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Malignant sacrococcygeal teratoma: improved survival with chemotherapy (1989)

Shanbhogue, L. K. R. ; Gough, D. C. S. ; Jones, P. M.

Springer

Pediatric surgery international 4 (1989), S. 202-204

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ISSN: 1437-9813

Keywords: Malignant sacrococcygeal teratoma ; Excision ; Chemotherapy

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Between 1954 and 1985, 15 cases of malignant sacrococcygeal teratoma were treated in our institution. Median age at presentation was 20 months (range 9–46 months); there were 14 females and 1 male. Six cases presenting prior to 1970 were treated without chemotherapy with a median survival of 2 months (range 1–7 months). Five patients treated from 1971 to 1979 had tumour excision plus vincristine, actinomycin D, and cyclophosphamide (VAC). Three received radiotherapy in addition and median survival was 11 months (range 0–31 months). Four patients presenting since 1980 had chemotherapy alone after tumour excision. 1 receiving VAC and adriamycin and the remaining patients cisplatinum, bleomycin, and VP16. All these are alive and disease free (median follow-up 27 months; range 15–96 months). It is concluded that initial surgery aimed at complete excision followed by aggressive chemotherapy gives good results.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00181986

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Reaktionen von (η2-Ethen)bis(triphenylphosphan)-platin(0) mit dimerem Hexafluorthioaceton Darstellung und Struktur von Platinacyclopentan- und -cyclopropanderivaten (1986)

Jones, P. G. ; Roesky, H. W. ; Gries, Th. ; [et al.]

Weinheim : Wiley-Blackwell

Zeitschrift für anorganische Chemie 542 (1986), S. 46-52

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ISSN: 0044-2313

Keywords: Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Reactions of (η2-Ethene)bis(triphenylphosphane)platinum(0) with Dimeric Hexafluorothioacetone. Preparation and Structure of Platina Cyclopentane and Cyclopropane DerivativesThe five-membered (CS)2Pt ring 1 was obtained by the reaction of 2, 2, 4, 4-tetrakis(trifluoromethyl)-1,3-dithietane and (η2-ethene)bis(triphenylphosphane)platinum(0) at low temperatures. 1 is converted at its melting point to the three-membered CSPt ring derivative 2, with elimination of one molecule of hexafluorothioacetone. 2 is also formed directly when the reaction is conducted at temperatures above +30°C. 2 was characterized by an X-ray Structural analysis.

Notes: Der fünfgliedrige (CS)2Pt-Cyclus 1 kann aus 2, 2, 4, 4-Tetrakis(trifluormethyl)-1,3-dithietan und (η2-Ethen)bis(triphenylphosphan)-platin(0) bei tiefer Temperatur erhalten werden. 1 wandelt sich an seinem Schmelzpunkt unter Abspaltung eines Moleküls Hexafluorthioaceton in den um zwei Ringglieder reduzierten CSPt-Ring 2 um, der auch auf direktem Wege durch Umsetzen des Dithietans bei Temperaturen oberhalb von +30° zugänglich ist. 2 konnte erstmals durch eine Kristallstrukturbestimmung charakterisiert werden.

Additional Material: 1 Ill.