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  • 1
    Electronic Resource
    Electronic Resource
    Gene diagnosis in X-linked ichthyosis (1989)
    Springer
    Archives of dermatological research 280 (1989), S. 457-461 
    Details
    ISSN: 1432-069X
    Keywords: X-linked ichthyosis ; Steroid sulfatase deficiency ; DNA diagnosis ; Carrier detection ; Gene deletion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three families segregating for X-linked ichthyosis (XLI) were analysed using the full-length STS cDNA probe and an anonymous polymorphic DNA sequence closely linked to the STS gene. In patients from two of the families, submicroscopic chromosomal deletions could be detected using both the STS and the GMGX9 (DXS237 locus) probes. Patients in the third family showed the same hybridization pattern as healthy males following molecular hybridization with either of the probes. The results of DNA analysis (indirect geno-type diagnosis) agree well with those based on the arylsulfatase C/β-gal determination and prove the reliability of the biochemical test. Both methods are discussed for carrier detection, prenatal diagnosis, and genetic conselling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427656
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Delayed phototoxic effects of 8-methoxypsoralen, khellin, and sphondin inAedes aegypti (1986)
    Springer
    Journal of chemical ecology 12 (1986), S. 899-914 
    Details
    ISSN: 1573-1561
    Keywords: Phototoxicity ; 8-methoxypsoralen ; sphondin ; khellin ; Aedes aegypti ; Diptera ; Culicidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract At concentrations up to 6.7 ppm, 8-methoxypsoralen, sphondin, and khellin are not toxic to first-instar larvae of the mosquitoAedes aegypti. The irradiation of sensitized larvae with long-wavelength ultraviolet light did not always produce any immediate toxicity enhancement, but delayed effects were clearly visible. These were observed over the development of the organisms from first-instar larvae to adults. No adverse effects were noted when larvae were irradiated in the absence of sensitizers, or when they were placed in solutions of sensitizers which had been previously irradiated with the same light sources. 8-Methoxypsoralen was slightly more phototoxic than its isomer sphondin. Khellin, recently reported to undergo photoinduced cyclization with DNA components, showed minimal phototoxicity in the concentration range used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01020260
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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