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  • 1985-1989  (2)
  • DNA sequence  (1)
  • focal ERG  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Evolution of keratin genes: Different protein domains evolve by different pathways (1987)
    Springer
    Journal of molecular evolution 24 (1987), S. 319-329 
    Details
    ISSN: 1432-1432
    Keywords: Intermediate filaments ; Gene families ; DNA sequence ; Tandem duplication ; Protein domains ; Glycine-rich regions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Intermediate filaments are composed of a family of proteins that evolved from a common ancestor. The proteins consist of three domains: a central, alpha-helical domain similar in all intermediate filaments, bracketed by two domains that are variable in length and structure. Within the intermediate-filament family, several subfamilies have been recognized by immunologic and nucleic acid hybridization techniques. In this paper we present the sequence of the genomic DNA coding for a 65-kilodalton human keratin and compare it with the sequences of other intermediate-filament proteins. While the central, alpha-helical domains of these proteins show homologies that indicate a common ancestor, the sequences of the variable terminal domains indicate that the variable domains evolved through a series of tandem duplications and possibly by gene-conversion mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02134130
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cone function in congenital nyctalopia (1987)
    Springer
    Documenta ophthalmologica 65 (1987), S. 307-318 
    Details
    ISSN: 1573-2622
    Keywords: focal ERG ; nyctalopia ; oscillatory potentials ; rod-cone interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with congenital stationary night blindness (CSNB) (Schubert-Bornschein type) transmitted as an autosomal recessive trait was studied with several tests of electrical function as well as a variety of psychophysical procedures. Comparison of the patient's present findings with those obtained 23 years earlier showed that while rod thresholds have remained the same, cone sensitivity has decreased. Subjective flicker thresholds obtained following a bleach were unchanged during the course of dark adaptation. The absence of rod-cone interaction, together with an absent scotopic b-wave, implies that the defect is in the mid-retinal layers. Further, the absence of oscillatory potentials in the photopic electroretinogram (ERG) suggests that the interplexiform cell may be implicated in some manner. The focal ERG of the CSNB patient showed normal amplitude and normal phase delays, supporting the idea that the focal ERG samples primarily cone photoreceptor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00149937
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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