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  • 1985-1989  (3)
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Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    The macrophages as an effector cell in Giardia lamblia infections (1987)
    Springer
    Medical microbiology and immunology 176 (1987), S. 83-88 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Direct and antibody-dependent, cell-mediated cytotoxic responses exhibited against Giardia lamblia trophozoites by peritoneal macrophages of infected animals were studied. On first exposure, the infection persisted for 30 days and peak cytotoxic responses were noticed on the 20th day post infection. In reinfected animals, peak response was on 10th day and these animals were capable of clearing the infection much faster compared with animals infected for the first time. Macrophages in Giardia infection, therefore, seem to play an important role in providing resistance to infected animals as evident from significant augmentation of their cytotoxic responses in the infected animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200679
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cytotoxic activity of monocytes againstToxoplasma gondii in acute, chronic and reactivated murine toxoplasmosis (1988)
    Springer
    Medical microbiology and immunology 177 (1988), S. 339-348 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The phagocytic activity and cytotoxicity of peripheral blood monocytes (against toxoplasma tachyzoites) was studied in acute, chronic and reactivated toxoplasma infected Swiss albino mice. During acute infection, a low phygocytic activity was observed on the 4th day post infection (dpi) (P〈0.01) and a low monocyte cytotoxicity was noticed after the 2nd dpi (P〈0.01) which further decreased till the 8th dpi. In contrast, both the parameters were significantly increased during chronic infection. Increase in monocytic cytotoxicity was manifested on the 3rd dpi (P〈0.001) whereas phagocytosis showed an increase on the 12th dpi (P〈0.05). The reactivated group showed no change in both the parameters when compared with the control immunosuppressed group (P〉0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02389906
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Immunological response in experimentally reactivated toxoplasmosis in mice (1989)
    Springer
    Medical microbiology and immunology 178 (1989), S. 269-278 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Both humoral and cell-mediated immune responses were studied in reactivated toxoplasma infection in mice. The infection was established by immunosuppressing chronically infected animals by thymectomy followed by irradiation. The reactivated infection was confirmed by reappearance of toxoplasma tachyzoites in peritoneal exudate. The animals survived until the 8th day post thymectomy. The percentage of splenic T lymphocytes was depressed after 4th day post thymectomy in both the uninfected thymectomised and infected immunosuppressed animals as compared to the intact uninfected controls and intact chronically infected animals. However, there was no significant change (P〉0.05) between the uninfected immunosuppressed control and infected immunosuppressed mice. When the infection progressed to more acute phase there was significant depression (P 〈 0.01) in the percentage of T lymphocytes in comparison to the uninfected thymectomised mice. However, there was no change in the percentage of B lymphocytes (P〉0.05). The function of lymphocytes as assessed by blast transformation was depressed in the presence of nonspecific mitogens, i. e. phytohemagglutinin and concanavalin A until the end of the study. The response to toxoplasma antigen was increased during early stages in the infected immunosuppressed mice (stimulation index = 4.15±0.1 and 4.5±0.15 on 4th and 6th day post thymectomy). On the 8th day post thymectomy, there was a sudden fall in the stimulation index (3.5±0.11). The antitoxoplasma antibodies as detected by indirect hemagglitinin and fluorescence analysis and enzyme-linked immunosorbent assay (ELISA) tests and toxoplasma-specific IgM antibodies as detected by ELISA test were present throughout the study period though at low levels. The significance of these findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191061
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    Paper (German National Licenses)
    Fulltext
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