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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 217 (1974), S. 263-271 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine neue Möglichkeit, die Entstehung von Fibrinoidablagerungen in der menschlichen Placenta zu erklären, wird vorgestellt. Die intravenöse Applikation eines enzymatisch abgebauten menschlichen IgG-Präparates, (Fab′) 2G, an Schwangere führt zu einer quantitativ bestimmten Vermehrung der fibrinoid umgewandelten Endzotten im Vergleich zu Placenten nach normaler Schwangerschaft und nach EPH-Gestose. Immunhistologisch wird das Zottenepithel als Reaktionsort erkannt. Es wird vermutet, daß die fibrinoide Umwandlung in den Endzotten durch eine Schädigung des diaplacentaren Transportmechanismus zustande kommt.
    Notes: Summary A new possibility is shown to explain the deposits of fibrinoid material in the human placenta. The pepsin digested purified IgG-fragment (Fab′) 2G, given intravenously to pregnant women, causes a statistically significant increase of fibrinoid deposits in terminal villi, as compared with placentae from normal pregnancies and from EPH gestosis. As shown by the fluorescent antibody technique, reaction seems to take place in the villous epithelium. The deposition of fibrinoid might possibly be caused by disturbances resp. blockage of transport mechanisms across the placenta.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2048
    Keywords: Amino acid synthesis (inhibition) ; Malate ; Nitrogen nutrition ; Phenylpropanoid metabolism ; Raphanus ; Seedling development ; 1-Sinapoylglucose:L-malate sinapoyltransferase (control)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The control of malate metabolism and stimulation of 1-sinapolyglucose: L-malate sinapoyltransferase (SMT) activity in radish (Raphanus sativus L. var. sativus) cotyledons has been studied. The light-induced and nitrate-dependent activity of SMT catalyzes the formation of O-sinapoly-L-malate via 1-O-sinapoyl-β-D-glucose. When dark-grown radish seedlings, cultivated in quartz sand with nutrient solution containing NO 3 - as the sole N source, were treated with light, SMT activity increased concomitantly with free malate in the cotyledons. This light effect was suppressed in seedlings grown in a culture medium which contained in addition to NO 3 - also NH 4 + . However, treatment with methionine sulfoximine neutralized this ammonium effect, resulting again in both rapid accumulation of malate and rapid increase in SMT activity. When seedlings grown on NO 3 - nitrogen were subsequently supplied with NH 4 + nitrogen, the accumulated level of L-malate rapidly dropped and the SMT increase ceased. The enzyme activity decreased later on, reaching the low activity level of plants which were grown permanently on NO 3 - /NH 4 + -nitrogen. An external supply (vacuum infiltration) of malate to excised cotyledons and intact seedings, grown on NO 3 - /NH 4 + -nitrogen medium, specifically promoted a dose-dependent increase in the activity of SMT. In summary these results provide evidence indicating that the SMT activity in cotyledons of Raphanus sativus might be related to the metabolism of malic acid.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Schmerz 11 (1997), S. 180-184 
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Lumboischialgie ; Steroide ; Zytokinhemmung ; Akupunktur ; Naturheilmittel ; Key words Sciatic pain ; Steroids ; Cytokine inhibition ; Acupuncture ; Herbal medicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Introduction: Because of their frequency and consequences sciatica remains a demanding clinical entity with significant social and economical impact. There is a high demand on therapeutic modalities, using folk medicine methods in the treatment of orthopaedic diseases. No data is available on the usefullness of methods like natural herbs in combination with acupuncture. Aim of our study was to present data on the effect of acupuncture and cytokineinhibiting natural herbs in sciatic pain. We compared these results with nerve root infiltration by local anaesthetics and corticosteroids in our orthopaedic outpatient clinic. Materials and Results: 278 patients with chronic pain for at least 3 months were observed. All three therapeutical modalities showed improvement of pain scores. Best results were gained with steroid injection (n=26; 66% pain reduction), acupuncture in combination with herbs improved the pain in average of 62% (n=230), whereas injection with local anaesthetic had a pain reduction of 48% (n=22). Sole Mepivacain-HCl treatment had significant less pain reduction compared to the other treatment modalities. Conclusion: According to our results acupuncture in combination with herbs and steroid nerve blocks appear to be an effective and thus recommendable conservative therapy in cases of sciatic pain. Taking into account that patients increasingly prefer ethnomedical modalities of treatment our study gains importance for practising orthopaedists.
    Notes: Zusammenfassung Einleitung: Wirbelsäulenbedingte Kreuzbeinschmerzen (Lumboischialgien) haben aufgrund ihrer Häufigkeit und Konsequenzen eine außerordentlich große Bedeutung sowohl im medizinischen als auch im sozialen Bereich. Wir berichten über unsere Erfahrungen in der Behandlung dieses Beschwerdebilds mit Akupunktur in Kombination mit in vitro zytokinhemmenden Naturstoffen. Diese Ergebnisse wurden mit einer Wurzelblockadenbehandlung mit Lokalanästhetika (Mepivacain-HCl) oder Glukokortikoiden (Triamcinolonazetonid) verglichen. Material und Ergebnisse: Es wurden insgesamt 278 Patienten (Schmerzen von mindestens 3monatiger Dauer) ausgewertet. Alle ausgewerteten Modalitäten zeigten im Mittel eine Schmerzreduktion 5 Wochen nach Behandlungsbeginn (0%=kein Schmerz, 100%=Schmerz unmittelbar vor der Behandlung). Die höchste Reduktion (n=26; 66% Schmerzreduktion) konnte bei einer Wurzelblockadenbehandlung von Triamcinolonazetonid 20 mg mit Sandicain 1% beobachtet werden. Die bei einer kombinierten Behandlung von Akupunktur mit Naturstoffen beobachtete Schmerzreduktion betrug im Mittel 62% (n=230), Wurzelblockaden ausschließlich mit Mepivacain-HCl 1% zeigten eine Reduktion von 48% (n=22). Schlußfolgerung: Die Ergebnisse zeigen, daß sowohl Wurzelblockaden mit Triamcinolonazetonid als auch Akupunktur in Kombination mit Naturstoffen in Fällen chronischer Lumboischialgien eine effektive konservative Therapie darstellen. Vor dem Hintergrund, daß Patienten zunehmend ethnomedizinische Verfahren favorisieren, sind die Resultate unserer Untersuchung für den Schmerztherapeuten als interessant zu werten.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Astrophysics and space science 230 (1995), S. 383-392 
    ISSN: 1572-946X
    Keywords: Cosmic rays ; Modulation models ; Calculated spectra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A description of the cosmic ray state of the heliosphere during solar minimum conditions is given. This solar minimum state is defined as the shape of particle spectra observed throughout the heliosphere during the 1977 and 1987 solar minima, mainly as observed by thePioneer andVoyager spacecraft. Model solutions of the Parker transport equation are compared with these observations, and the parameters needed for these model fits are discussed. This work forms part of an ongoing investigation at the Space Research Unit to understand the modulation of cosmic rays through numerical solutions of the transport equation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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