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  • 1985-1989  (2)
  • Angioplastic procedures  (1)
  • Bicarbonate transport  (1)
  • 1
    ISSN: 1432-2013
    Keywords: Rabbit gallbladder ; Cl−/HCO 3 − , Na+/H+ uncoupling ; Bicarbonate transport ; Intracellular Na+ activity ; SITS ; Amiloride ; SCN
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The transapical Cl− influx and transepithelial Na+ transport were measured in rabbit gallbladder. Only 11.7% of the transported Na+ was found to be accompanied by HCO 3 − . 10−4 M SITS eliminated the HCO 3 − dependent fraction of Cl− influx (50%) but did not significantly alter intracellular Na+ activity and Na+ transport. Exposure to HCO3-free salines or to 10−4 M acetazolamide about halved Cl− influx and Na+ transport. 25 mM SCN− reduced Cl− influx to zero, decreased intracellular Na+ activity, but only halved Na+ transport which under these conditions was abolished only in the absence of HCO 3 − . Exposure to a Cl−-free saline produced effects similar to those caused by SCN−. These resuits suggest that when Cl−/HCO 3 − exchange is inhibited at the apical membrane, Na+/H+ exchange and transepithelial Na+ transfer are unmodified if HCO 3 − is available for transport. The permanent uncoupling of the exchangers and the elevated transepithelial transport of Na+ are not due to an increased activity of the parallel Na+−Cl− cotransport but to a redirection of HCO 3 − flux toward the basolateral side.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 371 (1987), S. 85-101 
    ISSN: 1435-2451
    Keywords: Bronchial carcinoma ; Bronchoplastic procedures ; Angioplastic procedures ; Surgical techniques ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bronchoplastische und angioplastische Operationen beim Bronchialcarcinom stellen eine parenchymsparende Alternative zur Pneumonektomie dar. Diese Eingriffe sind vor allem bei Patienten mit einer eingeschränkten Lungenfunktion und zentralem Sitz des Neoplasmas indiziert. In einer retrospektiven Studie wurden insgesamt 248 broncho- und angioplastische Operationen aus den Jahren 1973–1983 ausgewertet. Stichtag der Überlebenszeitanalysen bildete der 1. Januar 1986. Die Mindestbeobachtungsdauer des Spätschicksals auch der erst 1983 operierten Patienten beträgt daher zwei Jahre. Für alle Patienten (n = 248) ergab sich eine 5-Jahres-Überlebensrate von 22% bei einer 30-Tage-Letalität von 13%. Die 5-Jahres-Überlebenszeit aller radikal operierten Bronchusmanschetten (Stadium I und II der TNM-Klassifikation,n = 44) beträgt 42% bei einer 30-Tage-Letalität von 7%. Bei allen bronchoplastischen Operationen in den Stadien I und II (n = 88) findet sich eine 5-Jahres-Überlebenszeit von 38% bei einer 30-Tage-Letalität von 14%. Verbessertes Nahtmaterial und Operationstechniken haben im Verlauf des Untersuchungszeitraums zu einer Senkung der Operationsletalität von 23% auf 8% geführt. Innerhalb der ersten 30 postoperativen Tage verursachten folgende Komplikationen einen letalen Ausgang: Hämoptoe (n = 5), Anastomoseninsuffizienz (n = 3), Rechtsherzversagen (n = 5), Lungenembolie (n = 4) und Sepsis (n = 1).
    Notes: Summary The various forms of bronchoplastic and angioplastic procedures are the best means of avoiding pneumonectomy. Essential indications are limited respiratory reserve and central site of a malignancy. In a retrospective study 248 broncho- and angioplastic operations carried out in the years 1973 to 1983 were analyzed. Reference date for the analysis of survival was January 1986. In consequence the minimum period of follow-up was two years. For all patients (n = 248) the 5-year-survival was 22% with a 30-day-lethality of 13%. The 5-year-survival of all bronchial sleeve resections operated radically (stage I and II of the TNM-classification) (n = 44) was 42% with a 30-day-lethality of 7%. The 5-year-survival of all bronchoplastic operations of stage I and II (n = 88) was 38% with a 30-day-lethality of 14%. Improved suture material and surgical techniques caused a reduction of operative lethality from 23% to 8% during the described period. In the first thirty postoperative days the following complications caused death: Hemoptysis (n = 5), insufficiency of the anastomosis (n = 3), right heart failure (n = 5), pulmonary embolism (n = 4) and sepsis (n = 1).
    Type of Medium: Electronic Resource
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