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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Documenta ophthalmologica 67 (1987), S. 315-326 
    ISSN: 1573-2622
    Keywords: color vision ; cone function ; electrophysiology ; fundus flavimaculatus ; retinal degeneration ; rod function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate functional differences between fundus flavimaculatus and ophthalmoscopically similar diseases, we performed testing of spectral sensitivity, transient tritanopia, visual fields, fluorescein angiography, color vision, electrophysiological parameters, dark adaptation, cone flicker threshold during dark adaptation, and a thorough clinical investigation in five patients. Four had characteristic fundus flavimaculatus, while one patient turned out to have an atypical form. All five patients showed similar results in clinical investigations, electrophysiological data, and visual field tests. However psychophysical tests showed a number of differences in the single atypical patient. Although his ophthalmoscopic picture was not entirely typical of fundus flavimaculatus, only his psychophysical data could identify the patient as functionally distinct from the other four.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Documenta ophthalmologica 65 (1987), S. 287-296 
    ISSN: 1573-2622
    Keywords: dopamine antagonists ; ERG-b-wave ; fluphenazine ; optic nerve response ; PIII ; perfused eye ; rods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of various concentrations of the dopamine antagonist fluphenazine on ocular field potentials, recorded under scotopic conditions from isolated, arterially perfused cat eyes, was studied. Responses from outer (isolated Pill-component of the electroretinogram, ERG), middle (b-wave), and inner (optic nerve response, ONR) retinal layers were separated. Neither the fast or slow Pill-amplitude nor the temporal characteristics of the response were influenced by any of the drug concentrations tested. In contrast, fluphenazine reversibly increased the rod b-wave amplitude over a large range of concentrations. Only very high drug concentrations led to an irreversible loss of the b-wave. In the ONR the initial transient on-response increased during drug injection, whereas the sustained on-response and off-response decreased. In summary, the dopamine antagonist fluphenazine affects mainly the signal processing of the rod pathway in the inner retinal layers, while responses from outer retinal layers are not influenced. On- and off-responses of the ONR are affected differently.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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