ISSN:
1432-1041
Keywords:
famotidine
;
H2-receptor antagonist
;
renal insufficiency
;
old age pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetics of the H2-receptor antagonist famotidine, after oral administration of a 20 mg tablet, has been studied in 10 elderly patients with normal renal function (CLCR≧59 ml·min−1, Mean=80 ml·min−1), 5 elderly patients with renal insufficiency (CLCR≦38 ml·min−1, Mean=15 ml·min−1), and 6 healthy young volunteers. Elimination half-life in the elderly patients with renal insufficiency was significantly prolonged compared to the elderly patients with normal renal function and the young volunteers. The correlation coefficient between creatinine clearance and the elimination rate constant of famotidine was 0.672. Mean urinary recovery of unchanged drug up to 24 h in the young volunteers was 44%. The mean renal clearance of famotidine in the young volunteers (270 ml·min−1) was substantially greater than the creatinine clearance, 128 ml·min−1, which suggests the possibility of tubular secretion of famotidine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558079
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