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Digitale Medien

Effect of lipophilic cations on thiamine transport system in isolated rat hepatocytes (1986)

Yoshioka, K. ; Nishimura, H.

Springer

Cellular and molecular life sciences 42 (1986), S. 1022-1023

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Details

ISSN: 1420-9071

Schlagwort(e): Thiamine uptake ; rat hepatocyte ; lipophilic cations

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The effect of lipophilic cations such as triphenylmethylphosphonium, tetraphenylphosphonium and tetraphenylarsonium in addition to dibenzyldimethylammonium on thiamine transport in isolated rat hepatocytes was studied. Lipophilic cations at the concentration 10 μM almost completely inhibited thiamine uptake. Kinetic studies showed that these compounds were competitive inhibitors with a very high affinity. These results suggest that lipophilic cations in addition to quaternary ammonium compounds also share a common binding site for thiamine in isolated rat hepatocytes.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01940715

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