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Insect sting anaphylaxis in patients without detectable serum venom-specific IgE (1985)

CLAYTON, W. F. ; GEORGITIS, J. W. ; REISMAN, R. E.

Oxford, UK : Blackwell Publishing Ltd

Clinical & experimental allergy 15 (1985), S. 0

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ISSN: 1365-2222

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Following insect sting anaphylaxis, twenty-five patients of over 500 evaluated, did not have detectable serum venom-specific IgE. Twenty-two were evaluated within 1 year of the reaction, fifteen within 6 months. Anaphylaxis occurred in six patients after their first sting exposure. The clinical features of the sting reaction were typical of the reaction occurring in insect-allergic patients with serum venom-specific IgE. Eleven of the twenty-five patients had negative venom skin tests. These observations suggest that a non-IgE mechanism may be responsible for a minority of insect sting reactions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2222.1985.tb03000.x

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Methylprednisolone versus prednisolone pharmacokinetics in relation to dose in adults (1986)

Szefler, S. J. ; Ebling, W. F. ; Georgitis, J. W. ; [et al.]

Springer

European journal of clinical pharmacology 30 (1986), S. 323-329

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ISSN: 1432-1041

Keywords: methylprednisolone ; prednisolone ; pharmacokinetics ; healthy volunteers

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The disposition and plasma binding of methylprednisolone were examined in seven normal volunteers following the administration of 5, 20 and 40 mg of intravenous methylprednisolone sodium succinate. Methylprednisolone exhibits linear plasma protein binding averaging 77%. The mean plasma methylprednisolone clearance of 337 ml·h−1. kg−1 was independent of dose. The steroid appears to moderately distribute into tissue spaces with a mean volume of distribution of 1.41·kg−1. Methylprednisolone disposition parameters were compared with the non-transcortin bound parameters for prednisolone. The prednisolone plasma clearance based on the transcortin free-drug is similar to methylprednisolone total plasma clearance. However, the corrected volume of distribution of prednisolone is only one-half that of methylprednisolone. The disposition rate of these two steroids is thus similar, in spite of their metabolic control by different enzymatic pathways and major influence of saturable transcortin binding on prednisolone elimination.