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  • 1
    Digitale Medien
    Digitale Medien
    Biochemical and immunological analysis of a basic protein from newborn rat epidermis (1977)
    s.l. : American Chemical Society
    Biochemistry 16 (1977), S. 4856-4862 
    Details
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/bi00641a017
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  • 2
    Digitale Medien
    Digitale Medien
    Macromolecular metabolism in hyperplastic epidermal disease—a radio-autographic study (1974)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 91 (1974), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Radio-autographic techniques have been applied to the study of three hyperplastic human epidermal diseases; psoriasis, seborrhoeic keratoses and Bowen's disease. In each, a different alteration of nucleic acid and protein synthesis has been found when the abnormal tissue is compared to clinically normal contiguous skin. Psoriasis was characterized by stimulation of DNA, RNA and protein synthesis, while in mature seborrhoeic keratoses DNA synthesis was decreased at the same time as RNA and protein synthesis were increased. In Bowen's disease DNA and protein synthesis were enhanced, but the number of cells involved in RNA synthesis was decreased.Similar methods have been applied to psoriatic epidermis during treatment with vitamin A acid ointment. The medication resulted in inhibiton of DNA synthesis at a time when RNA and protein synthesis were enhanced.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1974.tb12942.x
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  • 3
    Digitale Medien
    Digitale Medien
    Chromosomal Localization of Mouse Hair Keratin Genes (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 642 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb24378.x
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  • 4
    Digitale Medien
    Digitale Medien
    III. THE RIBONUCLEASES OF HUMAN EPIDERMIS (1977)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 97 (1977), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Sodium acetate and sulphuric acid extracts of human epidermis can each be separated by chromatographic techniques into three or more fractions with ribonuclease activity. Eight of these fractions were compared with respect to molecular weight, pH activity profile, polyribonucleotide hydrolysis, and activity in the presence of low levels of spermidine. Sodium acetate and sulphuric acid extracts were also prepared from callus and from psoriatic lesions and compared with extracts from normal epidermis for their response to exogenous spermidine.All eight human epidermal ribonuclease fractions studied had an apparent molecular weight of 15,000 daltons. Seven of the ribonuclease fractions were optimally active at alkaline pHs (pH 7.3–7.6 in sodium phosphate and pH 81.in Tris-HCl) while the eighth ribonuclease was most active at pH 5.6 in a citrate-phosphate buffer. All enzymes hydrolyzed polycytidylic acid and five also hydrolyzed polyuridylic add. None hydrolyzed polyadenylic acid. Seven of the eight ribonucleases studied exhibited greater activity in the presence of added spermidine. The extracts from psoriatic scales showed markedly elevated ribonuclease levels which could not be raised further by the addition of spermidine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1977.tb14242.x
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  • 5
    Digitale Medien
    Digitale Medien
    Evolution of keratin genes: Different protein domains evolve by different pathways (1987)
    Springer
    Journal of molecular evolution 24 (1987), S. 319-329 
    Details
    ISSN: 1432-1432
    Schlagwort(e): Intermediate filaments ; Gene families ; DNA sequence ; Tandem duplication ; Protein domains ; Glycine-rich regions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Intermediate filaments are composed of a family of proteins that evolved from a common ancestor. The proteins consist of three domains: a central, alpha-helical domain similar in all intermediate filaments, bracketed by two domains that are variable in length and structure. Within the intermediate-filament family, several subfamilies have been recognized by immunologic and nucleic acid hybridization techniques. In this paper we present the sequence of the genomic DNA coding for a 65-kilodalton human keratin and compare it with the sequences of other intermediate-filament proteins. While the central, alpha-helical domains of these proteins show homologies that indicate a common ancestor, the sequences of the variable terminal domains indicate that the variable domains evolved through a series of tandem duplications and possibly by gene-conversion mechanisms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02134130
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  • 6
    Digitale Medien
    Digitale Medien
    A simple method for accurately locating and cutting strips from the isoelectric focusing gel during two-dimensional electrophoresis using the phastsystem (1989)
    Weinheim : Wiley-Blackwell
    Electrophoresis 10 (1989), S. 223-224 
    Details
    ISSN: 0173-0835
    Schlagwort(e): Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: A rapid and simple method has been developed for precisely locating and cutting 1-3 mm strips from the isoelectric focusing gel during two-dimensional electrophoresis using the PhastSystem. The protocol utilizes an easily constructed styrofoam template with marks to guide accurate cutting of the strips from the sample lanes. This system greatly enhances the reproducibility and quality of the two-dimensional patterns obtained.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/elps.1150100313
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  • 7
    Digitale Medien
    Digitale Medien
    Ultrasensitive polychromatic silver staining of sodium dodecyl sulfate-polyacrylamide gels with the Gelcode system using the PhastSystem Development Unit (1989)
    Weinheim : Wiley-Blackwell
    Electrophoresis 10 (1989), S. 535-536 
    Details
    ISSN: 0173-0835
    Schlagwort(e): Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: The Gelcode color-based silver staining system, an improved formulation based on the original publication by Sammons et al. (Electrophoresis 1981, 2, 141-147) has been adapted to automated rapid staining in the PhastSystem Development Unit. The use of elevated temperatures in the fixation, washing, staining, and stabilization steps of the protocol reduces the total time of the process from 18 h to 1 h. The limit of detection, which is at least tenfold more sensitive than the silver staining protocol recommended for the PhastSystem, corresponds to 0.05-0.1 ng of protein per band. The method is applicable to both one- and two-dimensional polyacrylamide gels.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/elps.1150100717
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