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  • 1
    Electronic Resource
    Electronic Resource
    Molecular cloning, identification and ranscriptional analysis of genes involved in acetate utilization in Neurospora crassa (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 2 (1988), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Four Neurospora crassa genomic clones have been selected as hybridizing much more strongly to labeled mRNA isolated from acetate-grown mycelium than to mRNA from sucrose-grown mycelium. Hybridization of restriction fragments with acetate-specific mRNA or cDNA has been used to delimit the transcribed region(s) of each clone. The transcription of all four clones is strongly induced by transfer of growing mycelium from sucrose to acetate as sole carbon source. In wild-type mycelium, mRNAs corresponding to the four clones reach maximum levels after four hours of induction. They accumulate more rapidly and reach higher levels in an acetate non-utilizing mutant, acu-7, which has been found to overproduce enzymes of the glyoxylate cycle and to have a partial block in the TCA cycle. Molecular transformation of a Neurosporaacu-5 mutant and of an Aspergillus nidulans acuE mutant by DNA of clone 2 and clone 1, respectively, strongly suggests that clone 2 codes for acetyl-coenzyme A synthetase and that clone 1 codes for malate synthase. The transcribed segments of clones 1 and 2each hybridize to corresponding clones from Aspergillusnidulans (R. A. Sandeman and M. J. Hynes, personal communication).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1988.tb00068.x
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  • 2
    Electronic Resource
    Electronic Resource
    The fall of Nikolai Vavilov (1985)
    [s.l.] : Nature Publishing Group
    Nature 316 (1985), S. 769-770 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THIS book, by a former Soviet writer now resident in the United States, traces the career, downfall and destruction of the most famous Soviet biologist of the inter-war period. N.I. Vavilov was the son of a wealthy self-made businessman and one of two brothers, the other a physicist, who both ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/316769a0
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  • 3
    Electronic Resource
    Electronic Resource
    Initiation of recombination (1989)
    [s.l.] : Nature Publishing Group
    Nature 338 (1989), S. 14-15 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RECOMBINATION within genes is generally by conversion - that is, by unilateral transfer of information from one allele to the other. It can be, and often is, accompanied by nearby crossing over, but it is most often the conversion rather than any correlated crossover that is responsible for the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/338014a0
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  • 4
    Electronic Resource
    Electronic Resource
    Out in the open (1989)
    [s.l.] : Nature Publishing Group
    Nature 338 (1989), S. 214-215 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE molecular cloning of genes and their transfer between different kinds of cells and organisms is now a standard analytical method, practised in almost every modern university biological department, and fill-ing more than half of the pages of the leading biological journals. Anxiety about its ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/338214b0
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  • 5
    Electronic Resource
    Electronic Resource
    DNA in flux (1989)
    [s.l.] : Nature Publishing Group
    Nature 342 (1989), S. 26-27 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] AT THE level of the DNA sequence, chromosome structure is in a state of constant flux, usually slow but sometimes surprisingly rapid. Many processes sub-versive of conventional genetics have evidently been going on for aeons in the natural world, and over the past several decades descriptions of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/342026a0
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  • 6
    Electronic Resource
    Electronic Resource
    Premeiotic disruption of duplicated and triplicated copies of the Neurospora crassa am (glutamate dehydrogenase) gene (1989)
    Springer
    Current genetics 15 (1989), S. 327-334 
    Details
    ISSN: 1432-0983
    Keywords: Neurospora crassa ; ectopic genes ; methylation ; RIP phenomenon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Premeiotic inactivation of duplicated sequences (the RIP phenomenon of Selker et al.) was studied by tetrad analysis using ectopic copies of am + (coding for NADP-specific glutamate dehydrogenase) and a missense allele am 3, coding for a distinctive form of the enzyme, at the normal locus. In duplication crosses either both gene copies were inactivated or neither. Two inactivated am 3 derivatives were shown to have undergone methylation and numerous base-pair changes, reflected in losses and gains of restriction sites, but without sequence rearrangement. Cutting at restriction sites within the disrupted sequences was incomplete but became almost complete following growth in the presence of 5-azacytidine. In a triplication cross in which one parent carried two unlinked ectopic gene copies together with am 3 at the normal locus, premeiotic inactivation, when it occurred, tended to affect two of the three copies in any one ascus, but there were a few asci in which all three were inactivated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00419912
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  • 7
    Electronic Resource
    Electronic Resource
    Genetics, from A to Z. A dictionary of genetics. By Robert C. King and William D. Stansfield. O.U.P., 1985 (3rd ed.). Pp. 480. £25 (1986)
    New York, NY : Wiley-Blackwell
    BioEssays 4 (1986), S. 91-91 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950040214
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