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  • 1985-1989  (7)
  • Column liquid chromatography  (4)
  • Immunohistochemistry  (2)
  • Polycyclic aromatic hydrocarbons  (2)
  • 1'-deoxyabscisic acid
  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural and immunohistochemical studies on non-ciliated cells of the tracheal epithelium of normal, phenobarbital-treated, and 3-methylcholanthrene-treated mice (1985)
    Springer
    Cell & tissue research 240 (1985), S. 501-504 
    Details
    ISSN: 1432-0878
    Keywords: Non-ciliated tracheal cell ; Smooth endoplasmic reticulum ; Ultrastructure ; Cytochrome P-450 ; Immunohistochemistry ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Non-ciliated SER-rich cells of the tracheal epithelium of normal, phenobarbital-treated and 3-methylcholanthrene-treated mice were studied ultrastructurally and immunohistochemically. The apical portion of these cells protrudes into the tracheal lumen, especially in the mice treated with the two compounds, and the apical cytoplasm is filled with numerous tubular elements of SER. Besides, the non-ciliated cells of 3-methylcholanthrene-treated mice show a strong positive reaction to the antiserum against microsomal cytochrome P-450 of liver. These findings support the concept that the non-ciliated tracheal cell may be involved in the metabolism of endogeneous and exogeneous chemical compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222368
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructural and immunohistochemical studies on steroid-secreting cells of the testis and ovary of normal and 3-methylcholanthrene-treated mice (1986)
    Springer
    Cell & tissue research 245 (1986), S. 681-683 
    Details
    ISSN: 1432-0878
    Keywords: Smooth endoplasmic reticulum ; Cytochrome P-450 ; Testis ; Ovary ; Immunohistochemistry ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The testis and ovary of normal and 3-methylcholanthrene-treated mice were studied ultrastructurally and immunohistochemically in order to learn whether steroid-secreting cells of the gonads are involved in drug metabolism. The steroid-secreting cells, i.e., Leydig cells of the testis, and theca interna cells, interstitial gland cells, and corpus luteum cells of the ovary of 3-methylcholanthrene-treated mice, show a strong positive reaction to the antiserum against, hepatic microsomal cytochrome P-450, of liver which is the terminal oxidase of the drug-metabolizing enzyme complex. In addition, it was found that elements of smooth endoplasmic reticulum (SER) in drug-treated mice become well developed as compared with those in control animals. These findings indicate that the steroid secreting cells in testis as well as ovary are involved in the metabolism of both endogenous and exogenous chemical compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218572
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Study on retention behavior of peropyrene-type polycyclic aromatic hydroccrbons with various bonded stationary phases in reversed-phase liquid chromatography (1988)
    Springer
    Chromatographia 25 (1988), S. 483-486 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Reversed-phase diphenyl and naphtylethyl bonded phases ; Retention/molecular polarizability relationships ; Peropyrene aromatics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention behavior of 15 peropyrene-type polycyclic aromatic hydrocarbons was investigated on various bonded stationary phases in reversed-phase liquid chromatography. On diphenyl and naphthylethyl bonded phases, high correlations were obtained between the molecular polarizability of solutes and their retention. However, very low or no correlations were found on various octadecyl bonded phases. These facts are discussed by using the electrostatic interaction concept between the solutes and the stationary phase. We conclude that these observations are due to two reasons: the difference in the degree of planarity of polycyclic aromatic hydrocarbons and the high ability of planarity recognition of octadecyl bonded phases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02324817
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Compatibility and universality of the retention prediction system for polycyclic aromatic hydrocarbons in reversed-phase liquid chromatography (1986)
    Springer
    Chromatographia 21 (1986), S. 24-28 
    Details
    ISSN: 1612-1112
    Keywords: Column-liquid chromatography ; Retention prediction system ; Reversed-phase ; Compatibility ; Polycyclic aromatic hydrocarbons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary System-compatibility and universality of the retention prediction concept has been investigated for polycyclic aromatic hydrocarbons in reversed-phase liquid chromatography. The results clearly indicate that the retention prediction approach has a very high potential for optimization of separation conditions in almost all reversed-phase systems, and allows more precise and rapid analysis. This approach may be one of the best optimization techniques, because the system does not require any standard materials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02310590
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Liquid chromatographic determination of dimethadione and trimethadione in human serum on octadecyl treated microporous glass columns (1987)
    Springer
    Chromatographia 23 (1987), S. 325-327 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Packings of octadecylated microporous glass ; Dimethadione and trimethadione in serum ; Pancreatic stones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The liquid chromatographic determination of trimethadione (TMO) and its methabolite, dimethadione (DMO) were studied by high-performance liquid chromatography (HPLC) on octadecyl-modified microporous glasses, prepared with toluene solution containing octadecyl-dimethylchlorosilane, using two types of microporous glass with various mean pore diameters and/or specific surface areas. Using acetonitrile-water mixtures as eluents, TMO and DMO in human serum were separated on the glasses studied, but with different degrees of resolution. In this present study, we report the development of a rapid and selective HPLC method for the simultaneous analysis of TMO and DMO in human serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02316176
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The influence of the pore size of bonded phases containing phenyl groups on the retention of polycyclic aromatic hydrocarbons in reversedphase liquid chromatography (1985)
    Springer
    Chromatographia 20 (1985), S. 242-248 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Phenyl bonded phases ; Effect of pore size on retention ; Polycyclic aromatic hydrocarbons ; Silica supports
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Differences in bonded phase properties were studied for triphenyl, diphenyl, phenyl and benzyl phases prepared on a variety of silicas. A total of six silicas with pore diameters ranging from 100 to 200 Å were used in the synthesis. The effect of the pore diameter of the silicas on the retention of polycyclic aromatic hydrocarbons are discussed. Differences in retention were observed as a function of pore size, but not much difference was observed with substrates having pore sizes larger than about 170Å. The observed phenomena are explained by two steric exclusion mechanisms, one during the bonding reaction, and the other in the chromatographic analysis. Statistical calculations were performed using the descriptors showing molecular size and/or shape. The results indicated that the difference between bulky phases and less bulky phases was only observed in the degree of shape-recognition ability of the solute while no differences exist in the retention mechanisms on the different phases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02259696
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Retention behaviour in micro-HPLC on various types of glasses modified with phenyl groups (1986)
    Springer
    Chromatographia 21 (1986), S. 467-472 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Bonded stationary phases ; Phenyl-modified glasses ; Antiepileptic drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention and selectivity behaviour of some antiepileptic drugs were studied by micro high-performance liquid chromatography on nine types of phenyl-modified glasses, prepared with xylene solution containing phenyldimethylchlorosilane (P), diphenylmethylchlorosilane (D) or triphenylchlorosilane (T), using three types of glass with various mean pore diameters and/or specific surface areas. From elemental analysis data for carbon, the maximum number of accessible phenyl surface groups per 100Å2 of glass (mean pore diameter: 335Å, specific surface area: 69m2/g) in P, D and T gel was calculated to be 2.38, 1.58 and 0.76, respectively. Using various CH3CN−0.01 M KH2PO4 mixtures as eluents, the antiepileptic drugs were separated on all the glasses studied, but with different degrees of resolution. With an increase in the specific surface area, the k′ values of some antiepileptic drugs also increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02341272
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    Paper (German National Licenses)
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