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  • 1
    Electronic Resource
    Electronic Resource
    Nicotine and smoking: a perspective from animal studies (1987)
    Springer
    Psychopharmacology 92 (1987), S. 135-143 
    Details
    ISSN: 1432-2072
    Keywords: Nicotine ; Tobacco ; Smoking ; Reinforcement ; Abstinence ; Cessation ; Nicotinic receptors ; Man ; Animals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nicotine plays a key role in reinforcing tobacco smoking, and exerts several psychoneuropharmacological actions which may contribute to its reinforcing effects. Thus, nicotine can improve mood and alleviate withdrawal symptoms; it can also alter CNS arousal, reduce stress, suppress appetite, and improve performance on certain tasks. Behavioural studies in animals have tended to corroborate existing theories of smoking behaviour, and have started to suggest how and where nicotine may exert its central actions in man. Clinical evidence suggests that smoking cessation would be facilitated by the administration of a nicotinic antagonist having a selective action on central nicotinic cholinoceptors of the C6 (ganglionic) type. Pharmacological studies in animals indicate that such a drug is a reasonable prospect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177905
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Apparent absence of nicotine-induced conditioned place preference in rats (1987)
    Springer
    Psychopharmacology 92 (1987), S. 84-88 
    Details
    ISSN: 1432-2072
    Keywords: Conditioned place preference ; Reinforcement ; Nicotine ; d-Amphetamine ; Methylphenidate ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The conditioned place preference (CPP) paradigm was used in order to assess the reinforcing actions of nicotine in rats. Subjects were tested in “unbiased” two-compartment shuttle boxes, so-called because neither compartment was consistently preferred prior to drug conditioning. In the first experiment, subjects that were initially drug naive showed neither a preference nor an aversion to the compartment that had been paired on four occasions with injection of nicotine (0.2–0.8 mg/kg SC); a similar result occurred in another group given daily injections of nicotine in the home cage prior to the experiment. In a second experiment, nicotine (0.4, 0.8 mg/kg SC) again failed to produce a CPP, whereas marked CPPs were seen in parallel groups of rats tested with either d-amphetamine or methylphenidate. Although nicotine has been reported to produce conditioned place preference, the present results suggest that it is not a robust phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215484
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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