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  • 1985-1989  (2)
  • Anti-reserpine action  (1)
  • Thiol proteinase inhibitor  (1)
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Years
  • 1985-1989  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The identification of inhibitors in bromelin one-stage irregular antibody screening techniques (1987)
    Springer
    Annals of hematology 54 (1987), S. 51-55 
    Details
    ISSN: 1432-0584
    Keywords: Bromelin ; Antibody screening ; α2-Macroglobulin ; Thiol proteinase inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human sera contain bromelin inhibitors in irregular antibody screening techniques. In order to identify and purify these inhibitors, pooled human sera were precipitated with ammonium sulfate, followed by DEAE-cellulose and Sephadex G-150 column chromatography. Proteinase activity and inhibitory activity to bromelin were observed in two protein fractions, these were identified as α2-macroglobulin and the S-2 thiol proteinase inhibitor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326028
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Antagonizing effects of YM-14673, a new TRH derivative, on behavioral and electroencephalographic changes in reserpinized animals (1988)
    Springer
    Psychopharmacology 95 (1988), S. 162-166 
    Details
    ISSN: 1432-2072
    Keywords: YM-14673 ; TRH ; Anti-reserpine action ; PGO wave
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of YM-14673 (Nα-[{(S)-4-oxo-2-azetidinyl}-carbonyl]-l-histidyl-l-prolinamide dihydrate), a new TRH derivative, on reserpine-induced behavioural and electroencephalographic changes were observed in comparison with those of TRH. YM-14673 antagonized reserpine-induced hypothermia and decrease in convulsion threshold in mice. The number of PGO waves recorded from the lateral geniculate body was decreased by administration of YM-14673 in reserpinized cats. The anti-reserpine activity of intravenous YM-14673 was about 8–20 times more potent than that of TRH. In inhibiting reserpine-induced hypothermia, the oral ED2°C relative to IV ED2°C as an indirect indication of absorption rate of the drugs was 15 for both YM-14673 and TRH. These results suggest that YM-14673 possesses more potent facilitatory effects on the central monoamine systems than TRH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174502
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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