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  • 1985-1989  (2)
  • 1
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Fine needle aspiration (FNA) cytology is a valuable aid to diagnosis and tumour staging in patients with non-Hodgkin's lymphoma. These tumours are often multicentric and involve sites such as the liver or the spleen which are not easily accessible to surgical biopsy. Particularly with splenic involvement, there is a diagnostic problem of morphologically distinguishing the lymphoma cells in an admixture of normal lymphocytes. Since most lymphomas in adults are of B-cell origin, we studied the diagnostic value of adding a surface immunoglobulin (sIg) light chain analysis to the cytological evaluation of FNAs. B-clonal excess was determined by flow cytometric analysis of the sIg light chain distribution and a monoclonal finding was considered diagnostic of lymphoma. In primary diagnostic procedures the light chain analysis established a diagnosis of lymphoma in 5/14 (36%) aspirates from patients with poorly differentiated tumours. Fine needle aspirates performed as part of staging procedures were morphologically normal or inconclusive in 19 cases; in seven of these (37%) lymphoma involvement was diagnosed by the light chain analysis. Diagnostic precision was enhanced by combining morphological and immunological evaluation of fine needle aspirates in patients with established or suspected non-Hodgkin's lymphoma.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-5195
    Keywords: Tumours ; Soft-tissue ; Preoperative diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé En l'espace de trois ans, en Suède méridonale, on a rassemblé 35 malades porteurs de sarcomes profonds des membres, sans métastases. Trente d'entre eux ont été adressées avant toute intervention. Pendant la même période 37 patients présentant des tumeurs bénignes profondément situées ont été adressés pour suspicion de malignité. Dans 59 de ces 67 cas, un diagnostic pré-opératoire, suffisant pour déterminer le type d'intervention à réaliser, a été obtenu grâce à l'examen clinique, à l'examen radiologique et à la cytologie par ponction biopsie, mais sans biopsie opératoire. La distinction entre tumeur bénigne et maligne s'est révélée exacte dans tous les cas sauf un. L'étendue de l'excision nécessaire pour délimiter correctement un sarcome des parties molles peut souvent être réduite si la biopsie pré-opératoire a été évitée, permettant la conservation de la fonction. Les auteurs concluent que le traitement des malades porteurs de sarcomes des parties molles est possible dans la grande majorité des cas sans qu'il faille recourir à la biopsie chirurgicale.
    Notes: Summary Over a period of 3 years in Southern Sweden 35 patients were seen with deep-seated limb sarcomas without metastases, 30 of whom were referred before any operation had been carried out. Thirty seven patients with deep-seated benign lesions were referred during the same period because of suspected malignancy. A preoperative diagnosis considered sufficient for a definitive operation was made from the clinical findings, aspiration cytology and radiographic examination, but without open biopsy, in 59 of these 67 cases. The differentiation between a benign and a malignant tumour was correct in all but one. The extent of excision necessary to achieve adequate margins for a soft-tissue sarcoma can often be reduced if open biopsy is avoided, with preservation of function. We conclude that treatment without open biopsy is possible in the great majority of patients with soft-tissue sarcoma.
    Type of Medium: Electronic Resource
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