ISSN:
1435-1463
Keywords:
Nicotinamide adenine dinucleotide
;
tyrosine hydroxylase
;
DOPA
;
Parkinson
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The coenzyme nicotinamide adenine dinucleotide (NADH) has been used in an open label trial as novel medication in 34 patients with Parkinson's disease, using an intravenous administration technique. In all patients a beneficial clinical effect was observed. 21 patients (61.7%) showed a very good (better than 30%) improvement of disability, 13 patients (38.3%) a moderate (up to 30%) improvement. Concomitant with the improvement of the disability the urine level of homovanillic acid (HVA) increased significantly in all patients (in some patients by more than a 100%). The daily “on phases” of the patients could be increased from 2 up to 9 hours in the individual patients by NADH administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02263483
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