ISSN:
1432-2013
Keywords:
Human sweat duct
;
Cl− conductance
;
Cl− channel blockers
;
Cystic fibrosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To characterize the chloride conductance of human sweat duct the effect of various analogues of diphenylamine-2-carboxylate was investigated on the transepithelial potential difference (PDT) and resistance (R T ) of isolated microperfused sweat ducts. Although the most powerful analogues which block Cl− channels in various secretory and absorptive epithelia were ineffective, a number of analogues (in particular Cl substituted ones) were found which at high concentrations significantly and reversibly increased PDT andR T . The data suggest that the main chloride conductance pathway of sweat duct epithelium resides in the cell membranes rather than in the tight junctions. In addition the different blocking spectra of the chloride conductances of sweat duct and tracheal epithelium (Welsh MJ, Science 232:1648, 1986) suggest that the combined impairment of both conductances in cystic fibrosis does not result from a molecular defect in the Cl− channels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00585077
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