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  • 1985-1989  (2)
  • 1-Sinapoylglucose:L-malate sinapoyltransferase (control)  (1)
  • Osteosarcoma  (1)
  • 61.70
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  • 1
    ISSN: 1432-2048
    Keywords: Amino acid synthesis (inhibition) ; Malate ; Nitrogen nutrition ; Phenylpropanoid metabolism ; Raphanus ; Seedling development ; 1-Sinapoylglucose:L-malate sinapoyltransferase (control)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The control of malate metabolism and stimulation of 1-sinapolyglucose: L-malate sinapoyltransferase (SMT) activity in radish (Raphanus sativus L. var. sativus) cotyledons has been studied. The light-induced and nitrate-dependent activity of SMT catalyzes the formation of O-sinapoly-L-malate via 1-O-sinapoyl-β-D-glucose. When dark-grown radish seedlings, cultivated in quartz sand with nutrient solution containing NO 3 - as the sole N source, were treated with light, SMT activity increased concomitantly with free malate in the cotyledons. This light effect was suppressed in seedlings grown in a culture medium which contained in addition to NO 3 - also NH 4 + . However, treatment with methionine sulfoximine neutralized this ammonium effect, resulting again in both rapid accumulation of malate and rapid increase in SMT activity. When seedlings grown on NO 3 - nitrogen were subsequently supplied with NH 4 + nitrogen, the accumulated level of L-malate rapidly dropped and the SMT increase ceased. The enzyme activity decreased later on, reaching the low activity level of plants which were grown permanently on NO 3 - /NH 4 + -nitrogen. An external supply (vacuum infiltration) of malate to excised cotyledons and intact seedings, grown on NO 3 - /NH 4 + -nitrogen medium, specifically promoted a dose-dependent increase in the activity of SMT. In summary these results provide evidence indicating that the SMT activity in cotyledons of Raphanus sativus might be related to the metabolism of malic acid.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 10 (1986), S. 245-251 
    ISSN: 1432-5195
    Keywords: Osteosarcoma ; Preoperative chemotherapy ; Intra-arterial infusion ; Limb Salvage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'amputation reste le traitement habituel des malades atteints d'ostéosarcome. Cependant, chez des sujets soigneusement choisis, l'éradication de la lésion primitive peut être obtenue par résection de l'os atteint. De 1963 à 1984 les auteurs ont observé 77 patients porteurs d'un ostéosarcome des membres. 46 d'entre eux ont été traités par intervention chirugicale et chimiothérapie pré et post-opératoire. Présentation des 11 malades de ce groupe qui ont bénéficié d'une résection avec conservation de leur membre.
    Notes: Summary Amputation remains the standard surgical treatment for patients with osteosarcoma. However, in carefully selected patients, eradication of the primary lesion can be achieved by en bloc resection of the affected bone. Between 1963 and 1984, 77 patients with osteosarcoma of the extremity were seen. Forty-six patients were managed with combined treatment which included preoperative chemotherapy, operation and postoperative adjuvant chemotherapy between 1968 and 1984. We report the 11 patients in this group who underwent limbsalvage procedures.
    Type of Medium: Electronic Resource
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