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  • 1
    Electronic Resource
    Electronic Resource
    Effect of lipophilic cations on thiamine transport system in isolated rat hepatocytes (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 1022-1023 
    Details
    ISSN: 1420-9071
    Keywords: Thiamine uptake ; rat hepatocyte ; lipophilic cations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of lipophilic cations such as triphenylmethylphosphonium, tetraphenylphosphonium and tetraphenylarsonium in addition to dibenzyldimethylammonium on thiamine transport in isolated rat hepatocytes was studied. Lipophilic cations at the concentration 10 μM almost completely inhibited thiamine uptake. Kinetic studies showed that these compounds were competitive inhibitors with a very high affinity. These results suggest that lipophilic cations in addition to quaternary ammonium compounds also share a common binding site for thiamine in isolated rat hepatocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940715
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