-Δ1,7,Δ8-menthadiene (7), its spirocyclic epoxide (5), and TM-isocryptone (8) is described (TM = tetramethyl). Some of the new tetramethylated monoterpenes, unlike the simple C10-monoterpenes, have a woody-ambergis-like odour.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198519850215
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  • 4
    Electronic Resource
    Electronic Resource
    Terpene und terpenoide Verbindungen, 15. Darstellung von tetramethyliertem Perillaalkohol [3,3,5,5-Tetramethyl-4-(1-methylethenyl)-1-cyclohexen-1-methanol] und verwandten Monoterpenoiden (1985)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1985 (1985), S. 403-412 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Terpenes and Terpenoid Compounds, 15.  -  Preparation of Tetramethylated Perillyl Alcohol [3,3,5,5-Tetramethyl-4-(1-methylethenyl)-1-cyclohexene-1-methanol] and Related MonoterpenoidsLithium perchlorate-induced rearrangement of 1,3,3,5,5-pentamethyl-4-(1-methylethenyl)-7-oxabicyclo[4.1.0]heptane (2) in toluene furnishes the epimeric tetramethylated dihydrocarvones 4t, c and 2,2,4,4-tetramethyl-6-methylene-3-(1-methylethenyl)-trans-cyclohexanol (5) in varying ratio. In acetic acid and formic acid the allylic alcohol 5 rearranges smoothly into the corresponding esters 6a and 6b which have been saponified quantitatively to yield tetramethylperillyl alcohol 7. Oxidation of tetramethylperillaldehyde 8 with air affords tetramethylperillic acid 9 in 54% yield. The epoxidation products of 5, 6a, and 7 are described.
    Notes: Die Lithiumperchlorat-induzierte Umlagerung von 1,3,3,5,5-Pentamethyl-4-(1-methylethenyl)-7-oxabicyclo[4.1.0]heptan (2) in Toluol liefert die epimeren Tetramethyldihydrocarvone 4t, c sowie 2,2,4,4-Tetramethyl-6-methylen-3-(1-methylethenyl)-trans-cyclohexanol (5) in variablem Verhältnis. In Essigsäure und Ameisensäure lagert sich der Allylalkohol 5 glatt in die entsprechenden Ester 6a und 6b um, die mit Alkali quantitativ zum Tetramethylperillaalkohol 7 verseift werden. Oxidation von Tetramethylperillaaldehyd 8 mit Luftsauerstoff ergibt Tetramethylperillasäure 9 in 54% Ausbeute. Die Produkte der Epoxidierung von 5, 6a und 7 werden beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198519850216
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  • 5
    Electronic Resource
    Electronic Resource
    Terpene und terpenoide Verbindungen, 17. Darstellung oxygenierter Tetramethylmenthene und Tetramethylmenthadiene (1985)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1985 (1985), S. 756-764 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Terpenes and Terpenoid Compounds, 17. - Preparation of Oxygenated Tetramethylmenthenes and TetramethylmenthadienesThe hydroboration of rac-TM-limonene (1) (TM = tetramethyl) with 9-BBN is chemoselective and allows the functionalization of the isopropenyl side chain to give rac-TM-Δ1-p-Menthen-10-ol (4a, b), the corresponding aldehyde 5a, b, and the acid 6. Protonolysis of the product of hydroboration affords rac-TM-Δ1-p-menthene (7). Hydrochlorination of 1, epoxidation, and treatment with lithium diisopropylamide yields rac-TM-Δ1(7),8-p-menthadien-10-ol (9) which is rearranged by acid into rac-TM-Δ1,8-p-menthadien-10-ol (11).
    Notes: Die Hydroborierung von rac-TM-Limonen (1) (TM = Tetramethyl) mit 9-BBN ist chemoselektiv und erlaubt die gezielte Funktionalisierung der Isopropenylseitenkette zu rac-TM-Δ1-p-Menthen-10-ol (4a, b), dem entsprechenden Aldehyd 5a, b sowie der Säure 6. Durch Protonolyse des Hydroborierungsproduktes erhält man rac-TM-Δ1-p-Menthen (7). Hydrochlorierung von 1, Epoxidierung und Behandlung mit Lithiumdiisopropylamid liefert rac-TM-Δ1(7),8-p-Menthadien-10-ol (9), das durch Säure in rac-TM-Δ1,8-p-Menthadien-10-ol (11) umgelagert wird.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198519850411
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